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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SKIL

Summary for SKIL

Gene information	Gene symbol	SKIL
	Ensembl ID	ENSG00000136603
	Entrez ID	6498
	Gene name	SKI like proto-oncogene
	Synonyms	SNO\|SnoA\|SnoN
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SKIL

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.549114	0.00e+00
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD8+ T cells	0.287311	2.52e-37
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.387529	7.61e-08
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	pre	B cells	-0.259422	4.81e-06
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	-0.373625	4.26e-02
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	-0.533819	1.82e-44
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.480105	4.97e-11
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.407052	3.41e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Neutrophils	0.417459	1.63e-06
GSE161801_PI	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	carfilzomib + dexamethasone	pre	CD8+ T cells	0.335721	0.00e+00
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.295647	3.75e-20
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.350168	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.740712	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.413089	8.30e-08

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Expression of SKIL in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SKIL

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SKIL

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SKIL	hsa-let-7d-5p	95.1244	NM_001145097
SKIL	hsa-miR-12129	95.0452	NM_001145097
SKIL	hsa-miR-4328	94.7854	NM_001145097
SKIL	hsa-miR-4799-5p	94.3232	NM_001145097
SKIL	hsa-miR-4694-3p	94.2017	NM_001145097
SKIL	hsa-miR-1305	94.1125	NM_001145097
SKIL	hsa-miR-1284	94.037	NM_001145097
SKIL	hsa-miR-5093	93.5177	NM_001145097
SKIL	hsa-miR-5680	93.4077	NM_001145097
SKIL	hsa-miR-5582-3p	93.1452	NM_001145097
SKIL	hsa-miR-5008-3p	93.1018	NM_001145097
SKIL	hsa-miR-548bb-3p	93.057	NM_001145097
SKIL	hsa-miR-548ac	93.057	NM_001145097
SKIL	hsa-miR-548d-3p	93.057	NM_001145097
SKIL	hsa-miR-548h-3p	93.057	NM_001145097
SKIL	hsa-miR-548z	93.057	NM_001145097
SKIL	hsa-miR-7157-3p	92.9832	NM_001145097
SKIL	hsa-miR-6737-3p	92.9832	NM_001145097
SKIL	hsa-miR-5047	92.8983	NM_001145097
SKIL	hsa-miR-1301-3p	92.8983	NM_001145097
SKIL	hsa-miR-582-3p	92.8868	NM_001145097
SKIL	hsa-miR-4642	92.799	NM_001145097
SKIL	hsa-miR-561-5p	92.751	NM_001145097
SKIL	hsa-miR-656-3p	92.508	NM_001145097
SKIL	hsa-miR-10527-5p	92.1502	NM_001145097
SKIL	hsa-miR-548p	92.084	NM_001145097
SKIL	hsa-miR-3688-3p	92.0307	NM_001145097
SKIL	hsa-miR-95-5p	91.9201	NM_001145097
SKIL	hsa-miR-7-1-3p	91.7334	NM_001145097
SKIL	hsa-miR-7-2-3p	91.7334	NM_001145097
SKIL	hsa-miR-8485	91.1927	NM_001145097
SKIL	hsa-miR-298	90.6897	NM_001145097
SKIL	hsa-miR-12136	90.6053	NM_001145097
SKIL	hsa-miR-6882-5p	90.315	NM_001145097
SKIL	hsa-miR-3148	90.2402	NM_001145097
SKIL	hsa-miR-664b-3p	88.9949	NM_001145097
SKIL	hsa-miR-579-3p	88.9949	NM_001145097
SKIL	hsa-miR-3121-3p	88.8404	NM_001145097
SKIL	hsa-miR-127-5p	88.815	NM_001145097
SKIL	hsa-miR-590-3p	88.777	NM_001145097
SKIL	hsa-miR-182-5p	88.6763	NM_001145097
SKIL	hsa-miR-4699-3p	88.5948	NM_001145097
SKIL	hsa-miR-567	88.0481	NM_001145097
SKIL	hsa-miR-7844-5p	88.0428	NM_001145097
SKIL	hsa-miR-29a-5p	87.9261	NM_001145097
SKIL	hsa-miR-548aa	87.5534	NM_001145097
SKIL	hsa-miR-548t-3p	87.5534	NM_001145097
SKIL	hsa-miR-548ap-3p	87.5534	NM_001145097
SKIL	hsa-miR-524-5p	87.543	NM_001145097
SKIL	hsa-miR-520d-5p	87.543	NM_001145097

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Motifs and transcription factors (TFs) regulating SKIL

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SKIL	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SKIL	taipale_tf_pairs__CEBPG_ATF4_NNATGAYGCAAT_CAP	ATF4; CEBPG (directAnnotation).
SKIL	transfac_public__M00491	PATZ1 (directAnnotation).
SKIL	transfac_pro__M05574	ZFP92 (directAnnotation).
SKIL	transfac_pro__M06071	ZNF814 (directAnnotation).
SKIL	tfdimers__MD00302	IRF7; IRF8 (directAnnotation).
SKIL	tfdimers__MD00084	ARID3A; NKX2-4 (directAnnotation).
SKIL	metacluster_82.5	ZKSCAN8; ZNF205; ZNF227; ZNF594 (directAnnotation).
SKIL	metacluster_126.14	ZBTB12; ZBTB12 (directAnnotation).
SKIL	transfac_pro__M05782	ZNF324B (directAnnotation).
SKIL	kznf__ZNF613_Imbeault2017_RP_RCADE	ZNF613 (directAnnotation).
SKIL	transfac_pro__M01252	E2F6 (directAnnotation).
SKIL	jaspar__MA1125.1	ZNF384 (directAnnotation).
SKIL	metacluster_130.3	ZNF492; ZNF492 (directAnnotation). OVOL2; OVOL3; PEG3; PLAG1; PLAGL1; PLAGL2; REST; SCAND1; ZKSCAN2; ZNF131; ZNF174; ZNF18; ZNF202; ZNF274; ZNF444; ZNF446; ZNF496; ZNF518A; ZNF518B; ZNF576; ZNF641; ZNF770; ZSCAN1; ZSCAN18; ZSCAN29; ZSCAN32; ZSCAN5A; ZSCAN5B; ZSCAN5C (inferredBy_Orthology).
SKIL	metacluster_130.2	ZNF182; ZNF22; ZNF225; ZNF225; ZNF285; ZNF362; ZNF362; ZNF384; ZNF487; ZNF512; ZNF570; ZNF613 (directAnnotation). ZNF384 (inferredBy_Orthology).
SKIL	hocomoco__BPTF_HUMAN.H11MO.0.D	BPTF (directAnnotation).
SKIL	hdpi__ENO1	ENO1 (directAnnotation).
SKIL	transfac_pro__M03849	SOX4 (directAnnotation).
SKIL	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
SKIL	taipale_cyt_meth__CREB1_NRTGACGTN_eDBD_repr	CREB1 (directAnnotation).
SKIL	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
SKIL	transfac_pro__M01253	CNOT3 (directAnnotation).
SKIL	metacluster_137.2	ATF3; BACH2; BATF; BATF; BATF; BATF; BATF3; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOS; FOSB; FOSB; FOSB; FOSB; FOSB; FOSL1; FOSL1; FOSL1; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; FOSL2; INSM2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUNB; JUNB; JUNB; JUNB; JUND; JUND; JUND; JUND; JUND; SMARCC1 (directAnnotation). ATF3; ATF3; BATF; FOS; FOSB; FOSL1; FOSL1; FOSL2; FOSL2; FOSL2; JUN; JUN; JUN; JUN; JUN; JUN; JUN; JUNB; JUND; JUND; JUND; JUND (inferredBy_Orthology).
SKIL	transfac_pro__M02089	E2F3 (directAnnotation).
SKIL	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
SKIL	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SKIL	transfac_pro__M04916	TAF1 (directAnnotation).
SKIL	transfac_pro__M12697	ZNF142 (directAnnotation).
SKIL	metacluster_111.5	E4F1; E4F1 (directAnnotation).
SKIL	metacluster_135.11	NR2C2 (directAnnotation).
SKIL	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SKIL	tfdimers__MD00038	TFAP2C (directAnnotation).
SKIL	metacluster_7.13	ZFX (directAnnotation).
SKIL	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SKIL	cisbp__M00968	MTF2 (directAnnotation).
SKIL	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SKIL	cisbp__M00341	PAX6 (directAnnotation).
SKIL	metacluster_198.3	ZFP64 (directAnnotation).
SKIL	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SKIL	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SKIL	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SKIL	cisbp__M00788	ZFY (inferredBy_Orthology).
SKIL	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SKIL	metacluster_175.1	ZNF283 (directAnnotation).
SKIL	hdpi__ZNF304	ZNF304 (directAnnotation).
SKIL	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SKIL	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SKIL	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SKIL	transfac_pro__M01199	TRIM28 (directAnnotation).
SKIL	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."