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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RMND5A

Summary for RMND5A

Gene information	Gene symbol	RMND5A
	Ensembl ID	ENSG00000153561
	Entrez ID	64795
	Gene name	required for meiotic nuclear division 5 homolog A
	Synonyms	FLJ13910\|GID2\|GID2A\|p44CTLH\|RMD5
	Gene type	protein_coding
	UniProtAcc	Q9H871

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Dataset with differentially expressed gene: RMND5A

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.686201	3.45e-03

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Expression of RMND5A in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RMND5A

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RMND5A

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RMND5A	hsa-miR-651-3p	93.3914	NM_022780
RMND5A	hsa-miR-20a-3p	92.9237	NM_022780
RMND5A	hsa-miR-5011-5p	92.7937	NM_022780
RMND5A	hsa-miR-561-3p	92.7004	NM_022780
RMND5A	hsa-miR-335-3p	92.516	NM_022780
RMND5A	hsa-miR-579-3p	92.1774	NM_022780
RMND5A	hsa-miR-5087	92.1475	NM_022780
RMND5A	hsa-miR-6715b-5p	91.9559	NM_022780
RMND5A	hsa-miR-4269	91.9559	NM_022780
RMND5A	hsa-miR-302a-5p	91.7404	NM_022780
RMND5A	hsa-miR-558	91.5444	NM_022780
RMND5A	hsa-miR-7978	91.4902	NM_022780
RMND5A	hsa-miR-122b-5p	91.346	NM_022780
RMND5A	hsa-miR-6768-5p	91.2339	NM_022780
RMND5A	hsa-miR-6781-3p	90.8414	NM_022780
RMND5A	hsa-miR-6134	90.4227	NM_022780
RMND5A	hsa-miR-664b-3p	90.3182	NM_022780
RMND5A	hsa-miR-3646	89.8204	NM_022780
RMND5A	hsa-miR-1468-3p	89.5337	NM_022780
RMND5A	hsa-miR-7705	89.1253	NM_022780
RMND5A	hsa-miR-6847-5p	88.9718	NM_022780
RMND5A	hsa-miR-188-3p	88.8428	NM_022780
RMND5A	hsa-miR-21-5p	88.5484	NM_022780
RMND5A	hsa-miR-4775	88.2946	NM_022780
RMND5A	hsa-miR-3160-5p	88.0734	NM_022780
RMND5A	hsa-miR-513b-5p	87.9069	NM_022780
RMND5A	hsa-miR-1910-5p	87.8897	NM_022780
RMND5A	hsa-miR-548aw	87.7979	NM_022780
RMND5A	hsa-miR-5579-3p	87.7484	NM_022780
RMND5A	hsa-miR-548at-5p	87.6945	NM_022780
RMND5A	hsa-miR-2115-3p	87.3614	NM_022780
RMND5A	hsa-miR-383-5p	86.9921	NM_022780
RMND5A	hsa-miR-4774-3p	86.7803	NM_022780
RMND5A	hsa-miR-302d-5p	86.6901	NM_022780
RMND5A	hsa-miR-302b-5p	86.6901	NM_022780
RMND5A	hsa-miR-4328	86.6118	NM_022780
RMND5A	hsa-miR-4319	86.5299	NM_022780
RMND5A	hsa-miR-4709-5p	85.9326	NM_022780
RMND5A	hsa-miR-2682-3p	85.8885	NM_022780
RMND5A	hsa-miR-548n	85.7993	NM_022780
RMND5A	hsa-miR-153-5p	85.704	NM_022780
RMND5A	hsa-miR-6853-3p	85.4201	NM_022780
RMND5A	hsa-miR-3135b	85.3464	NM_022780
RMND5A	hsa-miR-548v	85.2693	NM_022780
RMND5A	hsa-miR-3152-5p	85.1641	NM_022780
RMND5A	hsa-miR-527	84.6242	NM_022780
RMND5A	hsa-miR-518a-5p	84.6242	NM_022780
RMND5A	hsa-miR-590-5p	84.3539	NM_022780
RMND5A	hsa-miR-4692	83.2579	NM_022780
RMND5A	hsa-miR-4742-5p	83.2579	NM_022780

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Motifs and transcription factors (TFs) regulating RMND5A

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RMND5A	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RMND5A	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RMND5A	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RMND5A	transfac_pro__M04617	ZBTB7A (directAnnotation).
RMND5A	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RMND5A	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RMND5A	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RMND5A	transfac_pro__M07387	ZBTB7A (directAnnotation).
RMND5A	transfac_pro__M07436	WT1 (directAnnotation).
RMND5A	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RMND5A	transfac_pro__M00716	ZBTB14 (directAnnotation).
RMND5A	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RMND5A	hdpi__HIP2	UBE2K (directAnnotation).
RMND5A	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RMND5A	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RMND5A	transfac_pro__M04893	TAF1 (directAnnotation).
RMND5A	transfac_pro__M03876	ZBTB33 (directAnnotation).
RMND5A	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RMND5A	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RMND5A	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RMND5A	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RMND5A	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."