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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SGPP1

Summary for SGPP1

Gene information	Gene symbol	SGPP1
	Ensembl ID	ENSG00000285281
	Entrez ID	81537
	Gene name	sphingosine-1-phosphate phosphatase 1
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9BX95

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Dataset with differentially expressed gene: SGPP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.470931	0.00e+00

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Expression of SGPP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SGPP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SGPP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SGPP1	hsa-miR-3688-3p	87.5906	NM_030791
SGPP1	hsa-miR-3606-3p	87.198	NM_030791
SGPP1	hsa-miR-34c-5p	86.0631	NM_030791
SGPP1	hsa-miR-449b-5p	86.0631	NM_030791
SGPP1	hsa-miR-410-3p	85.6507	NM_030791
SGPP1	hsa-miR-548g-5p	85.459	NM_030791
SGPP1	hsa-miR-548f-5p	85.459	NM_030791
SGPP1	hsa-miR-548aj-5p	85.459	NM_030791
SGPP1	hsa-miR-548x-5p	85.459	NM_030791
SGPP1	hsa-miR-4680-3p	85.0262	NM_030791
SGPP1	hsa-miR-126-5p	84.9047	NM_030791
SGPP1	hsa-miR-548an	84.6765	NM_030791
SGPP1	hsa-miR-2115-3p	84.21	NM_030791
SGPP1	hsa-miR-556-5p	84.0637	NM_030791
SGPP1	hsa-miR-4795-3p	83.7244	NM_030791
SGPP1	hsa-miR-551b-5p	83.5836	NM_030791
SGPP1	hsa-miR-3163	82.8115	NM_030791
SGPP1	hsa-miR-4325	82.6563	NM_030791
SGPP1	hsa-miR-2116-3p	82.4513	NM_030791
SGPP1	hsa-miR-561-3p	81.7343	NM_030791
SGPP1	hsa-miR-379-5p	81.0271	NM_030791
SGPP1	hsa-miR-3529-5p	81.0271	NM_030791
SGPP1	hsa-miR-411-3p	80.6365	NM_030791
SGPP1	hsa-miR-379-3p	80.6365	NM_030791
SGPP1	hsa-miR-4514	80.6145	NM_030791
SGPP1	hsa-miR-4692	80.6145	NM_030791

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Motifs and transcription factors (TFs) regulating SGPP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SGPP1	metacluster_135.11	NR2C2 (directAnnotation).
SGPP1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SGPP1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SGPP1	cisbp__M00968	MTF2 (directAnnotation).
SGPP1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SGPP1	cisbp__M00341	PAX6 (directAnnotation).
SGPP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SGPP1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SGPP1	cisbp__M00788	ZFY (inferredBy_Orthology).
SGPP1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SGPP1	metacluster_175.1	ZNF283 (directAnnotation).
SGPP1	hdpi__ZNF304	ZNF304 (directAnnotation).
SGPP1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SGPP1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SGPP1	transfac_pro__M01199	TRIM28 (directAnnotation).
SGPP1	metacluster_151.2	ZNF23 (directAnnotation).
SGPP1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."