Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RPS6KA3

Summary for RPS6KA3

Gene information	Gene symbol	RPS6KA3
	Ensembl ID	ENSG00000177189
	Entrez ID	6197
	Gene name	ribosomal protein S6 kinase A3
	Synonyms	CLS\|HU-3\|MRX19\|RSK2
	Gene type	protein_coding
	UniProtAcc	P51812

Top

Dataset with differentially expressed gene: RPS6KA3

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.286557	2.18e-10
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.293644	7.54e-14

Top

Expression of RPS6KA3 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to RPS6KA3

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RPS6KA3	Unusual Activation of Pro-survival Pathway

Page: 1

Top

MicroRNAs (miRNA) regulating RPS6KA3

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPS6KA3	hsa-miR-892c-3p	86.6809	NM_004586
RPS6KA3	hsa-miR-4676-3p	86.6809	NM_004586
RPS6KA3	hsa-miR-452-5p	86.6809	NM_004586
RPS6KA3	hsa-miR-4477b	86.1947	NM_004586
RPS6KA3	hsa-miR-6504-3p	86.0303	NM_004586
RPS6KA3	hsa-miR-302e	85.9807	NM_004586
RPS6KA3	hsa-miR-6824-5p	85.4693	NM_004586
RPS6KA3	hsa-miR-466	85.2793	NM_004586
RPS6KA3	hsa-miR-1468-3p	85.2791	NM_004586
RPS6KA3	hsa-miR-548l	85.0606	NM_004586
RPS6KA3	hsa-miR-548ac	85.0402	NM_004586
RPS6KA3	hsa-miR-548bb-3p	85.0402	NM_004586
RPS6KA3	hsa-miR-548z	85.0402	NM_004586
RPS6KA3	hsa-miR-548h-3p	85.0402	NM_004586
RPS6KA3	hsa-miR-548d-3p	85.0402	NM_004586
RPS6KA3	hsa-miR-429	84.7727	NM_004586
RPS6KA3	hsa-miR-200c-3p	84.7727	NM_004586
RPS6KA3	hsa-miR-200b-3p	84.7727	NM_004586
RPS6KA3	hsa-miR-204-5p	84.5914	NM_004586
RPS6KA3	hsa-miR-211-5p	84.5914	NM_004586
RPS6KA3	hsa-miR-520d-5p	84.4664	NM_004586
RPS6KA3	hsa-miR-524-5p	84.4664	NM_004586
RPS6KA3	hsa-miR-4804-3p	84.2956	NM_004586
RPS6KA3	hsa-miR-4762-3p	84.042	NM_004586
RPS6KA3	hsa-miR-7844-5p	83.9297	NM_004586
RPS6KA3	hsa-miR-541-5p	83.8181	NM_004586
RPS6KA3	hsa-miR-548t-5p	83.6418	NM_004586
RPS6KA3	hsa-miR-548az-5p	83.6418	NM_004586
RPS6KA3	hsa-miR-4684-5p	83.4165	NM_004586
RPS6KA3	hsa-miR-635	83.1604	NM_004586
RPS6KA3	hsa-miR-6774-5p	83.1604	NM_004586
RPS6KA3	hsa-miR-6868-3p	83.033	NM_004586
RPS6KA3	hsa-miR-3190-5p	82.6437	NM_004586
RPS6KA3	hsa-miR-302b-3p	82.2517	NM_004586
RPS6KA3	hsa-miR-302a-3p	82.2517	NM_004586
RPS6KA3	hsa-miR-302c-3p	82.2517	NM_004586
RPS6KA3	hsa-miR-302d-3p	82.2517	NM_004586
RPS6KA3	hsa-miR-4667-3p	82.0617	NM_004586
RPS6KA3	hsa-miR-577	81.8673	NM_004586
RPS6KA3	hsa-miR-410-3p	81.7429	NM_004586
RPS6KA3	hsa-miR-520a-3p	81.6694	NM_004586
RPS6KA3	hsa-miR-373-3p	81.6694	NM_004586
RPS6KA3	hsa-miR-520e-3p	81.6694	NM_004586
RPS6KA3	hsa-miR-520d-3p	81.6694	NM_004586
RPS6KA3	hsa-miR-520b-3p	81.6694	NM_004586
RPS6KA3	hsa-miR-520c-3p	81.6694	NM_004586
RPS6KA3	hsa-miR-372-3p	81.6694	NM_004586
RPS6KA3	hsa-miR-205-5p	81.2384	NM_004586
RPS6KA3	hsa-miR-4724-3p	81.1804	NM_004586
RPS6KA3	hsa-miR-6758-5p	80.8629	NM_004586

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating RPS6KA3

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPS6KA3	metacluster_135.11	NR2C2 (directAnnotation).
RPS6KA3	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RPS6KA3	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RPS6KA3	metacluster_7.13	ZFX (directAnnotation).
RPS6KA3	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RPS6KA3	cisbp__M00968	MTF2 (directAnnotation).
RPS6KA3	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RPS6KA3	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RPS6KA3	cisbp__M00341	PAX6 (directAnnotation).
RPS6KA3	metacluster_198.3	ZFP64 (directAnnotation).
RPS6KA3	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RPS6KA3	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RPS6KA3	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RPS6KA3	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RPS6KA3	cisbp__M00788	ZFY (inferredBy_Orthology).
RPS6KA3	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RPS6KA3	metacluster_175.1	ZNF283 (directAnnotation).
RPS6KA3	hdpi__ZNF304	ZNF304 (directAnnotation).
RPS6KA3	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RPS6KA3	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RPS6KA3	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RPS6KA3	transfac_pro__M01199	TRIM28 (directAnnotation).
RPS6KA3	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RPS6KA3	metacluster_151.2	ZNF23 (directAnnotation).
RPS6KA3	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RPS6KA3	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RPS6KA3	transfac_pro__M03806	ZBTB7C (directAnnotation).
RPS6KA3	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RPS6KA3	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RPS6KA3	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RPS6KA3	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RPS6KA3	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RPS6KA3	transfac_pro__M04826	EP300 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RPS6KA3	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RPS6KA3	taipale_tf_pairs__ELF2_NATGCGGAAGTR_HT	ELF2 (directAnnotation).
RPS6KA3	jaspar__MA1708.1	ETV7 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
RPS6KA3	hdpi__TP73	TP73 (directAnnotation).
RPS6KA3	hdpi__ELF2	ELF2 (directAnnotation).
RPS6KA3	taipale_tf_pairs__FOXO1_ELK1_TGTTGCCGGANNN_CAP	ELK1; FOXO1 (directAnnotation).
RPS6KA3	taipale_tf_pairs__ETV5_EOMES_TNRCACCGGAWN_CAP	EOMES; ETV5 (directAnnotation).
RPS6KA3	metacluster_183.4	ETS1 (inferredBy_Orthology).
RPS6KA3	metacluster_81.7	CREB1 (directAnnotation).
RPS6KA3	transfac_pro__M01298	MECP2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RPS6KA3	"Acetylsalicylic acid"	DB00945	small molecule
RPS6KA3	"Fostamatinib"	DB12010	small molecule

Page: 1

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."