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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SMAD4

Summary for SMAD4

Gene information	Gene symbol	SMAD4
	Ensembl ID	ENSG00000141646
	Entrez ID	4089
	Gene name	SMAD family member 4
	Synonyms	DPC4\|MADH4
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SMAD4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.552011	0.00e+00

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Expression of SMAD4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMAD4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SMAD4	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating SMAD4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMAD4	hsa-miR-106a-5p	83.4154	NM_005359
SMAD4	hsa-miR-93-5p	83.4154	NM_005359
SMAD4	hsa-miR-526b-3p	83.4154	NM_005359
SMAD4	hsa-miR-20b-5p	83.4154	NM_005359
SMAD4	hsa-miR-519d-3p	83.4154	NM_005359
SMAD4	hsa-miR-106b-5p	83.4154	NM_005359
SMAD4	hsa-miR-20a-5p	83.4154	NM_005359
SMAD4	hsa-miR-17-5p	83.4154	NM_005359
SMAD4	hsa-miR-6512-3p	83.16	NM_005359
SMAD4	hsa-miR-6720-5p	83.16	NM_005359
SMAD4	hsa-miR-4446-5p	83.1178	NM_005359
SMAD4	hsa-miR-155-3p	83.1055	NM_005359
SMAD4	hsa-miR-3158-5p	82.7279	NM_005359
SMAD4	hsa-miR-6874-3p	82.2621	NM_005359
SMAD4	hsa-miR-148b-5p	82.2621	NM_005359
SMAD4	hsa-miR-373-5p	81.4428	NM_005359
SMAD4	hsa-miR-371b-5p	81.4428	NM_005359
SMAD4	hsa-miR-616-5p	81.4428	NM_005359
SMAD4	hsa-miR-9985	81.1503	NM_005359
SMAD4	hsa-miR-27a-3p	81.1503	NM_005359
SMAD4	hsa-miR-27b-3p	81.1503	NM_005359
SMAD4	hsa-miR-4775	81.1147	NM_005359
SMAD4	hsa-miR-4696	81.0792	NM_005359
SMAD4	hsa-miR-449a	80.6088	NM_005359
SMAD4	hsa-miR-4668-5p	80.5012	NM_005359
SMAD4	hsa-miR-452-5p	80.4522	NM_005359
SMAD4	hsa-miR-892c-3p	80.4522	NM_005359
SMAD4	hsa-miR-4676-3p	80.4522	NM_005359
SMAD4	hsa-miR-6888-3p	80.4239	NM_005359
SMAD4	hsa-miR-4778-5p	80.153	NM_005359

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Motifs and transcription factors (TFs) regulating SMAD4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMAD4	metacluster_135.11	NR2C2 (directAnnotation).
SMAD4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SMAD4	tfdimers__MD00038	TFAP2C (directAnnotation).
SMAD4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SMAD4	metacluster_7.13	ZFX (directAnnotation).
SMAD4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SMAD4	cisbp__M00968	MTF2 (directAnnotation).
SMAD4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMAD4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SMAD4	cisbp__M00341	PAX6 (directAnnotation).
SMAD4	metacluster_198.3	ZFP64 (directAnnotation).
SMAD4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SMAD4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SMAD4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SMAD4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SMAD4	cisbp__M00788	ZFY (inferredBy_Orthology).
SMAD4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SMAD4	metacluster_175.1	ZNF283 (directAnnotation).
SMAD4	hdpi__ZNF304	ZNF304 (directAnnotation).
SMAD4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SMAD4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SMAD4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SMAD4	transfac_pro__M01199	TRIM28 (directAnnotation).
SMAD4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SMAD4	metacluster_151.2	ZNF23 (directAnnotation).
SMAD4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SMAD4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMAD4	transfac_pro__M03806	ZBTB7C (directAnnotation).
SMAD4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."