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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SMAD2

Summary for SMAD2

Gene information	Gene symbol	SMAD2
	Ensembl ID	ENSG00000175387
	Entrez ID	4087
	Gene name	SMAD family member 2
	Synonyms	JV18-1\|MADH2\|MADR2
	Gene type	protein_coding
	UniProtAcc	Q15796

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Dataset with differentially expressed gene: SMAD2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.337248	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.312453	8.30e-43
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.47283	0.00e+00

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Expression of SMAD2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SMAD2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SMAD2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SMAD2	hsa-miR-6716-5p	85.362	NM_001003652
SMAD2	hsa-miR-6731-5p	85.2736	NM_001003652
SMAD2	hsa-miR-8085	85.2736	NM_001003652
SMAD2	hsa-miR-3065-5p	85.2193	NM_001003652
SMAD2	hsa-miR-6074	85.1982	NM_001003652
SMAD2	hsa-miR-450a-1-3p	84.9266	NM_001003652
SMAD2	hsa-miR-4305	84.85	NM_001003652
SMAD2	hsa-miR-34c-3p	84.8284	NM_001003652
SMAD2	hsa-miR-3692-5p	84.5396	NM_001003652
SMAD2	hsa-miR-548c-3p	84.3189	NM_001003652
SMAD2	hsa-miR-767-3p	84.2472	NM_001003652
SMAD2	hsa-miR-3919	84.2281	NM_001003652
SMAD2	hsa-miR-3913-3p	83.8142	NM_001003652
SMAD2	hsa-miR-4298	83.7749	NM_001003652
SMAD2	hsa-miR-374b-5p	83.5815	NM_001003652
SMAD2	hsa-miR-9500	83.5593	NM_001003652
SMAD2	hsa-miR-3671	83.3288	NM_001003652
SMAD2	hsa-miR-93-3p	83.3209	NM_001003652
SMAD2	hsa-miR-3942-3p	83.203	NM_001003652
SMAD2	hsa-miR-365a-5p	83.1341	NM_001003652
SMAD2	hsa-miR-365b-5p	83.1341	NM_001003652
SMAD2	hsa-miR-4724-3p	82.7277	NM_001003652
SMAD2	hsa-miR-409-3p	82.1368	NM_001003652
SMAD2	hsa-miR-769-5p	82.0117	NM_001003652
SMAD2	hsa-miR-497-3p	81.9112	NM_001003652
SMAD2	hsa-miR-5692c	81.8614	NM_001003652
SMAD2	hsa-miR-5692b	81.8614	NM_001003652
SMAD2	hsa-miR-522-3p	81.8501	NM_001003652
SMAD2	hsa-miR-224-3p	81.8501	NM_001003652
SMAD2	hsa-miR-548ag	81.6844	NM_001003652
SMAD2	hsa-miR-548ai	81.6844	NM_001003652
SMAD2	hsa-miR-570-5p	81.6844	NM_001003652
SMAD2	hsa-miR-548ba	81.6844	NM_001003652
SMAD2	hsa-miR-6792-5p	81.6596	NM_001003652
SMAD2	hsa-miR-103a-2-5p	81.0367	NM_001003652
SMAD2	hsa-miR-103a-1-5p	81.0367	NM_001003652
SMAD2	hsa-miR-4773	81.0292	NM_001003652
SMAD2	hsa-miR-302d-5p	80.9762	NM_001003652
SMAD2	hsa-miR-302b-5p	80.9762	NM_001003652
SMAD2	hsa-miR-18a-5p	80.8716	NM_001003652
SMAD2	hsa-miR-18b-5p	80.8716	NM_001003652
SMAD2	hsa-miR-4735-3p	80.8481	NM_001003652
SMAD2	hsa-miR-190b-3p	80.8192	NM_001003652
SMAD2	hsa-miR-12136	80.7721	NM_001003652
SMAD2	hsa-miR-30e-3p	80.4114	NM_001003652
SMAD2	hsa-miR-30a-3p	80.4114	NM_001003652
SMAD2	hsa-miR-30d-3p	80.4114	NM_001003652
SMAD2	hsa-miR-5584-5p	80.2829	NM_001003652
SMAD2	hsa-miR-216a-3p	80.2392	NM_001003652
SMAD2	hsa-miR-128-3p	80.2392	NM_001003652

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Motifs and transcription factors (TFs) regulating SMAD2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SMAD2	metacluster_7.13	ZFX (directAnnotation).
SMAD2	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SMAD2	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SMAD2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SMAD2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
SMAD2	metacluster_151.2	ZNF23 (directAnnotation).
SMAD2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SMAD2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SMAD2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SMAD2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SMAD2	metacluster_182.10	ZFX (directAnnotation).
SMAD2	hdpi__ETV4	ETV4 (directAnnotation).
SMAD2	jaspar__MA0748.2	YY2 (directAnnotation).
SMAD2	transfac_pro__M05628	ZNF735 (directAnnotation).
SMAD2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SMAD2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SMAD2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
SMAD2	jaspar__MA0079.5	SP1 (directAnnotation).
SMAD2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
SMAD2	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SMAD2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SMAD2	transfac_pro__M07397	ZNF148 (directAnnotation).
SMAD2	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
SMAD2	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
SMAD2	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
SMAD2	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SMAD2	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SMAD2	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
SMAD2	transfac_pro__M01175	ZBTB7B (directAnnotation).
SMAD2	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SMAD2	tfdimers__MD00151	CHURC1 (directAnnotation).
SMAD2	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SMAD2	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SMAD2	transfac_pro__M01303	SP1 (directAnnotation).
SMAD2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SMAD2	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SMAD2	transfac_pro__M02090	E2F4 (directAnnotation).
SMAD2	transfac_pro__M01714	KLF15 (directAnnotation).
SMAD2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
SMAD2	jaspar__MA1122.1	TFDP1 (directAnnotation).
SMAD2	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
SMAD2	transfac_pro__M02089	E2F3 (directAnnotation).
SMAD2	transfac_pro__M12604	ZNF444 (directAnnotation).
SMAD2	metacluster_3.14	WT1; WT1 (directAnnotation).
SMAD2	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
SMAD2	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
SMAD2	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
SMAD2	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SMAD2	cisbp__M07938	E2F1 (directAnnotation).
SMAD2	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SMAD2	"Dexfosfoserine"	DB04522	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."