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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RNF217

Summary for RNF217

Gene information	Gene symbol	RNF217
	Ensembl ID	ENSG00000146373
	Entrez ID	154214
	Gene name	ring finger protein 217
	Synonyms	C6orf172\|dJ84N20.1\|IBRDC1\|MGC26996
	Gene type	protein_coding
	UniProtAcc	Q8TC41

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Dataset with differentially expressed gene: RNF217

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	0.31824	3.21e-14

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Expression of RNF217 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RNF217

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RNF217

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RNF217	hsa-miR-4307	87.1233	NM_001286398
RNF217	hsa-miR-578	87.1112	NM_152553
RNF217	hsa-miR-4775	87.0739	NM_152553
RNF217	hsa-miR-335-3p	86.6934	NM_152553
RNF217	hsa-miR-374c-5p	86.6928	NM_001286398
RNF217	hsa-miR-6507-5p	86.6225	NM_152553
RNF217	hsa-miR-8068	86.6218	NM_001286398
RNF217	hsa-miR-32-3p	86.6197	NM_152553
RNF217	hsa-miR-4427	86.5424	NM_001286398
RNF217	hsa-miR-9-3p	86.2964	NM_001286398
RNF217	hsa-miR-520d-5p	85.9289	NM_001286398
RNF217	hsa-miR-7850-5p	85.4782	NM_001286398
RNF217	hsa-miR-8061	84.9026	NM_001286398
RNF217	hsa-miR-559	84.7065	NM_001286398
RNF217	hsa-miR-655-3p	84.5092	NM_001286398
RNF217	hsa-miR-548j-3p	84.3201	NM_001286398
RNF217	hsa-miR-548ae-3p	84.3201	NM_001286398
RNF217	hsa-miR-548aq-3p	84.3201	NM_001286398
RNF217	hsa-miR-4504	84.3105	NM_001286398
RNF217	hsa-miR-5692a	84.0998	NM_152553
RNF217	hsa-miR-450b-5p	84.0356	NM_001286398
RNF217	hsa-miR-526b-5p	83.9428	NM_152553
RNF217	hsa-miR-524-5p	83.0324	NM_001286398
RNF217	hsa-miR-4796-3p	82.944	NM_152553
RNF217	hsa-miR-1277-5p	82.8047	NM_001286398
RNF217	hsa-miR-6730-3p	82.7581	NM_001286398
RNF217	hsa-miR-5579-3p	82.4511	NM_001286398
RNF217	hsa-miR-4760-5p	82.3555	NM_001286398
RNF217	hsa-miR-582-3p	82.1998	NM_001286398
RNF217	hsa-miR-548ar-3p	82.1909	NM_001286398
RNF217	hsa-miR-8070	81.8205	NM_152553
RNF217	hsa-miR-4457	81.806	NM_001286398
RNF217	hsa-miR-340-5p	81.7785	NM_152553
RNF217	hsa-miR-889-3p	81.6589	NM_001286398
RNF217	hsa-miR-3613-3p	81.6207	NM_001286398
RNF217	hsa-miR-194-5p	81.3477	NM_001286398
RNF217	hsa-miR-548am-3p	81.2953	NM_001286398
RNF217	hsa-miR-548ah-3p	81.2953	NM_001286398
RNF217	hsa-miR-5582-3p	81.1864	NM_001286398
RNF217	hsa-miR-548ak	81.1762	NM_001286398
RNF217	hsa-miR-548c-5p	81.1762	NM_001286398
RNF217	hsa-miR-548i	81.1762	NM_001286398
RNF217	hsa-miR-548a-5p	81.1762	NM_001286398
RNF217	hsa-miR-548ab	81.1762	NM_001286398
RNF217	hsa-miR-548b-5p	81.1762	NM_001286398
RNF217	hsa-miR-548o-5p	81.1762	NM_001286398
RNF217	hsa-miR-548bb-5p	81.1762	NM_001286398
RNF217	hsa-miR-548j-5p	81.1762	NM_001286398
RNF217	hsa-miR-548au-5p	81.1762	NM_001286398
RNF217	hsa-miR-548ar-5p	81.1762	NM_001286398

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Motifs and transcription factors (TFs) regulating RNF217

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RNF217	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RNF217	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RNF217	transfac_pro__M00652	NRF1 (directAnnotation).
RNF217	transfac_pro__M04918	EGR1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."