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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEMA3A

Summary for SEMA3A

Gene information	Gene symbol	SEMA3A
	Ensembl ID	ENSG00000075213
	Entrez ID	10371
	Gene name	semaphorin 3A
	Synonyms	coll-1\|Hsema-I\|SEMA1\|SEMAD\|SemD
	Gene type	protein_coding
	UniProtAcc	Q14563

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Dataset with differentially expressed gene: SEMA3A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	3.24183	5.35e-07

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Expression of SEMA3A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEMA3A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEMA3A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEMA3A	hsa-miR-629-3p	90.1029	NM_006080
SEMA3A	hsa-miR-150-5p	90.0768	NM_006080
SEMA3A	hsa-miR-424-5p	89.8355	NM_006080
SEMA3A	hsa-miR-223-5p	89.8251	NM_006080
SEMA3A	hsa-miR-586	89.3973	NM_006080
SEMA3A	hsa-miR-6807-3p	89.3153	NM_006080
SEMA3A	hsa-miR-497-5p	89.2277	NM_006080
SEMA3A	hsa-miR-4709-3p	89.1118	NM_006080
SEMA3A	hsa-miR-222-5p	89.0098	NM_006080
SEMA3A	hsa-miR-12119	88.4594	NM_006080
SEMA3A	hsa-miR-320b	88.4015	NM_006080
SEMA3A	hsa-miR-4429	88.4015	NM_006080
SEMA3A	hsa-miR-320c	88.4015	NM_006080
SEMA3A	hsa-miR-320d	88.4015	NM_006080
SEMA3A	hsa-miR-320a-3p	88.4015	NM_006080
SEMA3A	hsa-miR-130a-5p	88.3268	NM_006080
SEMA3A	hsa-miR-5581-3p	88.1589	NM_006080
SEMA3A	hsa-miR-3617-5p	87.7109	NM_006080
SEMA3A	hsa-miR-641	87.7109	NM_006080
SEMA3A	hsa-miR-3692-3p	87.4024	NM_006080
SEMA3A	hsa-miR-3605-5p	87.1239	NM_006080
SEMA3A	hsa-miR-4680-3p	86.976	NM_006080
SEMA3A	hsa-miR-196b-5p	86.8238	NM_006080
SEMA3A	hsa-miR-6831-5p	86.8238	NM_006080
SEMA3A	hsa-miR-196a-5p	86.8238	NM_006080
SEMA3A	hsa-miR-5684	86.7264	NM_006080
SEMA3A	hsa-miR-3927-3p	86.5538	NM_006080
SEMA3A	hsa-miR-6083	86.4344	NM_006080
SEMA3A	hsa-miR-494-3p	86.2362	NM_006080
SEMA3A	hsa-miR-4760-5p	85.5732	NM_006080
SEMA3A	hsa-miR-3163	85.46	NM_006080
SEMA3A	hsa-miR-511-3p	85.2491	NM_006080
SEMA3A	hsa-miR-25-3p	85.014	NM_006080
SEMA3A	hsa-miR-367-3p	85.014	NM_006080
SEMA3A	hsa-miR-363-3p	85.014	NM_006080
SEMA3A	hsa-miR-372-5p	84.6211	NM_006080
SEMA3A	hsa-miR-4307	84.3356	NM_006080
SEMA3A	hsa-miR-203a-3p	84.1183	NM_006080
SEMA3A	hsa-miR-6833-3p	84.0001	NM_006080
SEMA3A	hsa-miR-30e-5p	82.6059	NM_006080
SEMA3A	hsa-miR-30d-5p	82.6059	NM_006080
SEMA3A	hsa-miR-30a-5p	82.6059	NM_006080
SEMA3A	hsa-miR-30b-5p	82.6059	NM_006080
SEMA3A	hsa-miR-30c-5p	82.6059	NM_006080
SEMA3A	hsa-miR-4775	82.2012	NM_006080
SEMA3A	hsa-miR-4424	82.1417	NM_006080
SEMA3A	hsa-miR-499a-5p	82.1147	NM_006080
SEMA3A	hsa-miR-3925-3p	82.0631	NM_006080
SEMA3A	hsa-miR-936	81.8778	NM_006080
SEMA3A	hsa-miR-33a-5p	81.7745	NM_006080

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Motifs and transcription factors (TFs) regulating SEMA3A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEMA3A	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."