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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RDX

Summary for RDX

Gene information	Gene symbol	RDX
	Ensembl ID	ENSG00000137710
	Entrez ID	5962
	Gene name	radixin
	Synonyms	DFNB24
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RDX

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	0.584673	2.38e-06
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	-0.29232	3.60e-16
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.322439	2.21e-15
GSE149214	PC9 cell line	Cell line	Lung cancer	EGFR-mutated non-small cell lung cancer (NSCLC)	Targeted therapy	erlotinib	NA	Malignant cells	0.341933	1.28e-22
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.36144	0.00e+00
GSE104987	MCF7 cell line	Cell line	Breast cancer	ER+ breast cancer	Targeted therapy	KDM5-C70	NA	Malignant cells	-0.666683	0.00e+00
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.423053	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.429283	1.84e-32
GSE164897_Vem	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib	NA	Malignant cells	-0.412786	0.00e+00
GSE164897_VemCob	A375 cell line	Cell line	Melanoma	BRAFV600E-mutant melanoma	Targeted therapy	vemurafenib + combimetinib	NA	Malignant cells	-0.788159	0.00e+00

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Expression of RDX in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RDX

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RDX

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RDX	hsa-miR-3662	85.5156	NM_002906
RDX	hsa-miR-4786-3p	84.974	NM_001260492
RDX	hsa-miR-548e-5p	84.8028	NM_002906
RDX	hsa-miR-4458	84.3992	NM_002906
RDX	hsa-let-7d-5p	84.3992	NM_002906
RDX	hsa-miR-4760-5p	84.3528	NM_002906
RDX	hsa-miR-3714	84.2381	NM_002906
RDX	hsa-miR-1468-3p	84.2198	NM_002906
RDX	hsa-miR-302c-3p	84.1481	NM_002906
RDX	hsa-miR-302b-3p	84.1481	NM_002906
RDX	hsa-miR-302a-3p	84.1481	NM_002906
RDX	hsa-miR-302d-3p	84.1481	NM_002906
RDX	hsa-miR-8061	83.554	NM_002906
RDX	hsa-miR-1294	83.3269	NM_002906
RDX	hsa-miR-589-3p	83.0871	NM_001260492
RDX	hsa-miR-2053	82.9046	NM_002906
RDX	hsa-miR-200b-3p	82.6542	NM_002906
RDX	hsa-miR-429	82.6542	NM_002906
RDX	hsa-miR-200c-3p	82.6542	NM_002906
RDX	hsa-miR-4664-5p	82.4135	NM_001260492
RDX	hsa-miR-221-3p	82.4018	NM_001260492
RDX	hsa-miR-222-3p	82.4018	NM_001260492
RDX	hsa-miR-6833-5p	82.2956	NM_002906
RDX	hsa-miR-570-5p	82.1648	NM_002906
RDX	hsa-miR-548ai	82.1648	NM_002906
RDX	hsa-miR-548ag	82.1648	NM_002906
RDX	hsa-miR-548ba	82.1648	NM_002906
RDX	hsa-miR-421	82.0433	NM_002906
RDX	hsa-miR-185-5p	81.8051	NM_001260492
RDX	hsa-miR-4644	81.8051	NM_001260492
RDX	hsa-miR-654-3p	81.229	NM_002906
RDX	hsa-miR-6835-3p	81.1221	NM_002906
RDX	hsa-miR-137-3p	80.8082	NM_001260492
RDX	hsa-miR-877-5p	80.737	NM_001260493
RDX	hsa-miR-548an	80.5956	NM_001260492
RDX	hsa-let-7a-3p	80.5163	NM_001260492
RDX	hsa-let-7b-3p	80.5163	NM_001260492
RDX	hsa-let-7f-1-3p	80.5163	NM_001260492
RDX	hsa-miR-98-3p	80.5163	NM_001260492

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Motifs and transcription factors (TFs) regulating RDX

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RDX	homer__TWVGGTCCGC_HINFP	HINFP (directAnnotation).
RDX	transfac_pro__M06534	ZNF563 (directAnnotation).
RDX	metacluster_111.6	GMEB1; GMEB2 (directAnnotation).
RDX	transfac_pro__M06526	ZNF555 (directAnnotation).
RDX	transfac_pro__M05547	PLAGL1 (inferredBy_Orthology).
RDX	jaspar__MA0748.2	YY2 (directAnnotation).
RDX	transfac_pro__M05298	OVOL3 (directAnnotation).
RDX	metacluster_7.13	ZFX (directAnnotation).
RDX	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RDX	transfac_pro__M05578	ZFP92 (inferredBy_Orthology).
RDX	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RDX	metacluster_151.2	ZNF23 (directAnnotation).
RDX	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RDX	transfac_pro__M05479	ZNF580 (directAnnotation).
RDX	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RDX	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
RDX	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RDX	metacluster_182.10	ZFX (directAnnotation).
RDX	hdpi__ETV4	ETV4 (directAnnotation).
RDX	transfac_pro__M06071	ZNF814 (directAnnotation).
RDX	transfac_pro__M05628	ZNF735 (directAnnotation).
RDX	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
RDX	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RDX	jaspar__MA0079.5	SP1 (directAnnotation).
RDX	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RDX	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RDX	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RDX	transfac_pro__M04617	ZBTB7A (directAnnotation).
RDX	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RDX	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RDX	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RDX	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RDX	transfac_pro__M07387	ZBTB7A (directAnnotation).
RDX	transfac_pro__M07436	WT1 (directAnnotation).
RDX	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RDX	transfac_pro__M00716	ZBTB14 (directAnnotation).
RDX	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RDX	hdpi__HIP2	UBE2K (directAnnotation).
RDX	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RDX	transfac_pro__M04893	TAF1 (directAnnotation).
RDX	transfac_pro__M03876	ZBTB33 (directAnnotation).
RDX	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RDX	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RDX	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RDX	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RDX	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RDX	transfac_pro__M05894	ZNF565 (directAnnotation).
RDX	metacluster_22.11	NFE2 (directAnnotation).
RDX	transfac_pro__M01245	MTERF1 (directAnnotation).
RDX	transfac_pro__M06359	ZNF562 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RDX	"1D-myo-inositol 1,4,5-trisphosphate"	DB03401	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."