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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RGL1

Summary for RGL1

Gene information	Gene symbol	RGL1
	Ensembl ID	ENSG00000143344
	Entrez ID	23179
	Gene name	ral guanine nucleotide dissociation stimulator like 1
	Synonyms	RGL
	Gene type	protein_coding
	UniProtAcc	Q9NZL6

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Dataset with differentially expressed gene: RGL1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Mono/Macro	0.375642	3.54e-06

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Expression of RGL1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RGL1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RGL1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RGL1	hsa-miR-891a-3p	87.5214	NM_001297669
RGL1	hsa-miR-20a-3p	87.448	NM_001297669
RGL1	hsa-miR-4534	85.9351	NM_001297669
RGL1	hsa-miR-641	85.8002	NM_001297669
RGL1	hsa-miR-3617-5p	85.8002	NM_001297669
RGL1	hsa-miR-302d-5p	85.3589	NM_001297669
RGL1	hsa-miR-302b-5p	85.3589	NM_001297669
RGL1	hsa-miR-4456	85.1818	NM_001297669
RGL1	hsa-miR-339-5p	85.1318	NM_001297669
RGL1	hsa-miR-548f-5p	83.7474	NM_001297669
RGL1	hsa-miR-4474-5p	83.616	NM_001297669
RGL1	hsa-miR-8082	83.3155	NM_001297669
RGL1	hsa-miR-211-5p	83.2032	NM_001297669
RGL1	hsa-miR-204-5p	83.2032	NM_001297669
RGL1	hsa-miR-127-5p	82.8945	NM_001297669
RGL1	hsa-miR-587	82.7287	NM_001297669
RGL1	hsa-miR-146b-3p	82.5808	NM_001297669
RGL1	hsa-miR-4307	82.109	NM_001297669
RGL1	hsa-miR-429	82.1008	NM_001297669
RGL1	hsa-miR-200b-3p	82.1008	NM_001297669
RGL1	hsa-miR-200c-3p	82.1008	NM_001297669
RGL1	hsa-miR-2467-3p	81.9511	NM_001297669
RGL1	hsa-miR-1972	80.3797	NM_001297669

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Motifs and transcription factors (TFs) regulating RGL1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RGL1	jaspar__MA1939.1	SREBF2 (directAnnotation).
RGL1	metacluster_119.2	CCNT2; GATA1; GATA1; GATA1; GATA1; GATA2; GATA2; GATA2; NCOA1; TAL1; TAL1; TAL1; TAL1; ZNF823 (directAnnotation). GATA1; TAL1; TAL1; TAL1; TAL1 (inferredBy_Orthology).
RGL1	hdpi__TFAM	TFAM (directAnnotation).
RGL1	transfac_pro__M06072	ZNF623 (directAnnotation).
RGL1	kznf__ZBTB12_Schmitges2016_RCADE	ZBTB12 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."