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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SLAIN2

Summary for SLAIN2

Gene information	Gene symbol	SLAIN2
	Ensembl ID	ENSG00000109171
	Entrez ID	57606
	Gene name	SLAIN motif family member 2
	Synonyms	FLJ21611\|KIAA1458
	Gene type	protein_coding
	UniProtAcc	Q9P270

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Dataset with differentially expressed gene: SLAIN2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	B cells	-0.38837	5.97e-04
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.31352	3.92e-44

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Expression of SLAIN2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SLAIN2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SLAIN2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SLAIN2	hsa-miR-512-3p	92.1982	NM_020846
SLAIN2	hsa-miR-3163	92.1495	NM_020846
SLAIN2	hsa-miR-6828-3p	91.9912	NM_020846
SLAIN2	hsa-miR-8066	91.9672	NM_020846
SLAIN2	hsa-miR-7156-3p	91.8733	NM_020846
SLAIN2	hsa-miR-520d-3p	91.855	NM_020846
SLAIN2	hsa-miR-520a-3p	91.855	NM_020846
SLAIN2	hsa-miR-520b-3p	91.855	NM_020846
SLAIN2	hsa-miR-372-3p	91.855	NM_020846
SLAIN2	hsa-miR-520c-3p	91.855	NM_020846
SLAIN2	hsa-miR-548o-3p	91.7764	NM_020846
SLAIN2	hsa-miR-140-3p	91.3303	NM_020846
SLAIN2	hsa-miR-106a-5p	91.1418	NM_020846
SLAIN2	hsa-miR-519d-3p	91.1418	NM_020846
SLAIN2	hsa-miR-93-5p	91.1418	NM_020846
SLAIN2	hsa-miR-20b-5p	91.1418	NM_020846
SLAIN2	hsa-miR-17-5p	91.1418	NM_020846
SLAIN2	hsa-miR-526b-3p	91.1418	NM_020846
SLAIN2	hsa-miR-3686	90.6931	NM_020846
SLAIN2	hsa-miR-561-5p	90.6271	NM_020846
SLAIN2	hsa-miR-508-3p	90.6116	NM_020846
SLAIN2	hsa-miR-4482-3p	90.5232	NM_020846
SLAIN2	hsa-miR-153-5p	90.1369	NM_020846
SLAIN2	hsa-miR-4789-5p	90.1056	NM_020846
SLAIN2	hsa-miR-103a-3p	90.0703	NM_020846
SLAIN2	hsa-miR-107	90.0703	NM_020846
SLAIN2	hsa-miR-5000-5p	89.6363	NM_020846
SLAIN2	hsa-miR-4423-3p	89.5868	NM_020846
SLAIN2	hsa-miR-1185-1-3p	89.573	NM_020846
SLAIN2	hsa-let-7f-2-3p	89.573	NM_020846
SLAIN2	hsa-miR-1185-2-3p	89.573	NM_020846
SLAIN2	hsa-miR-4668-3p	89.5255	NM_020846
SLAIN2	hsa-miR-552-5p	89.1721	NM_020846
SLAIN2	hsa-miR-148b-5p	89.0829	NM_020846
SLAIN2	hsa-miR-6874-3p	89.0829	NM_020846
SLAIN2	hsa-miR-4526	89.0259	NM_020846
SLAIN2	hsa-miR-590-3p	89.0133	NM_020846
SLAIN2	hsa-miR-3660	88.8959	NM_020846
SLAIN2	hsa-miR-182-5p	88.4737	NM_020846
SLAIN2	hsa-miR-4693-3p	88.2144	NM_020846
SLAIN2	hsa-miR-3935	88.1856	NM_020846
SLAIN2	hsa-miR-4642	87.9451	NM_020846
SLAIN2	hsa-miR-12136	87.8706	NM_020846
SLAIN2	hsa-miR-6878-3p	87.4601	NM_020846
SLAIN2	hsa-miR-3168	87.125	NM_020846
SLAIN2	hsa-miR-5584-3p	86.8853	NM_020846
SLAIN2	hsa-miR-4735-5p	86.534	NM_020846
SLAIN2	hsa-miR-448	86.2728	NM_020846
SLAIN2	hsa-miR-605-5p	85.7061	NM_020846
SLAIN2	hsa-miR-4796-3p	85.6559	NM_020846

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Motifs and transcription factors (TFs) regulating SLAIN2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SLAIN2	metacluster_7.13	ZFX (directAnnotation).
SLAIN2	cisbp__M01863	ZNF711 (inferredBy_Orthology).
SLAIN2	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SLAIN2	metacluster_151.2	ZNF23 (directAnnotation).
SLAIN2	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
SLAIN2	transfac_pro__M05479	ZNF580 (directAnnotation).
SLAIN2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SLAIN2	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
SLAIN2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SLAIN2	hdpi__ETV4	ETV4 (directAnnotation).
SLAIN2	jaspar__MA0748.2	YY2 (directAnnotation).
SLAIN2	transfac_pro__M05628	ZNF735 (directAnnotation).
SLAIN2	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
SLAIN2	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
SLAIN2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SLAIN2	taipale_tf_pairs__GCM1_SPDEF_RTRSKGGCGGANNNNNNATCCNNN_CAP_repr	GCM1; SPDEF (directAnnotation).
SLAIN2	jaspar__MA1933.1	SREBF2 (directAnnotation).
SLAIN2	jaspar__MA0079.5	SP1 (directAnnotation).
SLAIN2	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
SLAIN2	metacluster_107.1	CERS2; CERS3; CERS4; CERS5; CERS6 (inferredBy_Orthology).
SLAIN2	metacluster_168.18	ZNF214; ZNF239; ZNF45; ZNF696 (directAnnotation).
SLAIN2	transfac_pro__M05858	ZNF625 (directAnnotation).
SLAIN2	dbtfbs__ZFP91_K562_ENCSR898XMH_merged_N1	ZFP91 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."