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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: SDC3

Summary for SDC3

Gene information	Gene symbol	SDC3
	Ensembl ID	ENSG00000162512
	Entrez ID	9672
	Gene name	syndecan 3
	Synonyms	N-syndecan\|SYND3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: SDC3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.456807	1.59e-07
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.288692	6.12e-16
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.42683	4.64e-36
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.407964	5.38e-22
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.562834	0.00e+00

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Expression of SDC3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to SDC3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating SDC3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
SDC3	hsa-miR-4269	86.1231	NM_014654
SDC3	hsa-let-7a-2-3p	86.0924	NM_014654
SDC3	hsa-let-7g-3p	86.0924	NM_014654
SDC3	hsa-miR-486-3p	85.9331	NM_014654
SDC3	hsa-miR-6883-5p	85.4715	NM_014654
SDC3	hsa-miR-149-3p	85.4715	NM_014654
SDC3	hsa-miR-4270	85.3733	NM_014654
SDC3	hsa-miR-6754-5p	85.3644	NM_014654
SDC3	hsa-miR-505-5p	85.0016	NM_014654
SDC3	hsa-miR-6887-3p	83.5306	NM_014654
SDC3	hsa-miR-4731-5p	83.362	NM_014654
SDC3	hsa-miR-6852-5p	83.2847	NM_014654
SDC3	hsa-miR-4755-3p	82.8115	NM_014654
SDC3	hsa-miR-4323	82.2687	NM_014654
SDC3	hsa-miR-6735-5p	81.8101	NM_014654
SDC3	hsa-miR-6879-5p	81.8101	NM_014654
SDC3	hsa-miR-4768-3p	81.7083	NM_014654
SDC3	hsa-miR-3664-3p	81.53	NM_014654
SDC3	hsa-miR-6748-5p	81.4718	NM_014654
SDC3	hsa-miR-6892-3p	81.2456	NM_014654
SDC3	hsa-miR-874-5p	81.153	NM_014654
SDC3	hsa-miR-510-5p	80.935	NM_014654
SDC3	hsa-miR-7151-3p	80.8437	NM_014654
SDC3	hsa-miR-6842-3p	80.433	NM_014654
SDC3	hsa-miR-30c-1-3p	80.046	NM_014654
SDC3	hsa-miR-30c-2-3p	80.046	NM_014654
SDC3	hsa-miR-6788-5p	80.046	NM_014654
SDC3	hsa-miR-1249-5p	80.0429	NM_014654
SDC3	hsa-miR-6797-5p	80.0429	NM_014654

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Motifs and transcription factors (TFs) regulating SDC3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
SDC3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
SDC3	transfac_pro__M05770	ZNF77 (directAnnotation).
SDC3	transfac_pro__M07260	IKZF1 (directAnnotation).
SDC3	metacluster_29.2	BCL6; IRF3; IRF3; STAT1; STAT1; STAT1; STAT2; STAT3; STAT3; STAT3; STAT4; STAT4; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT5B; STAT6 (directAnnotation). STAT3; STAT5A; STAT5A; STAT5A; STAT5A; STAT5A; STAT5B; STAT5B; STAT6; STAT6 (inferredBy_Orthology).
SDC3	hdpi__TFAM	TFAM (directAnnotation).
SDC3	transfac_pro__M06219	ZNF266 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."