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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC44A1

Summary for SLC44A1

Gene information	Gene symbol	SLC44A1
	Ensembl ID	ENSG00000070214
	Entrez ID	23446
	Gene name	solute carrier family 44 member 1
	Synonyms	CD92\|CDW92\|CHTL1\|CTL1
	Gene type	protein_coding
	UniProtAcc	Q8WWI5

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Dataset with differentially expressed gene: SLC44A1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.83001	0.00e+00
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.250317	1.45e-11
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.460162	4.59e-32
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.378428	0.00e+00

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Expression of SLC44A1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC44A1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC44A1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC44A1	hsa-miR-587	87.3861	NM_080546
SLC44A1	hsa-miR-3929	87.0903	NM_001286730
SLC44A1	hsa-miR-146a-3p	86.9899	NM_080546
SLC44A1	hsa-miR-28-3p	86.9456	NM_001286730
SLC44A1	hsa-miR-4653-5p	86.6718	NM_080546
SLC44A1	hsa-miR-3921	86.6718	NM_080546
SLC44A1	hsa-miR-5197-5p	86.4546	NM_001286730
SLC44A1	hsa-miR-3133	86.3198	NM_080546
SLC44A1	hsa-miR-4789-3p	86.2703	NM_080546
SLC44A1	hsa-miR-647	86.1532	NM_080546
SLC44A1	hsa-miR-3942-3p	85.8609	NM_080546
SLC44A1	hsa-miR-4282	85.6586	NM_001286730
SLC44A1	hsa-miR-4666a-5p	85.2701	NM_080546
SLC44A1	hsa-miR-4329	84.9047	NM_001286730
SLC44A1	hsa-miR-329-3p	84.645	NM_080546
SLC44A1	hsa-miR-362-3p	84.645	NM_080546
SLC44A1	hsa-miR-208b-5p	84.5641	NM_001286730
SLC44A1	hsa-miR-208a-5p	84.5641	NM_001286730
SLC44A1	hsa-miR-3919	84.4698	NM_001286730
SLC44A1	hsa-miR-4789-5p	84.1113	NM_080546
SLC44A1	hsa-miR-539-5p	83.9613	NM_001286730
SLC44A1	hsa-miR-3646	83.8663	NM_080546
SLC44A1	hsa-miR-6815-3p	83.8317	NM_080546
SLC44A1	hsa-miR-1236-3p	83.4582	NM_001286730
SLC44A1	hsa-miR-5691	83.3165	NM_080546
SLC44A1	hsa-miR-6805-3p	83.3165	NM_080546
SLC44A1	hsa-miR-3160-5p	83.0156	NM_080546
SLC44A1	hsa-miR-548c-3p	82.772	NM_080546
SLC44A1	hsa-miR-544b	82.3882	NM_080546
SLC44A1	hsa-miR-7853-5p	82.2717	NM_080546
SLC44A1	hsa-miR-105-5p	82.2717	NM_080546
SLC44A1	hsa-miR-561-3p	82.1359	NM_080546
SLC44A1	hsa-miR-3613-3p	82.0779	NM_080546
SLC44A1	hsa-miR-4312	81.8836	NM_080546
SLC44A1	hsa-miR-4251	81.4422	NM_001286730
SLC44A1	hsa-miR-7850-5p	81.139	NM_080546
SLC44A1	hsa-miR-607	80.5296	NM_080546
SLC44A1	hsa-miR-6742-5p	80.4901	NM_001286730
SLC44A1	hsa-miR-5688	80.4662	NM_080546
SLC44A1	hsa-miR-337-3p	80.3662	NM_001286730
SLC44A1	hsa-miR-589-3p	80.2326	NM_001286730
SLC44A1	hsa-miR-548h-3p	80.2224	NM_001286730
SLC44A1	hsa-miR-548ac	80.2224	NM_001286730
SLC44A1	hsa-miR-548z	80.2224	NM_001286730
SLC44A1	hsa-miR-548d-3p	80.2224	NM_001286730
SLC44A1	hsa-miR-548bb-3p	80.2224	NM_001286730

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Motifs and transcription factors (TFs) regulating SLC44A1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC44A1	metacluster_7.13	ZFX (directAnnotation).
SLC44A1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SLC44A1	metacluster_151.2	ZNF23 (directAnnotation).
SLC44A1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SLC44A1	transfac_pro__M05479	ZNF580 (directAnnotation).
SLC44A1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SLC44A1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SLC44A1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SLC44A1	hdpi__ETV4	ETV4 (directAnnotation).
SLC44A1	jaspar__MA0748.2	YY2 (directAnnotation).
SLC44A1	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SLC44A1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SLC44A1	jaspar__MA0079.5	SP1 (directAnnotation).
SLC44A1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
SLC44A1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
SLC44A1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SLC44A1	transfac_pro__M01122	ZNF219 (directAnnotation).
SLC44A1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SLC44A1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SLC44A1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
SLC44A1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SLC44A1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
SLC44A1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
SLC44A1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
SLC44A1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SLC44A1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
SLC44A1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SLC44A1	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
SLC44A1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SLC44A1	metacluster_84.2	RARA (directAnnotation).
SLC44A1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
SLC44A1	transfac_pro__M01253	CNOT3 (directAnnotation).
SLC44A1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
SLC44A1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
SLC44A1	jaspar__MA1721.1	ZNF93 (directAnnotation).
SLC44A1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SLC44A1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SLC44A1	homer__AAGGKGRCGCAGGCA_ZNF165	ZNF165 (directAnnotation).
SLC44A1	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
SLC44A1	kznf__ZNF311_Imbeault2017_OM_MEME	ZNF311 (directAnnotation).
SLC44A1	jaspar__MA1122.1	TFDP1 (directAnnotation).
SLC44A1	cisbp__M00341	PAX6 (directAnnotation).
SLC44A1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
SLC44A1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWGNNNNNTCCGGNN_CAP	GCM1; SPDEF (directAnnotation).
SLC44A1	transfac_pro__M01199	TRIM28 (directAnnotation).
SLC44A1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
SLC44A1	metacluster_35.2	EGR1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF3; ELF4; ELF4; ELK1; ELK3; ELK4; ERG; ETS1; ETS1; ETS2; ETV1; ETV1; ETV5; ETV5; ETV6; FLI1; FLI1; GABPA; GABPA; GABPA; GABPB1; GABPB1; GABPB1; ZBTB7A (directAnnotation). ELF2; ELF2; ERG; ERG; ETS2; FLI1; GABPA; IKZF3; SPIC (inferredBy_Orthology).
SLC44A1	tfdimers__MD00151	CHURC1 (directAnnotation).
SLC44A1	tfdimers__MD00391	KLF4 (directAnnotation).
SLC44A1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."