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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RPRD1A

Summary for RPRD1A

Gene information	Gene symbol	RPRD1A
	Ensembl ID	ENSG00000141425
	Entrez ID	55197
	Gene name	regulation of nuclear pre-mRNA domain containing 1A
	Synonyms	FLJ10656\|HsT3101\|P15RS
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RPRD1A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.339656	0.00e+00

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Expression of RPRD1A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RPRD1A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RPRD1A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RPRD1A	hsa-miR-10b-5p	86.3797	NM_001303411
RPRD1A	hsa-miR-10a-5p	86.3797	NM_001303411
RPRD1A	hsa-miR-4457	86.3763	NM_001303411
RPRD1A	hsa-miR-3065-5p	85.9409	NM_001303413
RPRD1A	hsa-miR-1183	85.8691	NM_001303412
RPRD1A	hsa-miR-1253	85.8077	NM_001303411
RPRD1A	hsa-miR-8485	85.761	NM_001303411
RPRD1A	hsa-miR-3529-3p	85.5192	NM_001303413
RPRD1A	hsa-miR-494-3p	85.2141	NM_001303411
RPRD1A	hsa-miR-4711-3p	84.9723	NM_001303413
RPRD1A	hsa-miR-3143	84.5797	NM_001303413
RPRD1A	hsa-miR-548j-3p	84.5406	NM_001303411
RPRD1A	hsa-miR-548ah-3p	84.5406	NM_001303411
RPRD1A	hsa-miR-548ae-3p	84.5406	NM_001303411
RPRD1A	hsa-miR-548aq-3p	84.5406	NM_001303411
RPRD1A	hsa-miR-548am-3p	84.5406	NM_001303411
RPRD1A	hsa-miR-4694-3p	84.349	NM_001303411
RPRD1A	hsa-miR-4766-5p	84.2669	NM_001303412
RPRD1A	hsa-miR-4677-3p	84.2476	NM_001303411
RPRD1A	hsa-miR-154-3p	84.1578	NM_001303411
RPRD1A	hsa-miR-487a-3p	84.1578	NM_001303411
RPRD1A	hsa-miR-4511	84.0587	NM_001303411
RPRD1A	hsa-miR-5692b	83.8333	NM_001303413
RPRD1A	hsa-miR-5692c	83.8333	NM_001303413
RPRD1A	hsa-miR-6808-3p	83.0757	NM_001303413
RPRD1A	hsa-miR-4760-3p	82.7477	NM_001303412
RPRD1A	hsa-miR-6852-3p	82.6069	NM_001303411
RPRD1A	hsa-miR-6715a-3p	82.3623	NM_001303411
RPRD1A	hsa-miR-8062	82.3064	NM_001303411
RPRD1A	hsa-miR-6081	82.1105	NM_001303413
RPRD1A	hsa-miR-4531	81.8073	NM_001303411
RPRD1A	hsa-miR-196a-1-3p	81.7215	NM_001303413
RPRD1A	hsa-miR-9898	81.5405	NM_001303411
RPRD1A	hsa-miR-6856-3p	81.2776	NM_001303412
RPRD1A	hsa-miR-374a-5p	80.7483	NM_001303413
RPRD1A	hsa-miR-7847-3p	80.2614	NM_001303411
RPRD1A	hsa-miR-3922-5p	80.2494	NM_001303411
RPRD1A	hsa-miR-4749-3p	80.155	NM_001303411

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Motifs and transcription factors (TFs) regulating RPRD1A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RPRD1A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RPRD1A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RPRD1A	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
RPRD1A	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
RPRD1A	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RPRD1A	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
RPRD1A	metacluster_7.13	ZFX (directAnnotation).
RPRD1A	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RPRD1A	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
RPRD1A	transfac_pro__M01175	ZBTB7B (directAnnotation).
RPRD1A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RPRD1A	tfdimers__MD00151	CHURC1 (directAnnotation).
RPRD1A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RPRD1A	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
RPRD1A	transfac_pro__M01303	SP1 (directAnnotation).
RPRD1A	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RPRD1A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RPRD1A	transfac_pro__M02090	E2F4 (directAnnotation).
RPRD1A	transfac_pro__M01714	KLF15 (directAnnotation).
RPRD1A	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
RPRD1A	metacluster_3.14	WT1; WT1 (directAnnotation).
RPRD1A	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RPRD1A	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
RPRD1A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RPRD1A	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RPRD1A	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RPRD1A	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RPRD1A	transfac_pro__M02898	SMAD3 (directAnnotation).
RPRD1A	transfac_public__M00491	PATZ1 (directAnnotation).
RPRD1A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."