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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RREB1

Summary for RREB1

Gene information	Gene symbol	RREB1
	Ensembl ID	ENSG00000124782
	Entrez ID	6239
	Gene name	ras responsive element binding protein 1
	Synonyms	HNT
	Gene type	protein_coding
	UniProtAcc	Q92766

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Dataset with differentially expressed gene: RREB1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.259693	0.00e+00

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Expression of RREB1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RREB1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RREB1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RREB1	hsa-miR-196a-1-3p	87.03	NM_001003698
RREB1	hsa-miR-424-5p	86.781	NM_001003698
RREB1	hsa-miR-497-5p	86.781	NM_001003698
RREB1	hsa-miR-9-3p	86.6532	NM_001003698
RREB1	hsa-miR-6838-5p	86.3227	NM_001003698
RREB1	hsa-miR-500a-3p	86.1396	NM_001003698
RREB1	hsa-miR-8070	85.032	NM_001003698
RREB1	hsa-miR-10393-5p	84.1401	NM_001003698
RREB1	hsa-miR-4319	83.5013	NM_001003698
RREB1	hsa-miR-124-3p	83.3275	NM_001003698
RREB1	hsa-miR-506-3p	83.3275	NM_001003698
RREB1	hsa-miR-31-5p	82.8423	NM_001003698
RREB1	hsa-miR-17-3p	81.9792	NM_001003698
RREB1	hsa-miR-1284	81.74	NM_001003698
RREB1	hsa-miR-125b-5p	81.6243	NM_001003698
RREB1	hsa-miR-125a-5p	81.6243	NM_001003698
RREB1	hsa-miR-3191-5p	81.5873	NM_001003698
RREB1	hsa-miR-4755-5p	81.2712	NM_001003698
RREB1	hsa-miR-5006-3p	81.2712	NM_001003698
RREB1	hsa-miR-514b-5p	81.1087	NM_001003698
RREB1	hsa-miR-513c-5p	81.1087	NM_001003698
RREB1	hsa-miR-3059-5p	80.7048	NM_001003698
RREB1	hsa-miR-4760-3p	80.6535	NM_001003698

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Motifs and transcription factors (TFs) regulating RREB1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RREB1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RREB1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RREB1	cisbp__M00249	WT1 (directAnnotation).
RREB1	transfac_pro__M01122	ZNF219 (directAnnotation).
RREB1	metacluster_151.2	ZNF23 (directAnnotation).
RREB1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RREB1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RREB1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
RREB1	metacluster_7.13	ZFX (directAnnotation).
RREB1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RREB1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RREB1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RREB1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
RREB1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RREB1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
RREB1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RREB1	taipale_tf_pairs__GCM1_ERG_RTRYGGGCGGAARKN_CAP	ERG; GCM1 (directAnnotation).
RREB1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RREB1	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RREB1	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RREB1	transfac_pro__M01253	CNOT3 (directAnnotation).
RREB1	metacluster_3.10	KLF2; KLF4 (directAnnotation).
RREB1	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RREB1	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RREB1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RREB1	transfac_pro__M05479	ZNF580 (directAnnotation).
RREB1	jaspar__MA1122.1	TFDP1 (directAnnotation).
RREB1	cisbp__M00341	PAX6 (directAnnotation).
RREB1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RREB1	transfac_pro__M01199	TRIM28 (directAnnotation).
RREB1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RREB1	tfdimers__MD00151	CHURC1 (directAnnotation).
RREB1	tfdimers__MD00391	KLF4 (directAnnotation).
RREB1	taipale_tf_pairs__GCM1_ETV1_RTRNNGGCGGAAGTN_CAP	ETV1; GCM1 (directAnnotation).
RREB1	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
RREB1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RREB1	cisbp__M00968	MTF2 (directAnnotation).
RREB1	transfac_pro__M01973	PLAG1 (directAnnotation).
RREB1	transfac_pro__M12697	ZNF142 (directAnnotation).
RREB1	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RREB1	transfac_pro__M01303	SP1 (directAnnotation).
RREB1	metacluster_3.14	WT1; WT1 (directAnnotation).
RREB1	transfac_public__M00491	PATZ1 (directAnnotation).
RREB1	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RREB1	transfac_pro__M07397	ZNF148 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."