Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMURF2

Summary for SMURF2

Gene information	Gene symbol	SMURF2
	Ensembl ID	ENSG00000108854
	Entrez ID	64750
	Gene name	SMAD specific E3 ubiquitin protein ligase 2
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9HAU4

Top

Dataset with differentially expressed gene: SMURF2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.617022	0.00e+00

Top

Expression of SMURF2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to SMURF2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating SMURF2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMURF2	hsa-miR-522-3p	84.1821	NM_022739
SMURF2	hsa-miR-224-3p	84.1821	NM_022739
SMURF2	hsa-miR-548aj-5p	84.0248	NM_022739
SMURF2	hsa-miR-548f-5p	84.0248	NM_022739
SMURF2	hsa-miR-548g-5p	84.0248	NM_022739
SMURF2	hsa-miR-548x-5p	84.0248	NM_022739
SMURF2	hsa-miR-12130	83.8251	NM_022739
SMURF2	hsa-miR-5093	83.7941	NM_022739
SMURF2	hsa-miR-518c-5p	83.697	NM_022739
SMURF2	hsa-miR-29b-2-5p	83.4732	NM_022739
SMURF2	hsa-miR-3194-3p	83.1136	NM_022739
SMURF2	hsa-miR-497-5p	83.051	NM_022739
SMURF2	hsa-miR-2392	82.9343	NM_022739
SMURF2	hsa-miR-195-5p	82.0784	NM_022739
SMURF2	hsa-miR-503-5p	82.0784	NM_022739
SMURF2	hsa-miR-16-5p	82.0784	NM_022739
SMURF2	hsa-miR-15b-5p	82.0784	NM_022739
SMURF2	hsa-miR-15a-5p	82.0784	NM_022739
SMURF2	hsa-miR-6516-3p	81.828	NM_022739
SMURF2	hsa-miR-8065	81.7475	NM_022739
SMURF2	hsa-miR-3662	80.9876	NM_022739
SMURF2	hsa-miR-10397-5p	80.8681	NM_022739
SMURF2	hsa-miR-3973	80.7514	NM_022739
SMURF2	hsa-miR-338-5p	80.6069	NM_022739
SMURF2	hsa-miR-1244	80.4201	NM_022739

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating SMURF2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMURF2	metacluster_135.11	NR2C2 (directAnnotation).
SMURF2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SMURF2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SMURF2	metacluster_7.13	ZFX (directAnnotation).
SMURF2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SMURF2	cisbp__M00968	MTF2 (directAnnotation).
SMURF2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMURF2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SMURF2	cisbp__M00341	PAX6 (directAnnotation).
SMURF2	metacluster_198.3	ZFP64 (directAnnotation).
SMURF2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SMURF2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SMURF2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SMURF2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SMURF2	cisbp__M00788	ZFY (inferredBy_Orthology).
SMURF2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SMURF2	metacluster_175.1	ZNF283 (directAnnotation).
SMURF2	hdpi__ZNF304	ZNF304 (directAnnotation).
SMURF2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SMURF2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SMURF2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SMURF2	transfac_pro__M01199	TRIM28 (directAnnotation).
SMURF2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SMURF2	metacluster_151.2	ZNF23 (directAnnotation).
SMURF2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SMURF2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMURF2	transfac_pro__M03806	ZBTB7C (directAnnotation).
SMURF2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."