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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: ROR1

Summary for ROR1

Gene information	Gene symbol	ROR1
	Ensembl ID	ENSG00000185483
	Entrez ID	4919
	Gene name	receptor tyrosine kinase like orphan receptor 1
	Synonyms	NTRKR1
	Gene type	protein_coding
	UniProtAcc	Q01973

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Dataset with differentially expressed gene: ROR1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	-1.37519	1.08e-02

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Expression of ROR1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to ROR1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating ROR1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
ROR1	hsa-miR-365a-3p	90.4207	NM_005012
ROR1	hsa-miR-365b-3p	90.4207	NM_005012
ROR1	hsa-miR-505-3p	89.7468	NM_005012
ROR1	hsa-miR-548bb-3p	89.5923	NM_005012
ROR1	hsa-miR-548z	89.5923	NM_005012
ROR1	hsa-miR-548ac	89.5923	NM_005012
ROR1	hsa-miR-548h-3p	89.5923	NM_005012
ROR1	hsa-miR-548d-3p	89.5923	NM_005012
ROR1	hsa-miR-548aw	88.7762	NM_005012
ROR1	hsa-miR-107	87.9474	NM_005012
ROR1	hsa-miR-103a-3p	87.9474	NM_005012
ROR1	hsa-miR-6824-3p	87.7327	NM_005012
ROR1	hsa-miR-6764-3p	87.7327	NM_005012
ROR1	hsa-miR-5692a	86.8973	NM_005012
ROR1	hsa-miR-4445-5p	86.8244	NM_005012
ROR1	hsa-miR-153-3p	86.6237	NM_005012
ROR1	hsa-miR-508-3p	86.1756	NM_005012
ROR1	hsa-miR-149-5p	85.9552	NM_005012
ROR1	hsa-miR-4668-5p	85.9146	NM_005012
ROR1	hsa-miR-520d-5p	85.8864	NM_005012
ROR1	hsa-miR-524-5p	85.8864	NM_005012
ROR1	hsa-miR-4307	85.7557	NM_005012
ROR1	hsa-miR-3184-3p	85.5578	NM_005012
ROR1	hsa-miR-3910	84.7734	NM_001083592
ROR1	hsa-miR-6881-3p	84.5878	NM_005012
ROR1	hsa-miR-4446-5p	84.4358	NM_005012
ROR1	hsa-miR-1252-3p	84.4034	NM_005012
ROR1	hsa-miR-889-3p	84.1602	NM_005012
ROR1	hsa-miR-450a-1-3p	83.9495	NM_005012
ROR1	hsa-miR-7849-3p	83.6982	NM_005012
ROR1	hsa-miR-5089-5p	83.4394	NM_001083592
ROR1	hsa-miR-653-3p	83.2375	NM_005012
ROR1	hsa-miR-4677-5p	83.0313	NM_005012
ROR1	hsa-miR-513a-5p	82.0079	NM_005012
ROR1	hsa-miR-8068	81.5382	NM_005012
ROR1	hsa-miR-17-3p	81.4226	NM_001083592
ROR1	hsa-miR-548c-3p	81.1652	NM_005012
ROR1	hsa-miR-627-3p	80.9014	NM_005012
ROR1	hsa-miR-448	80.8881	NM_005012
ROR1	hsa-miR-190a-3p	80.6964	NM_005012

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Motifs and transcription factors (TFs) regulating ROR1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."