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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF38

Summary for RNF38

Gene information	Gene symbol	RNF38
	Ensembl ID	ENSG00000137075
	Entrez ID	152006
	Gene name	ring finger protein 38
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q9H0F5

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Dataset with differentially expressed gene: RNF38

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mast cells	-0.485427	4.62e-02

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Expression of RNF38 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF38

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF38

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF38	hsa-miR-3671	92.5163	NM_022781
RNF38	hsa-miR-133a-5p	92.4829	NM_022781
RNF38	hsa-miR-3942-3p	91.6308	NM_194332
RNF38	hsa-miR-6785-5p	91.6285	NM_022781
RNF38	hsa-miR-216a-3p	91.5301	NM_022781
RNF38	hsa-miR-128-3p	91.5301	NM_022781
RNF38	hsa-miR-3923	91.51	NM_194332
RNF38	hsa-miR-3613-3p	91.323	NM_022781
RNF38	hsa-miR-5589-3p	91.2028	NM_022781
RNF38	hsa-miR-95-5p	91.0353	NM_194332
RNF38	hsa-miR-6753-5p	90.7302	NM_194332
RNF38	hsa-miR-208b-5p	90.1834	NM_194332
RNF38	hsa-miR-208a-5p	90.1834	NM_194332
RNF38	hsa-miR-3614-3p	90.1164	NM_194332
RNF38	hsa-miR-651-3p	89.8841	NM_194332
RNF38	hsa-miR-4728-5p	89.7211	NM_022781
RNF38	hsa-miR-3681-3p	89.4242	NM_022781
RNF38	hsa-miR-6716-5p	89.2163	NM_022781
RNF38	hsa-miR-4517	89.0711	NM_194332
RNF38	hsa-miR-2113	89.0126	NM_022781
RNF38	hsa-miR-504-5p	88.6284	NM_022781
RNF38	hsa-miR-4725-5p	88.6284	NM_022781
RNF38	hsa-miR-548e-5p	88.4691	NM_022781
RNF38	hsa-miR-377-3p	88.3605	NM_194332
RNF38	hsa-miR-147b-5p	88.2095	NM_022781
RNF38	hsa-miR-7114-3p	88.1501	NM_194332
RNF38	hsa-miR-3142	87.8478	NM_022781
RNF38	hsa-miR-1245b-5p	87.8478	NM_022781
RNF38	hsa-miR-7703	87.3088	NM_022781
RNF38	hsa-miR-4325	87.3088	NM_022781
RNF38	hsa-miR-6883-5p	86.9343	NM_022781
RNF38	hsa-miR-149-3p	86.9343	NM_022781
RNF38	hsa-miR-4261	86.8813	NM_022781
RNF38	hsa-miR-671-5p	86.8757	NM_022781
RNF38	hsa-miR-7853-5p	86.8575	NM_022781
RNF38	hsa-miR-105-5p	86.8575	NM_022781
RNF38	hsa-miR-4456	86.6057	NM_194332
RNF38	hsa-miR-329-3p	86.4196	NM_194332
RNF38	hsa-miR-362-3p	86.4196	NM_194332
RNF38	hsa-let-7g-3p	86.2515	NM_022781
RNF38	hsa-let-7a-2-3p	86.2515	NM_022781
RNF38	hsa-miR-545-3p	86.0907	NM_194332
RNF38	hsa-miR-512-3p	86.03	NM_194332
RNF38	hsa-miR-4266	85.7489	NM_194332
RNF38	hsa-miR-7157-5p	85.4712	NM_022781
RNF38	hsa-miR-4310	85.4712	NM_022781
RNF38	hsa-miR-4475	85.1848	NM_022781
RNF38	hsa-miR-1180-5p	85.0025	NM_194332
RNF38	hsa-miR-4302	84.6981	NM_022781
RNF38	hsa-miR-519d-5p	84.6367	NM_194332

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Motifs and transcription factors (TFs) regulating RNF38

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF38	taipale_tf_pairs__ETV2_EOMES_NGGTGTNNNNNNNNNNNNNNNCCGGAWNNN_CAP_repr	EOMES; ETV2 (directAnnotation).
RNF38	taipale_tf_pairs__ELK1_EOMES_RGGTGNGANNNNNNNNTNNCACCGGAAGY_CAP	ELK1; EOMES (directAnnotation).
RNF38	metacluster_113.4	MYB; MYB; MYBL1; MYBL2 (directAnnotation). MYB; MYB; MYBL1; MYBL2 (inferredBy_Orthology).
RNF38	swissregulon__hs__MYB	MYB (directAnnotation).
RNF38	transfac_pro__M04944	GABPA (directAnnotation).
RNF38	transfac_pro__M05655	ZNF705G (directAnnotation).
RNF38	nitta__sens_TATGCT40NACT_KAA_AATAAATCACTGCA_m1_c3	GFI1 (inferredBy_Orthology).
RNF38	transfac_pro__M06383	ZNF629 (inferredBy_Orthology).
RNF38	transfac_pro__M07474	TBX20 (directAnnotation).
RNF38	metacluster_155.21	ZNF454; ZNF454 (directAnnotation).
RNF38	transfac_pro__M06332	ZNF585A (directAnnotation).
RNF38	transfac_pro__M06905	ZNF585B (directAnnotation).
RNF38	transfac_pro__M05883	ZNF709 (directAnnotation).
RNF38	transfac_pro__M05690	ZNF20 (directAnnotation).
RNF38	transfac_pro__M06340	ZNF790 (directAnnotation).
RNF38	transfac_pro__M05617	ZNF500 (directAnnotation).
RNF38	transfac_pro__M06745	ZNF780B (directAnnotation).
RNF38	metacluster_126.11	ZNF286A (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."