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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SH3RF1

Summary for SH3RF1

Gene information	Gene symbol	SH3RF1
	Ensembl ID	ENSG00000154447
	Entrez ID	57630
	Gene name	SH3 domain containing ring finger 1
	Synonyms	KIAA1494\|POSH\|RNF142\|SH3MD2
	Gene type	protein_coding
	UniProtAcc	Q7Z6J0

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Dataset with differentially expressed gene: SH3RF1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.493083	0.00e+00

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Expression of SH3RF1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SH3RF1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SH3RF1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SH3RF1	hsa-miR-3681-3p	83.748	NM_020870
SH3RF1	hsa-miR-6818-5p	83.7324	NM_020870
SH3RF1	hsa-let-7d-3p	83.5589	NM_020870
SH3RF1	hsa-miR-4768-3p	83.3488	NM_020870
SH3RF1	hsa-miR-200b-5p	83.2331	NM_020870
SH3RF1	hsa-miR-200a-5p	83.2331	NM_020870
SH3RF1	hsa-miR-4531	82.7094	NM_020870
SH3RF1	hsa-miR-873-5p	81.655	NM_020870
SH3RF1	hsa-miR-4296	81.4852	NM_020870
SH3RF1	hsa-miR-6514-5p	81.1852	NM_020870
SH3RF1	hsa-miR-1843	81.1852	NM_020870
SH3RF1	hsa-miR-4802-5p	81.1852	NM_020870
SH3RF1	hsa-miR-561-5p	80.4848	NM_020870

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Motifs and transcription factors (TFs) regulating SH3RF1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SH3RF1	metacluster_135.11	NR2C2 (directAnnotation).
SH3RF1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SH3RF1	tfdimers__MD00038	TFAP2C (directAnnotation).
SH3RF1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SH3RF1	metacluster_7.13	ZFX (directAnnotation).
SH3RF1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SH3RF1	cisbp__M00968	MTF2 (directAnnotation).
SH3RF1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SH3RF1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SH3RF1	cisbp__M00341	PAX6 (directAnnotation).
SH3RF1	metacluster_198.3	ZFP64 (directAnnotation).
SH3RF1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SH3RF1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SH3RF1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SH3RF1	cisbp__M00788	ZFY (inferredBy_Orthology).
SH3RF1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SH3RF1	hdpi__ZNF304	ZNF304 (directAnnotation).
SH3RF1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SH3RF1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SH3RF1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SH3RF1	transfac_pro__M01199	TRIM28 (directAnnotation).
SH3RF1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SH3RF1	metacluster_151.2	ZNF23 (directAnnotation).
SH3RF1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SH3RF1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SH3RF1	transfac_pro__M03806	ZBTB7C (directAnnotation).
SH3RF1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."