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Center for Computational Systems Medicine
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Gene summary

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Datasets with differential expression of this gene

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Expression of this gene in the resistant group across all datasets and cell types

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Significant ligand-receptor pairs related to this gene (This gene does not contain this module)

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Known drug resistance mechanisms of this gene (This gene does not contain this module)

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MicroRNAs (miRNAs) regulating this gene

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Motifs and transcription factors (TFs) regulating this gene

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Acts as a transcription factor (This gene does not contain this module)

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Acts as a drug target< (This gene does not contain this module)

Gene: SHOC2

Summary for SHOC2

Gene informationGene symbol

SHOC2

Ensembl ID

ENSG00000108061

Entrez ID

8036

Gene nameSHOC2 leucine rich repeat scaffold protein
SynonymsKIAA0862|SOC-2|SOC2|SUR-8|SUR8
Gene typeprotein_coding
UniProtAcc

Q9UQ13


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Dataset with differentially expressed gene: SHOC2

check buttonDifferentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.
DatasetSourceTissueCancer type level1Cancer type level2Drug typeRegimenTimepointCell typeavg_log2FCp_val_adj

GSE186960

Panc1 cell lineCell linePancreatic cancerPancreatic ductal adenocarcinoma (PDAC)ChemotherapygemcitabineNAMalignant cells-0.2714125.54e-09

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpostMalignant cells-0.4204540.00e+00

GSE199333

patientsBone marrow aspirateAcute myeloid leukemiaPrimary FLT3-ITD-mutated acute myeloid leukemia (AML)Targeted therapygilteritinibpreMalignant cells-0.271990.00e+00

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Expression of SHOC2 in the resistant group across all datasets and cell types

check buttonRed dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)
boxplot

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Significant ligand-receptor pairs related to SHOC2

check buttonThis table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

check buttonThis table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SHOC2

check buttonThis table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmiRNAScoreGeneBank accession
SHOC2hsa-miR-5582-3p86.7994NM_001324337
SHOC2hsa-miR-391886.7472NM_001324337
SHOC2hsa-miR-806286.5252NM_001324337
SHOC2hsa-miR-3688-3p86.3281NM_001324337
SHOC2hsa-miR-103b86.2574NM_001324337
SHOC2hsa-miR-449b-5p85.9819NM_007373
SHOC2hsa-miR-34c-5p85.9819NM_007373
SHOC2hsa-miR-216a-5p85.6524NM_001324337
SHOC2hsa-miR-7109-5p85.2926NM_001324337
SHOC2hsa-miR-190b-3p85.0742NM_001324337
SHOC2hsa-miR-145-3p84.9918NM_001324337
SHOC2hsa-miR-3059-5p84.9588NM_007373
SHOC2hsa-let-7f-1-3p84.7636NM_001324337
SHOC2hsa-let-7b-3p84.7636NM_001324337
SHOC2hsa-let-7a-3p84.7636NM_001324337
SHOC2hsa-miR-98-3p84.7636NM_001324337
SHOC2hsa-miR-430284.1364NM_007373
SHOC2hsa-miR-428283.6462NM_007373
SHOC2hsa-miR-500a-5p83.3183NM_007373
SHOC2hsa-miR-608383.2065NM_001324337
SHOC2hsa-miR-4727-5p82.9234NM_007373
SHOC2hsa-miR-4668-5p82.9197NM_001324337
SHOC2hsa-miR-380-3p82.8618NM_001324337
SHOC2hsa-miR-545-3p82.6175NM_007373
SHOC2hsa-miR-4714-5p82.5798NM_001324337
SHOC2hsa-miR-6815-3p82.2482NM_001324337
SHOC2hsa-miR-590-3p82.1574NM_001324337
SHOC2hsa-miR-30e-5p81.6151NM_001324337
SHOC2hsa-miR-30c-5p81.6151NM_001324337
SHOC2hsa-miR-30a-5p81.6151NM_001324337
SHOC2hsa-miR-30d-5p81.6151NM_001324337
SHOC2hsa-miR-30b-5p81.6151NM_001324337
SHOC2hsa-miR-5197-5p80.8175NM_001324337
SHOC2hsa-miR-3189-5p80.5176NM_001324337
SHOC2hsa-miR-493-5p80.3249NM_007373
SHOC2hsa-miR-432880.0212NM_007373
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Motifs and transcription factors (TFs) regulating SHOC2

check buttonThis table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)
Gene symbolmotifTF_highConf
SHOC2metacluster_191.2ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
SHOC2metacluster_191.3EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
SHOC2metacluster_166.4BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
SHOC2taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAPELK3; FOXO1 (directAnnotation).
SHOC2hdpi__TP73TP73 (directAnnotation).
SHOC2metacluster_138.2ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
SHOC2taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_methZNF385D (directAnnotation).
SHOC2hdpi__ETV4ETV4 (directAnnotation).
SHOC2metacluster_33.8BRCA1; CHD2; CHD2; ETS1; NR3C1; ZBED1; ZBED1; ZBED1; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33; ZBTB33 (directAnnotation). CHD2; ZBTB33 (inferredBy_Orthology).
SHOC2taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAPELK1; FOXO1 (directAnnotation).
SHOC2metacluster_141.6MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
SHOC2transfac_pro__M04862NRF1 (directAnnotation).
SHOC2taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_reprE2F1; ELK1 (directAnnotation).
SHOC2taipale_tf_pairs__FOXO1_ETV1_RCCGGAWGTKKN_CAPETV1; FOXO1 (directAnnotation).
SHOC2jaspar__MA0748.2YY2 (directAnnotation).
SHOC2transfac_pro__M01298MECP2 (directAnnotation).
SHOC2metacluster_7.5PLAGL1; PLAGL1 (directAnnotation).
SHOC2taipale_tf_pairs__MYBL1_EOMES_RSGTGNNNAACGK_CAP_reprEOMES; MYBL1 (directAnnotation).
SHOC2metacluster_182.10ZFX (directAnnotation).
SHOC2transfac_pro__M00492STAT1 (directAnnotation).
SHOC2transfac_pro__M06173ZNF85 (directAnnotation).
SHOC2kznf__ZNF571_Imbeault2017_OM_RCADEZNF571 (directAnnotation).
SHOC2metacluster_144.8ZNF30; ZNF30 (directAnnotation).
SHOC2metacluster_141.5NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SHOC2kznf__ZFP57_Imbeault2017_RP_ChIP-seqZFP57 (directAnnotation).
SHOC2metacluster_144.3ZNF704; ZNF704 (directAnnotation).
SHOC2kznf__ZNF100_Imbeault2017_RP_RCADEZNF100 (directAnnotation).
SHOC2jaspar__MA1721.1ZNF93 (directAnnotation).
SHOC2metacluster_151.2ZNF23 (directAnnotation).
SHOC2metacluster_151.1KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SHOC2kznf__ZNF548_Imbeault2017_RP_RCADEZNF548 (directAnnotation).
SHOC2dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1ZBTB8A (directAnnotation).
SHOC2transfac_pro__M01199TRIM28 (directAnnotation).
SHOC2metacluster_133.1ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SHOC2dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1ZSCAN30 (directAnnotation).
SHOC2taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAPETV5; HES7 (directAnnotation).
SHOC2transfac_pro__M01253CNOT3 (directAnnotation).
SHOC2flyfactorsurvey__Mad_FlyReg_FBgn0011648SMAD9 (inferredBy_Orthology).
SHOC2transfac_pro__M02913SP140 (inferredBy_Orthology).
SHOC2dbtfbs__ZNF407_representative_N1ZNF407 (directAnnotation).
SHOC2metacluster_144.5ZNF610; ZNF610; ZNF610 (directAnnotation).
SHOC2taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_reprZBTB37 (directAnnotation).
SHOC2taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_reprE2F8; TFAP2C (directAnnotation).
SHOC2cisbp__M00968MTF2 (directAnnotation).
SHOC2metacluster_160.20JUND; PRDM15 (directAnnotation).
SHOC2metacluster_7.13ZFX (directAnnotation).
SHOC2kznf__ZNF783_Imbeault2017_OM_MEMEZNF783 (directAnnotation).
SHOC2swissregulon__hs__CHD1CHD1 (directAnnotation).
SHOC2idmmpmm__MadSMAD9 (inferredBy_Orthology).
SHOC2homer__NANTGCSGCA_Zfp57ZFP57 (directAnnotation).
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Acts as a transcription factor

check buttonThis table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

check buttonThis table shows that this differential gene acts as a drug target.



1"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."