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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RICTOR

Summary for RICTOR

Gene information	Gene symbol	RICTOR
	Ensembl ID	ENSG00000164327
	Entrez ID	253260
	Gene name	RPTOR independent companion of MTOR complex 2
	Synonyms	AVO3\|KIAA1999\|MGC39830\|PIA
	Gene type	protein_coding
	UniProtAcc	Q6R327

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Dataset with differentially expressed gene: RICTOR

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	1.08744	3.54e-09
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	Mono/Macro	0.496513	3.18e-23
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.308315	7.49e-28
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.527458	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.368483	6.10e-35
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.541535	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.383503	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Erythrocytes	0.335198	1.48e-06
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.365208	1.53e-36

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Expression of RICTOR in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RICTOR

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RICTOR	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RICTOR

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RICTOR	hsa-miR-4255	92.5548	NM_001285439
RICTOR	hsa-miR-802	92.3609	NM_001285439
RICTOR	hsa-miR-2113	92.2992	NM_001285439
RICTOR	hsa-miR-338-5p	92.2573	NM_001285439
RICTOR	hsa-miR-6867-5p	92.1434	NM_001285439
RICTOR	hsa-miR-628-3p	92.1426	NM_001285440
RICTOR	hsa-miR-203a-3p	91.9811	NM_001285439
RICTOR	hsa-miR-4282	91.9239	NM_001285440
RICTOR	hsa-miR-7157-3p	91.6229	NM_001285439
RICTOR	hsa-miR-6737-3p	91.6229	NM_001285439
RICTOR	hsa-miR-153-3p	91.4714	NM_001285439
RICTOR	hsa-miR-551b-5p	91.4265	NM_001285440
RICTOR	hsa-miR-5190	91.421	NM_001285440
RICTOR	hsa-miR-495-3p	91.1121	NM_001285439
RICTOR	hsa-miR-7162-3p	90.5296	NM_001285439
RICTOR	hsa-miR-513c-3p	90.3867	NM_001285440
RICTOR	hsa-miR-513a-3p	90.3867	NM_001285440
RICTOR	hsa-miR-155-5p	90.2986	NM_001285439
RICTOR	hsa-miR-7152-5p	89.9812	NM_001285440
RICTOR	hsa-miR-3163	89.9599	NM_001285439
RICTOR	hsa-miR-324-3p	89.8317	NM_001285439
RICTOR	hsa-miR-4307	89.6836	NM_001285440
RICTOR	hsa-miR-137-3p	89.6588	NM_001285439
RICTOR	hsa-miR-5008-3p	89.6062	NM_001285439
RICTOR	hsa-miR-4649-3p	89.5867	NM_001285439
RICTOR	hsa-miR-1277-5p	89.5158	NM_001285440
RICTOR	hsa-miR-3692-3p	89.446	NM_001285440
RICTOR	hsa-miR-1323	89.1529	NM_001285440
RICTOR	hsa-miR-1255b-2-3p	88.8932	NM_001285440
RICTOR	hsa-miR-489-3p	88.8667	NM_001285440
RICTOR	hsa-miR-4329	88.7443	NM_001285440
RICTOR	hsa-miR-6832-3p	88.5529	NM_001285439
RICTOR	hsa-miR-148b-3p	88.5048	NM_001285439
RICTOR	hsa-miR-148a-3p	88.5048	NM_001285439
RICTOR	hsa-miR-152-3p	88.5048	NM_001285439
RICTOR	hsa-miR-3910	88.42	NM_001285439
RICTOR	hsa-miR-140-3p	88.228	NM_001285439
RICTOR	hsa-miR-548g-5p	88.1185	NM_001285439
RICTOR	hsa-miR-548aj-5p	88.1185	NM_001285439
RICTOR	hsa-miR-548x-5p	88.1185	NM_001285439
RICTOR	hsa-miR-186-3p	88.0653	NM_001285440
RICTOR	hsa-miR-584-3p	87.9324	NM_001285439
RICTOR	hsa-miR-466	87.9298	NM_001285439
RICTOR	hsa-miR-3606-3p	87.8965	NM_001285440
RICTOR	hsa-miR-365b-3p	87.6512	NM_001285440
RICTOR	hsa-miR-365a-3p	87.6512	NM_001285440
RICTOR	hsa-miR-2467-5p	87.4712	NM_001285439
RICTOR	hsa-miR-548t-3p	87.3219	NM_001285439
RICTOR	hsa-miR-548aa	87.3219	NM_001285439
RICTOR	hsa-miR-548ap-3p	87.3219	NM_001285439

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Motifs and transcription factors (TFs) regulating RICTOR

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RICTOR	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RICTOR	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RICTOR	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RICTOR	transfac_pro__M04617	ZBTB7A (directAnnotation).
RICTOR	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RICTOR	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RICTOR	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RICTOR	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RICTOR	transfac_pro__M07387	ZBTB7A (directAnnotation).
RICTOR	transfac_pro__M07436	WT1 (directAnnotation).
RICTOR	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RICTOR	transfac_pro__M00716	ZBTB14 (directAnnotation).
RICTOR	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RICTOR	hdpi__HIP2	UBE2K (directAnnotation).
RICTOR	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RICTOR	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RICTOR	transfac_pro__M04893	TAF1 (directAnnotation).
RICTOR	transfac_pro__M03876	ZBTB33 (directAnnotation).
RICTOR	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RICTOR	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RICTOR	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RICTOR	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RICTOR	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RICTOR	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
RICTOR	dbtfbs__ZBTB8A_HEK293_ENCSR481FEC_merged_N1	ZBTB8A (directAnnotation).
RICTOR	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RICTOR	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
RICTOR	transfac_pro__M12686	ZBTB10 (directAnnotation).
RICTOR	metacluster_143.14	ZNF320 (directAnnotation).
RICTOR	kznf__ZNF383_Imbeault2017_RP_RCADE	ZNF383 (directAnnotation).
RICTOR	dbtfbs__ZBTB10_HEK293_ENCSR004PLU_merged_N1	ZBTB10 (directAnnotation).
RICTOR	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RICTOR	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
RICTOR	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
RICTOR	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RICTOR	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
RICTOR	kznf__ZNF141_Imbeault2017_RP_RCADE	ZNF141 (directAnnotation).
RICTOR	transfac_pro__M01973	PLAG1 (directAnnotation).
RICTOR	metacluster_151.2	ZNF23 (directAnnotation).
RICTOR	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RICTOR	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
RICTOR	metacluster_66.1	MTF1; ZNF320; ZNF320; ZNF320; ZNF782 (directAnnotation).
RICTOR	cisbp__M01864	EGR1 (inferredBy_Orthology).
RICTOR	tfdimers__MD00391	KLF4 (directAnnotation).
RICTOR	kznf__ZNF267_Imbeault2017_RP_RCADE	ZNF267 (directAnnotation).
RICTOR	tfdimers__MD00151	CHURC1 (directAnnotation).
RICTOR	transfac_pro__M04817	ZBTB33 (directAnnotation).
RICTOR	cisbp__M00139	ZNF281 (inferredBy_Orthology).
RICTOR	taipale_tf_pairs__TFAP2C_HES7_NNCRCGYGNNNNNNNSCCNNNGGS_CAP_repr	HES7; TFAP2C (directAnnotation).
RICTOR	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."