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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SNX18

Summary for SNX18

Gene information	Gene symbol	SNX18
	Ensembl ID	ENSG00000178996
	Entrez ID	112574
	Gene name	sorting nexin 18
	Synonyms	SH3PX2\|SH3PXD3B\|SNAG1
	Gene type	protein_coding
	UniProtAcc	Q96RF0

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Dataset with differentially expressed gene: SNX18

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.32568	2.12e-05
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	pDCs	-0.566537	2.82e-03
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.491442	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.419687	2.82e-39

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Expression of SNX18 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SNX18

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SNX18

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SNX18	hsa-miR-190a-3p	87.3706	NM_001102575
SNX18	hsa-miR-4698	87.2601	NM_001102575
SNX18	hsa-miR-12136	86.4294	NM_001145427
SNX18	hsa-miR-500b-5p	86.1806	NM_001102575
SNX18	hsa-miR-362-5p	86.1806	NM_001102575
SNX18	hsa-miR-338-3p	85.7588	NM_001145427
SNX18	hsa-miR-5693	85.733	NM_001145427
SNX18	hsa-miR-6806-5p	85.5955	NM_001145427
SNX18	hsa-miR-6811-5p	85.1509	NM_052870
SNX18	hsa-miR-6511b-5p	85.1509	NM_052870
SNX18	hsa-miR-6071	84.8264	NM_001102575
SNX18	hsa-miR-5689	84.7635	NM_001102575
SNX18	hsa-miR-4679	84.5597	NM_001145427
SNX18	hsa-miR-6502-5p	83.9928	NM_001102575
SNX18	hsa-miR-1301-5p	83.9928	NM_001102575
SNX18	hsa-miR-6511b-3p	83.9542	NM_001145427
SNX18	hsa-miR-6511a-3p	83.9542	NM_001145427
SNX18	hsa-miR-3148	83.656	NM_001145427
SNX18	hsa-miR-3202	83.6084	NM_052870
SNX18	hsa-miR-5582-5p	83.6009	NM_001145427
SNX18	hsa-miR-6833-3p	83.4408	NM_001145427
SNX18	hsa-miR-513a-5p	83.3499	NM_052870
SNX18	hsa-miR-125a-5p	83.2097	NM_001145427
SNX18	hsa-miR-4319	83.2097	NM_001145427
SNX18	hsa-miR-128-3p	83.0087	NM_001145427
SNX18	hsa-miR-30a-3p	82.8512	NM_052870
SNX18	hsa-miR-30d-3p	82.8512	NM_052870
SNX18	hsa-miR-30e-3p	82.8512	NM_052870
SNX18	hsa-miR-10a-5p	82.7117	NM_001102575
SNX18	hsa-miR-10b-5p	82.7117	NM_001102575
SNX18	hsa-miR-548x-3p	81.8732	NM_001102575
SNX18	hsa-miR-548aj-3p	81.8732	NM_001102575
SNX18	hsa-miR-934	81.8391	NM_052870
SNX18	hsa-miR-5193	81.5251	NM_001145427
SNX18	hsa-miR-5002-5p	81.4614	NM_001145427
SNX18	hsa-miR-216a-3p	81.2541	NM_001145427
SNX18	hsa-miR-125b-5p	80.6902	NM_001145427
SNX18	hsa-miR-4793-3p	80.4366	NM_001145427
SNX18	hsa-miR-4499	80.2816	NM_052870
SNX18	hsa-miR-944	80.1274	NM_001102575
SNX18	hsa-miR-548n	80.0683	NM_001102575
SNX18	hsa-miR-4732-3p	80.0207	NM_001145427

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Motifs and transcription factors (TFs) regulating SNX18

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SNX18	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SNX18	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SNX18	transfac_pro__M04617	ZBTB7A (directAnnotation).
SNX18	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SNX18	transfac_pro__M07387	ZBTB7A (directAnnotation).
SNX18	transfac_pro__M00716	ZBTB14 (directAnnotation).
SNX18	transfac_pro__M04893	TAF1 (directAnnotation).
SNX18	metacluster_135.11	NR2C2 (directAnnotation).
SNX18	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SNX18	metacluster_7.13	ZFX (directAnnotation).
SNX18	cisbp__M00968	MTF2 (directAnnotation).
SNX18	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SNX18	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SNX18	metacluster_198.3	ZFP64 (directAnnotation).
SNX18	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SNX18	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SNX18	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SNX18	cisbp__M00788	ZFY (inferredBy_Orthology).
SNX18	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SNX18	hdpi__ZNF304	ZNF304 (directAnnotation).
SNX18	transfac_pro__M01199	TRIM28 (directAnnotation).
SNX18	metacluster_151.2	ZNF23 (directAnnotation).
SNX18	transfac_pro__M03806	ZBTB7C (directAnnotation).
SNX18	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SNX18	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
SNX18	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
SNX18	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
SNX18	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
SNX18	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
SNX18	transfac_pro__M01253	CNOT3 (directAnnotation).
SNX18	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
SNX18	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
SNX18	jaspar__MA0748.2	YY2 (directAnnotation).
SNX18	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SNX18	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
SNX18	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
SNX18	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
SNX18	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SNX18	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
SNX18	transfac_pro__M00938	E2F1 (directAnnotation).
SNX18	transfac_pro__M04817	ZBTB33 (directAnnotation).
SNX18	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
SNX18	transfac_pro__M12697	ZNF142 (directAnnotation).
SNX18	metacluster_175.1	ZNF283 (directAnnotation).
SNX18	tfdimers__MD00364	WT1 (directAnnotation).
SNX18	transfac_pro__M02786	PLAGL1 (inferredBy_Orthology).
SNX18	transfac_pro__M01973	PLAG1 (directAnnotation).
SNX18	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
SNX18	tfdimers__MD00483	ZBTB14 (directAnnotation).
SNX18	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."