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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: REST

Summary for REST

Gene information	Gene symbol	REST
	Ensembl ID	ENSG00000084093
	Entrez ID	5978
	Gene name	RE1 silencing transcription factor
	Synonyms	DFNA27\|NRSF\|XBR
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: REST

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.391711	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.285479	6.89e-15
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.324362	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.353582	1.98e-33

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Expression of REST in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to REST

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating REST

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
REST	hsa-miR-3065-5p	90.256	NM_001193508
REST	hsa-miR-4531	89.5366	NM_001193508
REST	hsa-miR-4495	89.3284	NM_001193508
REST	hsa-miR-942-3p	88.8969	NM_001193508
REST	hsa-miR-302c-5p	88.456	NM_001193508
REST	hsa-miR-548a-3p	88.3829	NM_001193508
REST	hsa-miR-548az-3p	88.1866	NM_001193508
REST	hsa-miR-548bc	88.1866	NM_001193508
REST	hsa-miR-548f-3p	88.1866	NM_001193508
REST	hsa-miR-548e-3p	88.1866	NM_001193508
REST	hsa-miR-548ar-3p	88.0083	NM_001193508
REST	hsa-miR-3662	87.9651	NM_001193508
REST	hsa-miR-302e	87.413	NM_001193508
REST	hsa-miR-8063	87.3036	NM_001193508
REST	hsa-miR-330-3p	86.3498	NM_001193508
REST	hsa-miR-302a-3p	86.2131	NM_001193508
REST	hsa-miR-373-3p	86.2131	NM_001193508
REST	hsa-miR-520d-3p	86.2131	NM_001193508
REST	hsa-miR-372-3p	86.2131	NM_001193508
REST	hsa-miR-302d-3p	86.2131	NM_001193508
REST	hsa-miR-520b-3p	86.2131	NM_001193508
REST	hsa-miR-520a-3p	86.2131	NM_001193508
REST	hsa-miR-520e-3p	86.2131	NM_001193508
REST	hsa-miR-302b-3p	86.2131	NM_001193508
REST	hsa-miR-302c-3p	86.2131	NM_001193508
REST	hsa-miR-520c-3p	86.2131	NM_001193508
REST	hsa-miR-4753-3p	86.1805	NM_001193508
REST	hsa-miR-1269b	85.9221	NM_001193508
REST	hsa-miR-1269a	85.9221	NM_001193508
REST	hsa-miR-4282	85.7889	NM_001193508
REST	hsa-miR-651-5p	85.3975	NM_001193508
REST	hsa-miR-340-5p	85.1076	NM_001193508
REST	hsa-miR-142-5p	84.9932	NM_001193508
REST	hsa-miR-5590-3p	84.9932	NM_001193508
REST	hsa-miR-676-5p	84.5892	NM_001193508
REST	hsa-miR-7703	83.7355	NM_001193508
REST	hsa-miR-4325	83.7355	NM_001193508
REST	hsa-miR-5087	83.5668	NM_001193508
REST	hsa-miR-9-5p	82.7073	NM_001193508
REST	hsa-miR-19a-3p	82.4387	NM_001193508
REST	hsa-miR-19b-3p	82.4387	NM_001193508
REST	hsa-miR-217-5p	82.3588	NM_001193508
REST	hsa-miR-95-5p	82.2205	NM_001193508
REST	hsa-miR-4720-3p	82.0857	NM_001193508
REST	hsa-miR-6807-3p	81.9496	NM_001193508
REST	hsa-miR-1284	81.5393	NM_001193508
REST	hsa-miR-5588-5p	81.3862	NM_001193508
REST	hsa-miR-4799-3p	81.3862	NM_001193508
REST	hsa-miR-4720-5p	81.3862	NM_001193508
REST	hsa-miR-499a-5p	81.2685	NM_001193508

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Motifs and transcription factors (TFs) regulating REST

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
REST	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
REST	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
REST	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
REST	transfac_pro__M04826	EP300 (directAnnotation).
REST	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
REST	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
REST	transfac_pro__M00652	NRF1 (directAnnotation).
REST	hdpi__ETV4	ETV4 (directAnnotation).
REST	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
REST	taipale_tf_pairs__FLI1_FOXI1_RCCGGATGTTKWY_CAP	FLI1; FOXI1 (directAnnotation).
REST	taipale_tf_pairs__ELK1_FOXI1_RSCGGATGTKKN_CAP	ELK1; FOXI1 (directAnnotation).
REST	jaspar__MA1933.1	SREBF2 (directAnnotation).
REST	cisbp__M08198	ELF1 (directAnnotation).
REST	dbtfbs__ZNF121_HEK293_ENCSR224QDY_merged_N3	ZNF121 (directAnnotation).
REST	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
REST	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
REST	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
REST	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
REST	jaspar__MA1957.1	ELK1 (directAnnotation).
REST	transfac_pro__M06331	ZNF343 (directAnnotation).
REST	metacluster_135.11	NR2C2 (directAnnotation).
REST	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
REST	tfdimers__MD00038	TFAP2C (directAnnotation).
REST	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
REST	metacluster_7.13	ZFX (directAnnotation).
REST	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
REST	cisbp__M00968	MTF2 (directAnnotation).
REST	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
REST	cisbp__M00341	PAX6 (directAnnotation).
REST	metacluster_198.3	ZFP64 (directAnnotation).
REST	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
REST	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
REST	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
REST	cisbp__M00788	ZFY (inferredBy_Orthology).
REST	hdpi__ZNF304	ZNF304 (directAnnotation).
REST	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
REST	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
REST	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
REST	transfac_pro__M01199	TRIM28 (directAnnotation).
REST	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
REST	metacluster_151.2	ZNF23 (directAnnotation).
REST	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
REST	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
REST	transfac_pro__M03806	ZBTB7C (directAnnotation).
REST	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
REST	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
REST	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
REST	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
REST	transfac_pro__M04893	TAF1 (directAnnotation).
REST	hdpi__HIP2	UBE2K (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."