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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RUNX2

Summary for RUNX2

Gene information	Gene symbol	RUNX2
	Ensembl ID	ENSG00000124813
	Entrez ID	860
	Gene name	RUNX family transcription factor 2
	Synonyms	AML3\|CBFA1\|CCD\|CCD1\|PEBP2A1\|PEBP2aA1
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RUNX2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.3219	0.00e+00

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Expression of RUNX2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RUNX2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RUNX2	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RUNX2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RUNX2	hsa-miR-8054	86.9417	NM_001015051
RUNX2	hsa-miR-548av-5p	86.9417	NM_001015051
RUNX2	hsa-miR-548k	86.9417	NM_001015051
RUNX2	hsa-miR-3119	86.9127	NM_001015051
RUNX2	hsa-miR-6728-3p	86.9019	NM_001015051
RUNX2	hsa-miR-4656	86.8343	NM_001015051
RUNX2	hsa-miR-146a-3p	86.5736	NM_001015051
RUNX2	hsa-miR-3121-3p	86.5354	NM_001015051
RUNX2	hsa-miR-194-3p	86.4193	NM_001015051
RUNX2	hsa-miR-218-5p	86.4062	NM_001015051
RUNX2	hsa-miR-6817-3p	86.3585	NM_001015051
RUNX2	hsa-miR-6882-3p	85.8191	NM_001015051
RUNX2	hsa-miR-4703-5p	85.5434	NM_001015051
RUNX2	hsa-miR-6828-3p	85.5339	NM_001015051
RUNX2	hsa-miR-584-5p	85.2788	NM_001015051
RUNX2	hsa-miR-2681-5p	85.2012	NM_001015051
RUNX2	hsa-miR-6857-3p	84.8212	NM_001015051
RUNX2	hsa-miR-3154	84.7351	NM_001015051
RUNX2	hsa-miR-4776-3p	84.7205	NM_001015051
RUNX2	hsa-miR-19b-2-5p	84.6108	NM_001015051
RUNX2	hsa-miR-19b-1-5p	84.6108	NM_001015051
RUNX2	hsa-miR-19a-5p	84.6108	NM_001015051
RUNX2	hsa-miR-3941	84.582	NM_001015051
RUNX2	hsa-miR-6807-3p	84.2277	NM_001015051
RUNX2	hsa-miR-302a-3p	84.2266	NM_001015051
RUNX2	hsa-miR-302c-3p	84.2266	NM_001015051
RUNX2	hsa-miR-302b-3p	84.2266	NM_001015051
RUNX2	hsa-miR-302d-3p	84.2266	NM_001015051
RUNX2	hsa-miR-520e-3p	84.0198	NM_001015051
RUNX2	hsa-miR-3942-5p	83.167	NM_001015051
RUNX2	hsa-miR-4691-3p	83.1024	NM_001015051
RUNX2	hsa-miR-129-1-3p	83.0983	NM_001015051
RUNX2	hsa-miR-129-2-3p	83.0983	NM_001015051
RUNX2	hsa-miR-4659b-5p	82.9887	NM_001015051
RUNX2	hsa-miR-1825	82.6793	NM_001015051
RUNX2	hsa-miR-1283	82.6063	NM_001015051
RUNX2	hsa-miR-152-3p	82.0666	NM_001015051
RUNX2	hsa-miR-148a-3p	82.0666	NM_001015051
RUNX2	hsa-miR-148b-3p	82.0666	NM_001015051
RUNX2	hsa-miR-373-3p	81.9786	NM_001015051
RUNX2	hsa-miR-607	81.6548	NM_001015051
RUNX2	hsa-miR-6868-3p	81.586	NM_001015051
RUNX2	hsa-miR-12123	81.3182	NM_001015051
RUNX2	hsa-miR-520c-3p	81.2989	NM_001015051
RUNX2	hsa-miR-520a-3p	81.2989	NM_001015051
RUNX2	hsa-miR-520b-3p	81.2989	NM_001015051
RUNX2	hsa-miR-372-3p	81.2989	NM_001015051
RUNX2	hsa-miR-520d-3p	81.2989	NM_001015051
RUNX2	hsa-miR-5000-5p	81.1344	NM_001015051
RUNX2	hsa-miR-153-3p	81.0055	NM_001015051

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Motifs and transcription factors (TFs) regulating RUNX2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RUNX2	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RUNX2	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RUNX2	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RUNX2	transfac_pro__M04950	EGR1 (directAnnotation).
RUNX2	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RUNX2	transfac_pro__M04826	EP300 (directAnnotation).
RUNX2	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RUNX2	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RUNX2	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RUNX2	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
RUNX2	metacluster_197.2	E2F4; E2F7; E2F7; E2F7; E2F8; E2F8 (directAnnotation).
RUNX2	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RUNX2	cisbp__M08198	ELF1 (directAnnotation).
RUNX2	transfac_pro__M00652	NRF1 (directAnnotation).
RUNX2	hdpi__ETV4	ETV4 (directAnnotation).
RUNX2	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RUNX2	transfac_pro__M04866	HDAC2 (directAnnotation).
RUNX2	jaspar__MA1122.1	TFDP1 (directAnnotation).
RUNX2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RUNX2	metacluster_34.1	ZNF143; ZNF143; ZNF143; ZNF76; ZNF76; ZNF76 (directAnnotation).
RUNX2	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RUNX2	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RUNX2	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."