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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: REV3L

Summary for REV3L

Gene information	Gene symbol	REV3L
	Ensembl ID	ENSG00000009413
	Entrez ID	5980
	Gene name	REV3 like, DNA directed polymerase zeta catalytic subunit
	Synonyms	POLZ\|REV3
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: REV3L

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.258553	7.90e-15
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.25421	3.41e-09

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Expression of REV3L in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to REV3L

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
REV3L	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating REV3L

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
REV3L	hsa-miR-1324	90.2597	NM_001286431
REV3L	hsa-miR-6516-5p	90.1649	NM_001286432
REV3L	hsa-miR-4789-3p	88.9806	NM_001286432
REV3L	hsa-miR-4643	88.0119	NM_001286432
REV3L	hsa-miR-548ax	87.7708	NM_001286431
REV3L	hsa-miR-548ao-5p	87.7708	NM_001286431
REV3L	hsa-miR-8063	87.4762	NM_001286431
REV3L	hsa-miR-4282	87.1745	NM_001286432
REV3L	hsa-miR-4796-3p	86.3777	NM_001286432
REV3L	hsa-miR-106b-5p	86.3777	NM_001286432
REV3L	hsa-miR-20a-5p	86.3777	NM_001286432
REV3L	hsa-miR-33a-3p	85.9901	NM_001286432
REV3L	hsa-miR-12123	85.8632	NM_001286431
REV3L	hsa-miR-507	85.7438	NM_001286432
REV3L	hsa-miR-4796-5p	85.4369	NM_001286432
REV3L	hsa-miR-4470	85.3331	NM_001286432
REV3L	hsa-miR-3189-5p	85.1691	NM_001286432
REV3L	hsa-miR-93-5p	85.0602	NM_001286432
REV3L	hsa-miR-526b-3p	85.0602	NM_001286432
REV3L	hsa-miR-17-5p	85.0602	NM_001286432
REV3L	hsa-miR-106a-5p	85.0602	NM_001286432
REV3L	hsa-miR-519d-3p	85.0602	NM_001286432
REV3L	hsa-miR-20b-5p	85.0602	NM_001286432
REV3L	hsa-miR-3163	84.4099	NM_001286432
REV3L	hsa-miR-5680	83.9203	NM_001286431
REV3L	hsa-miR-561-5p	83.7147	NM_001286431
REV3L	hsa-miR-5087	83.7089	NM_001286432
REV3L	hsa-miR-7856-5p	83.3906	NM_001286432
REV3L	hsa-miR-937-5p	81.666	NM_001286432
REV3L	hsa-miR-568	81.4189	NM_001286432
REV3L	hsa-miR-557	81.3227	NM_001286432
REV3L	hsa-miR-4799-5p	81.1854	NM_001286432
REV3L	hsa-miR-548p	81.0963	NM_001286431
REV3L	hsa-miR-5010-3p	80.4992	NM_001286432
REV3L	hsa-miR-194-5p	80.382	NM_001286431
REV3L	hsa-miR-3180-5p	80.0318	NM_001286432

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Motifs and transcription factors (TFs) regulating REV3L

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
REV3L	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
REV3L	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
REV3L	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
REV3L	metacluster_7.13	ZFX (directAnnotation).
REV3L	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
REV3L	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
REV3L	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
REV3L	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
REV3L	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
REV3L	cisbp__M00249	WT1 (directAnnotation).
REV3L	cisbp__M01863	ZNF711 (inferredBy_Orthology).
REV3L	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
REV3L	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
REV3L	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
REV3L	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
REV3L	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
REV3L	cisbp__M00775	ZBTB1 (inferredBy_Orthology).
REV3L	transfac_pro__M00514	ATF4 (directAnnotation).
REV3L	metacluster_126.2	ZBTB4; ZBTB4 (directAnnotation).
REV3L	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
REV3L	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
REV3L	metacluster_3.10	KLF2; KLF4 (directAnnotation).
REV3L	transfac_pro__M07436	WT1 (directAnnotation).
REV3L	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
REV3L	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
REV3L	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
REV3L	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
REV3L	transfac_pro__M02089	E2F3 (directAnnotation).
REV3L	metacluster_3.14	WT1; WT1 (directAnnotation).
REV3L	transfac_pro__M04817	ZBTB33 (directAnnotation).
REV3L	metacluster_19.9	AHR; AHR; SREBF1; SREBF1; SREBF2; SREBF2 (directAnnotation). SREBF1 (inferredBy_Orthology).
REV3L	cisbp__M00968	MTF2 (directAnnotation).
REV3L	taipale_cyt_meth__GCM1_RTGCGGGTN_eDBD	GCM1 (directAnnotation).
REV3L	jaspar__MA1650.1	ZBTB14 (directAnnotation).
REV3L	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
REV3L	cisbp__M00809	PRDM11 (inferredBy_Orthology).
REV3L	hdpi__NRL	NRL (directAnnotation).
REV3L	transfac_pro__M02898	SMAD3 (directAnnotation).
REV3L	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
REV3L	transfac_pro__M07310	SP5 (directAnnotation).
REV3L	transfac_pro__M00322	MAX; MYC (directAnnotation).
REV3L	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
REV3L	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
REV3L	transfac_pro__M01122	ZNF219 (directAnnotation).
REV3L	dbtfbs__HIC1_HEK293_ENCSR803GYT_merged_N1	HIC1 (directAnnotation).
REV3L	metacluster_23.9	GLIS1; GLIS3; GLIS3; ZNF575 (directAnnotation). GLIS2; GLIS2; GLIS3; ZNF575; ZXDA; ZXDA; ZXDA; ZXDA; ZXDB; ZXDB; ZXDB; ZXDB; ZXDC; ZXDC; ZXDC; ZXDC (inferredBy_Orthology).
REV3L	kznf__EGR2_Barrera2016.1_PBM	EGR2 (directAnnotation).
REV3L	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."