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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLC39A10

Summary for SLC39A10

Gene information	Gene symbol	SLC39A10
	Ensembl ID	ENSG00000196950
	Entrez ID	57181
	Gene name	solute carrier family 39 member 10
	Synonyms	DKFZp564L2123\|FLJ90515\|KIAA1265
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SLC39A10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.792395	8.87e-07
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.371722	0.00e+00

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Expression of SLC39A10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLC39A10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLC39A10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLC39A10	hsa-miR-3163	83.8281	NM_020342
SLC39A10	hsa-let-7f-1-3p	83.2783	NM_020342
SLC39A10	hsa-miR-98-3p	83.2783	NM_020342
SLC39A10	hsa-let-7a-3p	83.2783	NM_020342
SLC39A10	hsa-let-7b-3p	83.2783	NM_020342
SLC39A10	hsa-miR-6856-3p	83.1493	NM_001127257
SLC39A10	hsa-miR-1284	83.0577	NM_020342
SLC39A10	hsa-miR-4514	82.8565	NM_001127257
SLC39A10	hsa-miR-934	82.7697	NM_020342
SLC39A10	hsa-miR-625-3p	82.6119	NM_020342
SLC39A10	hsa-miR-6124	82.5866	NM_020342
SLC39A10	hsa-miR-497-5p	82.5233	NM_001127257
SLC39A10	hsa-miR-424-5p	82.5233	NM_001127257
SLC39A10	hsa-miR-6838-5p	82.5233	NM_001127257
SLC39A10	hsa-miR-6757-3p	82.2462	NM_001127257
SLC39A10	hsa-miR-936	82.2205	NM_001127257
SLC39A10	hsa-miR-1286	81.7785	NM_020342
SLC39A10	hsa-miR-544a	81.5119	NM_001127257
SLC39A10	hsa-miR-505-5p	81.4343	NM_020342
SLC39A10	hsa-miR-449b-3p	81.3962	NM_001127257
SLC39A10	hsa-miR-8485	81.0663	NM_020342
SLC39A10	hsa-miR-548ar-3p	80.1089	NM_020342

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Motifs and transcription factors (TFs) regulating SLC39A10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLC39A10	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
SLC39A10	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
SLC39A10	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
SLC39A10	transfac_pro__M04617	ZBTB7A (directAnnotation).
SLC39A10	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
SLC39A10	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
SLC39A10	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
SLC39A10	transfac_pro__M07387	ZBTB7A (directAnnotation).
SLC39A10	transfac_pro__M07436	WT1 (directAnnotation).
SLC39A10	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
SLC39A10	transfac_pro__M00716	ZBTB14 (directAnnotation).
SLC39A10	swissregulon__hs__CHD1	CHD1 (directAnnotation).
SLC39A10	hdpi__HIP2	UBE2K (directAnnotation).
SLC39A10	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
SLC39A10	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SLC39A10	transfac_pro__M04893	TAF1 (directAnnotation).
SLC39A10	transfac_pro__M03876	ZBTB33 (directAnnotation).
SLC39A10	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
SLC39A10	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SLC39A10	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
SLC39A10	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SLC39A10	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
SLC39A10	taipale_tf_pairs__E2F3_HES7_NNNNGCGCSNNNNNCACGTGNN_CAP	E2F3; HES7 (directAnnotation).
SLC39A10	transfac_pro__M02089	E2F3 (directAnnotation).
SLC39A10	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SLC39A10	transfac_pro__M04817	ZBTB33 (directAnnotation).
SLC39A10	metacluster_143.13	ZBTB7A (directAnnotation).
SLC39A10	transfac_pro__M02861	GATA6 (inferredBy_Orthology).
SLC39A10	tfdimers__MD00483	ZBTB14 (directAnnotation).
SLC39A10	cisbp__M07938	E2F1 (directAnnotation).
SLC39A10	cisbp__M00968	MTF2 (directAnnotation).
SLC39A10	jaspar__MA0535.1	SMAD9 (inferredBy_Orthology).
SLC39A10	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
SLC39A10	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
SLC39A10	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
SLC39A10	jaspar__MA1122.1	TFDP1 (directAnnotation).
SLC39A10	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."