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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SGMS1

Summary for SGMS1

Gene information	Gene symbol	SGMS1
	Ensembl ID	ENSG00000198964
	Entrez ID	259230
	Gene name	sphingomyelin synthase 1
	Synonyms	MGC17342\|MOB\|SMS1\|TMEM23
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SGMS1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.360072	9.17e-24

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Expression of SGMS1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SGMS1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SGMS1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SGMS1	hsa-miR-4753-3p	88.7056	NM_147156
SGMS1	hsa-miR-3180-5p	88.3344	NM_147156
SGMS1	hsa-miR-128-3p	88.3075	NM_147156
SGMS1	hsa-miR-216a-3p	88.3075	NM_147156
SGMS1	hsa-miR-142-5p	87.9114	NM_147156
SGMS1	hsa-miR-5590-3p	87.9114	NM_147156
SGMS1	hsa-miR-4642	86.89	NM_147156
SGMS1	hsa-miR-4531	86.8855	NM_147156
SGMS1	hsa-miR-129-5p	86.2904	NM_147156
SGMS1	hsa-miR-5582-3p	86.1866	NM_147156
SGMS1	hsa-miR-4739	86.0937	NM_147156
SGMS1	hsa-miR-1321	86.0937	NM_147156
SGMS1	hsa-miR-4756-5p	86.0937	NM_147156
SGMS1	hsa-miR-548as-3p	86.0203	NM_147156
SGMS1	hsa-miR-5692a	85.8666	NM_147156
SGMS1	hsa-miR-6128	85.8369	NM_147156
SGMS1	hsa-miR-3680-3p	85.58	NM_147156
SGMS1	hsa-miR-450b-5p	85.58	NM_147156
SGMS1	hsa-miR-32-3p	85.3667	NM_147156
SGMS1	hsa-miR-506-3p	84.837	NM_147156
SGMS1	hsa-miR-124-3p	84.837	NM_147156
SGMS1	hsa-miR-1468-3p	84.8002	NM_147156
SGMS1	hsa-miR-6799-5p	84.7355	NM_147156
SGMS1	hsa-miR-6817-3p	84.7323	NM_147156
SGMS1	hsa-miR-1250-3p	84.7123	NM_147156
SGMS1	hsa-miR-6826-5p	84.6047	NM_147156
SGMS1	hsa-miR-3065-5p	84.375	NM_147156
SGMS1	hsa-miR-3681-3p	84.192	NM_147156
SGMS1	hsa-miR-154-5p	83.6229	NM_147156
SGMS1	hsa-miR-889-5p	83.3709	NM_147156
SGMS1	hsa-miR-12120	83.3585	NM_147156
SGMS1	hsa-miR-519c-3p	83.3406	NM_147156
SGMS1	hsa-miR-519a-3p	83.3406	NM_147156
SGMS1	hsa-miR-519b-3p	83.3406	NM_147156
SGMS1	hsa-miR-301b-5p	83.0517	NM_147156
SGMS1	hsa-miR-301a-5p	83.0517	NM_147156
SGMS1	hsa-miR-6869-5p	82.7614	NM_147156
SGMS1	hsa-miR-5701	82.6051	NM_147156
SGMS1	hsa-miR-217-3p	81.6471	NM_147156
SGMS1	hsa-miR-620	81.5187	NM_147156
SGMS1	hsa-miR-1270	81.5187	NM_147156
SGMS1	hsa-miR-376b-3p	81.4171	NM_147156
SGMS1	hsa-miR-376a-3p	81.4171	NM_147156
SGMS1	hsa-miR-548at-5p	81.2603	NM_147156
SGMS1	hsa-miR-182-5p	81.2257	NM_147156
SGMS1	hsa-miR-12136	81.0241	NM_147156
SGMS1	hsa-miR-12131	80.9655	NM_147156
SGMS1	hsa-miR-29a-5p	80.8967	NM_147156
SGMS1	hsa-miR-5011-5p	80.6007	NM_147156
SGMS1	hsa-miR-1227-5p	80.5327	NM_147156

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Motifs and transcription factors (TFs) regulating SGMS1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SGMS1	metacluster_135.11	NR2C2 (directAnnotation).
SGMS1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
SGMS1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
SGMS1	metacluster_7.13	ZFX (directAnnotation).
SGMS1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
SGMS1	cisbp__M00968	MTF2 (directAnnotation).
SGMS1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
SGMS1	metacluster_160.20	JUND; PRDM15 (directAnnotation).
SGMS1	cisbp__M00341	PAX6 (directAnnotation).
SGMS1	metacluster_198.3	ZFP64 (directAnnotation).
SGMS1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SGMS1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SGMS1	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
SGMS1	cisbp__M00788	ZFY (inferredBy_Orthology).
SGMS1	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SGMS1	metacluster_175.1	ZNF283 (directAnnotation).
SGMS1	hdpi__ZNF304	ZNF304 (directAnnotation).
SGMS1	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SGMS1	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SGMS1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SGMS1	transfac_pro__M01199	TRIM28 (directAnnotation).
SGMS1	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SGMS1	metacluster_151.2	ZNF23 (directAnnotation).
SGMS1	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
SGMS1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
SGMS1	transfac_pro__M03806	ZBTB7C (directAnnotation).
SGMS1	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."