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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: SLC8A1

Summary for SLC8A1

Gene information	Gene symbol	SLC8A1
	Ensembl ID	ENSG00000183023
	Entrez ID	6546
	Gene name	solute carrier family 8 member A1
	Synonyms	NCX1
	Gene type	protein_coding
	UniProtAcc	P32418

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Dataset with differentially expressed gene: SLC8A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.372898	9.27e-34

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Expression of SLC8A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC8A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC8A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC8A1	hsa-miR-3688-3p	83.8682	NM_001112800
SLC8A1	hsa-miR-150-5p	83.5386	NM_001112800
SLC8A1	hsa-miR-4487	83.384	NM_001112800
SLC8A1	hsa-miR-3160-3p	83.384	NM_001112800
SLC8A1	hsa-miR-206	82.3601	NM_001112800
SLC8A1	hsa-miR-1-3p	82.3601	NM_001112800
SLC8A1	hsa-miR-6785-5p	82.3055	NM_001112800
SLC8A1	hsa-miR-3977	82.2443	NM_001112800
SLC8A1	hsa-miR-6508-3p	81.017	NM_001112800
SLC8A1	hsa-miR-8069	80.9035	NM_001112800
SLC8A1	hsa-miR-5582-5p	80.892	NM_001112800
SLC8A1	hsa-miR-6779-5p	80.851	NM_001112800

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Motifs and transcription factors (TFs) regulating SLC8A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
SLC8A1	"alpha-Linolenic acid"	DB00132	small molecule
SLC8A1	"Caldaret"	DB06231	small molecule
SLC8A1	"Dronedarone"	DB04855	small molecule
SLC8A1	"Icosapent"	DB00159	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."