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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC4A4

Summary for SLC4A4

Gene information	Gene symbol	SLC4A4
	Ensembl ID	ENSG00000080493
	Entrez ID	8671
	Gene name	solute carrier family 4 member 4
	Synonyms	hhNMC\|HNBC1\|NBC1\|NBC2\|pNBC\|SLC4A5
	Gene type	protein_coding
	UniProtAcc	Q9Y6R1

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Dataset with differentially expressed gene: SLC4A4

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.67252	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.616822	0.00e+00

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Expression of SLC4A4 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC4A4

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
SLC4A4	Irregularity in Drug Uptake and Drug Efflux

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MicroRNAs (miRNA) regulating SLC4A4

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC4A4	hsa-miR-6779-3p	90.0941	NM_001098484
SLC4A4	hsa-miR-4735-5p	89.6993	NM_003759
SLC4A4	hsa-miR-651-5p	89.6848	NM_001134742
SLC4A4	hsa-miR-370-3p	89.1743	NM_001098484
SLC4A4	hsa-miR-6893-3p	89.1743	NM_001098484
SLC4A4	hsa-miR-335-3p	88.9747	NM_001098484
SLC4A4	hsa-miR-7161-5p	88.8714	NM_001134742
SLC4A4	hsa-miR-26a-2-3p	88.8157	NM_003759
SLC4A4	hsa-miR-26a-1-3p	88.8157	NM_003759
SLC4A4	hsa-miR-4268	88.6452	NM_001098484
SLC4A4	hsa-miR-587	88.2634	NM_001098484
SLC4A4	hsa-miR-26a-5p	87.6408	NM_003759
SLC4A4	hsa-miR-26b-5p	87.6408	NM_003759
SLC4A4	hsa-miR-548u	87.5734	NM_001134742
SLC4A4	hsa-miR-3123	87.2162	NM_001134742
SLC4A4	hsa-miR-3065-5p	87.0667	NM_001134742
SLC4A4	hsa-miR-4319	87.0275	NM_001098484
SLC4A4	hsa-miR-4465	86.9022	NM_003759
SLC4A4	hsa-miR-15b-5p	86.832	NM_001098484
SLC4A4	hsa-miR-16-5p	86.832	NM_001098484
SLC4A4	hsa-miR-195-5p	86.832	NM_001098484
SLC4A4	hsa-miR-15a-5p	86.832	NM_001098484
SLC4A4	hsa-miR-1277-5p	85.983	NM_001134742
SLC4A4	hsa-miR-376b-3p	85.8602	NM_001098484
SLC4A4	hsa-miR-376a-3p	85.8602	NM_001098484
SLC4A4	hsa-miR-5700	85.0375	NM_001134742
SLC4A4	hsa-miR-3118	84.8841	NM_003759
SLC4A4	hsa-miR-134-5p	84.8841	NM_003759
SLC4A4	hsa-miR-1304-5p	84.7425	NM_001098484
SLC4A4	hsa-miR-1205	84.5762	NM_001098484
SLC4A4	hsa-miR-10394-5p	84.5762	NM_001098484
SLC4A4	hsa-miR-4773	84.3966	NM_001134742
SLC4A4	hsa-miR-29b-2-5p	84.2884	NM_001098484
SLC4A4	hsa-miR-383-3p	84.1457	NM_001098484
SLC4A4	hsa-miR-511-5p	84.0358	NM_003759
SLC4A4	hsa-miR-448	83.6536	NM_001098484
SLC4A4	hsa-miR-217-5p	83.0182	NM_001098484
SLC4A4	hsa-miR-582-5p	82.8197	NM_001098484
SLC4A4	hsa-miR-6730-5p	82.623	NM_001134742
SLC4A4	hsa-miR-6739-3p	82.363	NM_001098484
SLC4A4	hsa-miR-4666a-3p	82.3097	NM_001134742
SLC4A4	hsa-miR-497-5p	82.2945	NM_001098484
SLC4A4	hsa-miR-424-5p	82.2945	NM_001098484
SLC4A4	hsa-miR-6838-5p	82.2945	NM_001098484
SLC4A4	hsa-miR-150-5p	81.9531	NM_001098484
SLC4A4	hsa-miR-6822-3p	81.8502	NM_001134742
SLC4A4	hsa-miR-5002-5p	81.8455	NM_001098484
SLC4A4	hsa-miR-10523-5p	81.6409	NM_003759
SLC4A4	hsa-miR-33a-3p	81.4503	NM_001134742
SLC4A4	hsa-miR-6867-5p	81.3241	NM_001134742

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Motifs and transcription factors (TFs) regulating SLC4A4

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC4A4	metacluster_135.11	NR2C2 (directAnnotation).
SLC4A4	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SLC4A4	tfdimers__MD00038	TFAP2C (directAnnotation).
SLC4A4	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SLC4A4	metacluster_7.13	ZFX (directAnnotation).
SLC4A4	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SLC4A4	cisbp__M00968	MTF2 (directAnnotation).
SLC4A4	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SLC4A4	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SLC4A4	cisbp__M00341	PAX6 (directAnnotation).
SLC4A4	metacluster_198.3	ZFP64 (directAnnotation).
SLC4A4	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SLC4A4	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SLC4A4	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SLC4A4	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SLC4A4	cisbp__M00788	ZFY (inferredBy_Orthology).
SLC4A4	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SLC4A4	metacluster_175.1	ZNF283 (directAnnotation).
SLC4A4	hdpi__ZNF304	ZNF304 (directAnnotation).
SLC4A4	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SLC4A4	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SLC4A4	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SLC4A4	transfac_pro__M01199	TRIM28 (directAnnotation).
SLC4A4	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SLC4A4	metacluster_151.2	ZNF23 (directAnnotation).
SLC4A4	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SLC4A4	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SLC4A4	transfac_pro__M03806	ZBTB7C (directAnnotation).
SLC4A4	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SLC4A4	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SLC4A4	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
SLC4A4	transfac_pro__M02089	E2F3 (directAnnotation).
SLC4A4	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SLC4A4	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SLC4A4	transfac_pro__M04817	ZBTB33 (directAnnotation).
SLC4A4	metacluster_143.13	ZBTB7A (directAnnotation).
SLC4A4	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
SLC4A4	tfdimers__MD00483	ZBTB14 (directAnnotation).
SLC4A4	cisbp__M07938	E2F1 (directAnnotation).
SLC4A4	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
SLC4A4	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SLC4A4	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SLC4A4	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SLC4A4	jaspar__MA1122.1	TFDP1 (directAnnotation).
SLC4A4	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."