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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SEL1L

Summary for SEL1L

Gene information	Gene symbol	SEL1L
	Ensembl ID	ENSG00000071537
	Entrez ID	6400
	Gene name	SEL1L adaptor subunit of ERAD E3 ubiquitin ligase
	Synonyms	Hrd3\|IBD2\|SEL1L1
	Gene type	protein_coding
	UniProtAcc	Q9UBV2

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Dataset with differentially expressed gene: SEL1L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	0.79578	0.00e+00
GSE161195	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	DARA-KRD (daratumumab + carfilzomib + lenalidomide + dexamethasone)	pre	Malignant cells	-0.289275	0.00e+00
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.302637	8.02e-30
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.412824	1.26e-41

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Expression of SEL1L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SEL1L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SEL1L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SEL1L	hsa-miR-6832-3p	89.1198	NM_005065
SEL1L	hsa-miR-19b-1-5p	88.6765	NM_005065
SEL1L	hsa-miR-19b-2-5p	88.6765	NM_005065
SEL1L	hsa-miR-548p	88.2594	NM_001244984
SEL1L	hsa-miR-6868-3p	87.7617	NM_005065
SEL1L	hsa-miR-7156-3p	87.3866	NM_005065
SEL1L	hsa-miR-5692a	87.2987	NM_005065
SEL1L	hsa-miR-4684-3p	87.2825	NM_001244984
SEL1L	hsa-miR-4460	87.0225	NM_005065
SEL1L	hsa-miR-6781-3p	86.5623	NM_005065
SEL1L	hsa-miR-4420	86.4507	NM_005065
SEL1L	hsa-miR-4482-3p	86.3591	NM_005065
SEL1L	hsa-miR-19b-3p	86.223	NM_005065
SEL1L	hsa-miR-19a-3p	86.223	NM_005065
SEL1L	hsa-miR-3919	86.0976	NM_001244984
SEL1L	hsa-miR-6719-3p	85.5221	NM_005065
SEL1L	hsa-miR-183-5p	85.5137	NM_005065
SEL1L	hsa-miR-6792-5p	85.4409	NM_005065
SEL1L	hsa-miR-19a-5p	85.0603	NM_005065
SEL1L	hsa-miR-2682-3p	84.498	NM_005065
SEL1L	hsa-miR-584-3p	84.4962	NM_005065
SEL1L	hsa-miR-12136	84.4876	NM_005065
SEL1L	hsa-miR-4682	84.3315	NM_005065
SEL1L	hsa-miR-6783-3p	84.2789	NM_005065
SEL1L	hsa-miR-330-3p	84.2391	NM_005065
SEL1L	hsa-miR-668-3p	84.1626	NM_005065
SEL1L	hsa-miR-6817-3p	83.709	NM_001244984
SEL1L	hsa-miR-3679-5p	83.604	NM_005065
SEL1L	hsa-miR-551b-5p	83.5396	NM_005065
SEL1L	hsa-miR-147a	83.213	NM_005065
SEL1L	hsa-miR-335-3p	82.8926	NM_005065
SEL1L	hsa-miR-141-5p	82.873	NM_001244984
SEL1L	hsa-miR-135a-3p	82.3664	NM_001244984
SEL1L	hsa-miR-3690	81.2124	NM_005065
SEL1L	hsa-miR-1343-3p	81.184	NM_005065
SEL1L	hsa-miR-4433a-3p	81.0086	NM_005065
SEL1L	hsa-miR-4728-3p	80.9692	NM_005065
SEL1L	hsa-miR-3064-3p	80.9691	NM_005065
SEL1L	hsa-miR-5680	80.8465	NM_005065
SEL1L	hsa-miR-29a-5p	80.794	NM_005065
SEL1L	hsa-miR-181a-2-3p	80.7533	NM_005065
SEL1L	hsa-miR-4666a-5p	80.7289	NM_001244984
SEL1L	hsa-miR-3168	80.7204	NM_005065
SEL1L	hsa-miR-2115-3p	80.5794	NM_005065
SEL1L	hsa-miR-651-3p	80.1841	NM_005065
SEL1L	hsa-miR-525-5p	80.107	NM_005065
SEL1L	hsa-miR-520a-5p	80.107	NM_005065
SEL1L	hsa-miR-10527-5p	80.0742	NM_005065

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Motifs and transcription factors (TFs) regulating SEL1L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SEL1L	taipale_tf_pairs__ATF4_TEF_RNMTGATGCAATN_CAP	ATF4; TEF (directAnnotation).
SEL1L	taipale_tf_pairs__ATF4_CEBPD_NGATGATGCAATNN_CAP	ATF4; CEBPD (directAnnotation).
SEL1L	metacluster_174.3	MBD2; NFYA; NFYB; NFYC; PBX3 (directAnnotation).
SEL1L	metacluster_156.2	ATF3; ATF4; ATF4; ATF4; ATF4; ATF4; ATF4; CEBPG; CEBPG; DDIT3; MYC (directAnnotation). ATF4; ATF4; ATF4; CEBPG; DDIT3 (inferredBy_Orthology).
SEL1L	metacluster_174.2	CEBPZ; CEBPZ; DRAP1; FOS; FOXI1; FOXI1; HMGXB3; IRF3; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYA; NFYB; NFYB; NFYB; NFYB; NFYB; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; NFYC; PBX3; PBX3; SP2 (directAnnotation). NFYA; NFYA; NFYC; PBX1; PBX3 (inferredBy_Orthology).
SEL1L	taipale_tf_pairs__ATF4_CEBPB_NNATGAYGCAAYN_CAP	ATF4; CEBPB (directAnnotation).
SEL1L	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
SEL1L	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
SEL1L	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
SEL1L	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
SEL1L	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
SEL1L	hdpi__ZNF304	ZNF304 (directAnnotation).
SEL1L	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
SEL1L	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
SEL1L	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
SEL1L	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
SEL1L	jaspar__MA0502.2	NFYB (directAnnotation).
SEL1L	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
SEL1L	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
SEL1L	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
SEL1L	transfac_pro__M06111	ZNF254 (directAnnotation).
SEL1L	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."