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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SINHCAF

Summary for SINHCAF

Gene information	Gene symbol	SINHCAF
	Ensembl ID	ENSG00000276371
	Entrez ID	58516
	Gene name	SIN3-HDAC complex associated factor
	Synonyms	C12orf14\|FAM60A\|TERA
	Gene type	protein_coding
	UniProtAcc	Q9NP50

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Dataset with differentially expressed gene: SINHCAF

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.265297	5.96e-08
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	-0.316437	1.77e-11
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	-0.432349	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.273555	1.20e-14

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Expression of SINHCAF in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SINHCAF

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SINHCAF

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SINHCAF	hsa-miR-548aj-3p	84.6518	NM_001135811
SINHCAF	hsa-miR-4688	84.6382	NM_001135811
SINHCAF	hsa-miR-302a-5p	84.5866	NM_001135811
SINHCAF	hsa-miR-5699-5p	84.4945	NM_001135811
SINHCAF	hsa-miR-583	84.1374	NM_001135811
SINHCAF	hsa-miR-520h	84.0899	NM_001135811
SINHCAF	hsa-miR-520g-3p	84.0899	NM_001135811
SINHCAF	hsa-miR-548n	83.8203	NM_001135811
SINHCAF	hsa-miR-340-3p	83.7032	NM_001135811
SINHCAF	hsa-miR-143-3p	83.6082	NM_001135811
SINHCAF	hsa-miR-4770	83.6082	NM_001135811
SINHCAF	hsa-miR-6088	83.6082	NM_001135811
SINHCAF	hsa-miR-509-5p	83.4071	NM_001135811
SINHCAF	hsa-miR-509-3-5p	83.4071	NM_001135811
SINHCAF	hsa-miR-5582-3p	83.0065	NM_001135811
SINHCAF	hsa-miR-101-3p	82.5223	NM_001135811
SINHCAF	hsa-miR-6783-5p	82.4835	NM_001135811
SINHCAF	hsa-miR-5584-5p	82.3625	NM_001135811
SINHCAF	hsa-miR-4668-5p	82.175	NM_001135811
SINHCAF	hsa-miR-6743-5p	82.1074	NM_001135811
SINHCAF	hsa-miR-548j-3p	81.9852	NM_001135811
SINHCAF	hsa-miR-548aq-3p	81.9852	NM_001135811
SINHCAF	hsa-miR-548ae-3p	81.9852	NM_001135811
SINHCAF	hsa-miR-203a-5p	81.5941	NM_001135811
SINHCAF	hsa-miR-4263	81.0566	NM_001135811
SINHCAF	hsa-miR-4430	80.4042	NM_001135811
SINHCAF	hsa-miR-3652	80.4042	NM_001135811
SINHCAF	hsa-miR-4418	80.2571	NM_001135811
SINHCAF	hsa-miR-548a-3p	80.2151	NM_001135811
SINHCAF	hsa-miR-548f-3p	80.2151	NM_001135811

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Motifs and transcription factors (TFs) regulating SINHCAF

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."