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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMAD5

Summary for SMAD5

Gene information	Gene symbol	SMAD5
	Ensembl ID	ENSG00000113658
	Entrez ID	4090
	Gene name	SMAD family member 5
	Synonyms	Dwfc\|JV5-1\|MADH5
	Gene type	protein_coding
	UniProtAcc	Q99717

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Dataset with differentially expressed gene: SMAD5

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.256522	2.24e-07

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Expression of SMAD5 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMAD5

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMAD5

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMAD5	hsa-miR-7856-5p	88.2493	NM_001001419
SMAD5	hsa-miR-6809-3p	88.0661	NM_001001419
SMAD5	hsa-miR-590-3p	88.0369	NM_001001419
SMAD5	hsa-miR-6889-3p	87.7222	NM_001001419
SMAD5	hsa-miR-519d-3p	87.6899	NM_001001419
SMAD5	hsa-miR-17-5p	87.6899	NM_001001419
SMAD5	hsa-miR-93-5p	87.6899	NM_001001419
SMAD5	hsa-miR-20b-5p	87.6899	NM_001001419
SMAD5	hsa-miR-106b-5p	87.6265	NM_001001419
SMAD5	hsa-miR-526b-3p	87.6265	NM_001001419
SMAD5	hsa-miR-106a-5p	87.6265	NM_001001419
SMAD5	hsa-miR-20a-5p	87.6265	NM_001001419
SMAD5	hsa-miR-6730-5p	87.4363	NM_001001419
SMAD5	hsa-miR-550b-3p	86.9673	NM_001001419
SMAD5	hsa-miR-3529-3p	86.9242	NM_001001419
SMAD5	hsa-miR-135b-5p	86.7157	NM_001001419
SMAD5	hsa-miR-135a-5p	86.7157	NM_001001419
SMAD5	hsa-miR-19b-3p	86.5957	NM_001001419
SMAD5	hsa-miR-19a-3p	86.5957	NM_001001419
SMAD5	hsa-miR-155-3p	86.3216	NM_001001419
SMAD5	hsa-miR-6529-3p	86.1164	NM_001001419
SMAD5	hsa-miR-338-5p	85.9591	NM_001001419
SMAD5	hsa-miR-550a-3p	85.9009	NM_001001419
SMAD5	hsa-miR-1252-3p	85.4597	NM_001001419
SMAD5	hsa-miR-200c-5p	85.4407	NM_001001419
SMAD5	hsa-miR-3692-3p	85.3182	NM_001001419
SMAD5	hsa-miR-153-5p	85.1734	NM_001001419
SMAD5	hsa-miR-4511	84.8359	NM_001001419
SMAD5	hsa-miR-142-5p	84.3851	NM_001001419
SMAD5	hsa-miR-5590-3p	84.3851	NM_001001419
SMAD5	hsa-miR-376a-2-5p	84.0088	NM_001001419
SMAD5	hsa-miR-519a-3p	82.6255	NM_001001419
SMAD5	hsa-miR-519c-3p	82.6255	NM_001001419
SMAD5	hsa-miR-519b-3p	82.6255	NM_001001419
SMAD5	hsa-miR-5584-3p	82.193	NM_001001419
SMAD5	hsa-miR-548aj-5p	81.9945	NM_001001419
SMAD5	hsa-miR-548x-5p	81.9945	NM_001001419
SMAD5	hsa-miR-548g-5p	81.9945	NM_001001419
SMAD5	hsa-miR-12136	81.1048	NM_001001419
SMAD5	hsa-miR-27a-3p	80.2669	NM_001001419
SMAD5	hsa-miR-9985	80.2669	NM_001001419
SMAD5	hsa-miR-27b-3p	80.2669	NM_001001419
SMAD5	hsa-miR-425-5p	80.238	NM_001001419
SMAD5	hsa-miR-4694-3p	80.1452	NM_001001419
SMAD5	hsa-miR-548f-3p	80.0141	NM_001001419
SMAD5	hsa-miR-548a-3p	80.0141	NM_001001419

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Motifs and transcription factors (TFs) regulating SMAD5

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMAD5	hdpi__TP73	TP73 (directAnnotation).
SMAD5	transfac_pro__M04950	EGR1 (directAnnotation).
SMAD5	metacluster_55.5	ZNF541 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."