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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene (This gene does not contain this module)
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RC3H1

Summary for RC3H1

Gene information	Gene symbol	RC3H1
	Ensembl ID	ENSG00000135870
	Entrez ID	149041
	Gene name	ring finger and CCCH-type domains 1
	Synonyms	KIAA2025\|RNF198\|roquin\|RP5-1198E17.5
	Gene type	protein_coding
	UniProtAcc	Q5TC82

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Dataset with differentially expressed gene: RC3H1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.458907	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.261172	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.34269	2.16e-34

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Expression of RC3H1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RC3H1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RC3H1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RC3H1	hsa-miR-548as-5p	96.6945	NM_001300851
RC3H1	hsa-miR-548am-5p	96.6945	NM_001300851
RC3H1	hsa-miR-548ay-5p	96.6945	NM_001300851
RC3H1	hsa-miR-548a-5p	96.6945	NM_001300851
RC3H1	hsa-miR-548i	96.6945	NM_001300851
RC3H1	hsa-miR-4282	96.3879	NM_001300850
RC3H1	hsa-miR-548aq-5p	96.2119	NM_001300851
RC3H1	hsa-miR-98-3p	95.8954	NM_001300850
RC3H1	hsa-let-7f-1-3p	95.8954	NM_001300850
RC3H1	hsa-let-7b-3p	95.8954	NM_001300850
RC3H1	hsa-let-7a-3p	95.8954	NM_001300850
RC3H1	hsa-miR-561-3p	95.2335	NM_001300851
RC3H1	hsa-miR-4729	95.1767	NM_001300850
RC3H1	hsa-miR-5692b	95.1412	NM_001300851
RC3H1	hsa-miR-5692c	95.1412	NM_001300851
RC3H1	hsa-miR-7-1-3p	95.1327	NM_001300851
RC3H1	hsa-miR-145-5p	95.0795	NM_001300850
RC3H1	hsa-miR-5195-3p	95.0795	NM_001300850
RC3H1	hsa-miR-369-3p	95.0011	NM_001300851
RC3H1	hsa-miR-4775	94.862	NM_001300851
RC3H1	hsa-miR-4735-5p	94.7512	NM_001300851
RC3H1	hsa-miR-548at-5p	94.6282	NM_001300850
RC3H1	hsa-miR-6845-3p	94.5844	NM_001300851
RC3H1	hsa-miR-1185-1-3p	94.365	NM_001300850
RC3H1	hsa-let-7f-2-3p	94.365	NM_001300850
RC3H1	hsa-miR-1185-2-3p	94.365	NM_001300850
RC3H1	hsa-miR-7-2-3p	94.2695	NM_001300851
RC3H1	hsa-miR-142-5p	94.1578	NM_001300851
RC3H1	hsa-miR-5590-3p	94.1578	NM_001300851
RC3H1	hsa-miR-513c-5p	94.1331	NM_001300851
RC3H1	hsa-miR-3125	94.0567	NM_001300850
RC3H1	hsa-miR-651-3p	94.0013	NM_001300851
RC3H1	hsa-miR-3192-3p	93.9511	NM_001300850
RC3H1	hsa-miR-10527-5p	93.8933	NM_001300850
RC3H1	hsa-miR-410-3p	93.7617	NM_001300850
RC3H1	hsa-miR-216a-5p	93.6972	NM_001300851
RC3H1	hsa-miR-608	93.6922	NM_001300851
RC3H1	hsa-miR-4651	93.6922	NM_001300851
RC3H1	hsa-miR-1277-5p	93.6834	NM_001300851
RC3H1	hsa-miR-4668-5p	93.3578	NM_001300851
RC3H1	hsa-miR-3916	93.2477	NM_001300850
RC3H1	hsa-miR-6859-5p	93.2477	NM_001300850
RC3H1	hsa-miR-6081	93.0844	NM_001300850
RC3H1	hsa-miR-576-5p	92.6265	NM_001300851
RC3H1	hsa-miR-514b-5p	92.4734	NM_001300851
RC3H1	hsa-miR-3685	92.4144	NM_001300851
RC3H1	hsa-miR-4698	91.8899	NM_001300850
RC3H1	hsa-miR-4276	91.6081	NM_001300850
RC3H1	hsa-miR-3160-5p	91.6004	NM_001300851
RC3H1	hsa-miR-5692a	91.5681	NM_001300851

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Motifs and transcription factors (TFs) regulating RC3H1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."