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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RBM47

Summary for RBM47

Gene information	Gene symbol	RBM47
	Ensembl ID	ENSG00000163694
	Entrez ID	54502
	Gene name	RNA binding motif protein 47
	Synonyms	FLJ20273\|NET18
	Gene type	protein_coding
	UniProtAcc	A0AV96

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Dataset with differentially expressed gene: RBM47

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.26325	0.00e+00
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Malignant cells	0.349892	5.56e-17
GSE139386	H3122 cell line	Cell line	Lung cancer	EML4-ALK fusion-positive non-small cell lung cancer (NSCLC)	Targeted therapy	ceritinib	NA	Malignant cells	-0.336689	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.433329	1.57e-21

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Expression of RBM47 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RBM47

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RBM47

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RBM47	hsa-miR-3143	86.4451	NM_001098634
RBM47	hsa-miR-5689	86.414	NM_001098634
RBM47	hsa-miR-25-3p	86.3062	NM_001098634
RBM47	hsa-miR-122-5p	85.7791	NM_001098634
RBM47	hsa-miR-6739-3p	85.4737	NM_001098634
RBM47	hsa-miR-646	84.8607	NM_001098634
RBM47	hsa-miR-5680	84.1472	NM_001098634
RBM47	hsa-miR-4262	84.0136	NM_001098634
RBM47	hsa-miR-5093	83.4434	NM_001098634
RBM47	hsa-miR-203a-3p	83.4088	NM_001098634
RBM47	hsa-miR-199b-3p	83.1608	NM_001098634
RBM47	hsa-miR-3129-5p	83.1608	NM_001098634
RBM47	hsa-miR-199a-3p	83.1608	NM_001098634
RBM47	hsa-miR-1248	82.2299	NM_001098634
RBM47	hsa-miR-4325	81.1436	NM_001098634
RBM47	hsa-miR-6768-3p	80.7531	NM_001098634
RBM47	hsa-miR-153-5p	80.0481	NM_001098634

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Motifs and transcription factors (TFs) regulating RBM47

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RBM47	dbtfbs__E2F8_representative_N1	E2F8 (directAnnotation).
RBM47	transfac_pro__M04950	EGR1 (directAnnotation).
RBM47	metacluster_15.3	E2F1; E2F6; E2F8; E2F8; TFDP1 (directAnnotation). E2F3 (inferredBy_Orthology).
RBM47	taipale_cyt_meth__E2F2_GCGCGCGCGYW_eDBD_repr	E2F2 (directAnnotation).
RBM47	taipale_tf_pairs__ELK1_EOMES_RSCGGAANNAGGYGYNA_CAP_repr	ELK1; EOMES (directAnnotation).
RBM47	taipale_tf_pairs__ERF_HES7_NNCACGTGNNNNCCGGAANN_CAP_repr	ERF; HES7 (directAnnotation).
RBM47	cisbp__M08198	ELF1 (directAnnotation).
RBM47	transfac_pro__M00652	NRF1 (directAnnotation).
RBM47	hdpi__ETV4	ETV4 (directAnnotation).
RBM47	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RBM47	transfac_pro__M04866	HDAC2 (directAnnotation).
RBM47	jaspar__MA1122.1	TFDP1 (directAnnotation).
RBM47	swissregulon__hs__ZBTB14	ZBTB14 (directAnnotation).
RBM47	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RBM47	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RBM47	cisbp__M00341	PAX6 (directAnnotation).
RBM47	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RBM47	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RBM47	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RBM47	metacluster_175.1	ZNF283 (directAnnotation).
RBM47	hdpi__ZNF304	ZNF304 (directAnnotation).
RBM47	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RBM47	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RBM47	transfac_pro__M01199	TRIM28 (directAnnotation).
RBM47	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RBM47	metacluster_151.2	ZNF23 (directAnnotation).
RBM47	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RBM47	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RBM47	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RBM47	transfac_pro__M06484	ZNF683 (directAnnotation).
RBM47	transfac_pro__M05753	ZNF630 (directAnnotation).
RBM47	transfac_pro__M02933	ZBTB14 (inferredBy_Orthology).
RBM47	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
RBM47	metacluster_155.34	PRDM4 (directAnnotation).
RBM47	metacluster_168.11	ZNF771; ZNF771 (directAnnotation).
RBM47	metacluster_131.3	ZNF436 (inferredBy_Orthology).
RBM47	metacluster_92.4	ZNF33B (directAnnotation).
RBM47	transfac_pro__M05737	ZNF699 (directAnnotation).
RBM47	tfdimers__MD00364	WT1 (directAnnotation).
RBM47	transfac_pro__M06173	ZNF85 (directAnnotation).
RBM47	jaspar__MA1650.1	ZBTB14 (directAnnotation).
RBM47	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
RBM47	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
RBM47	tfdimers__MD00483	ZBTB14 (directAnnotation).
RBM47	kznf__ZNF846_Imbeault2017_OM_MEME	ZNF846 (directAnnotation).
RBM47	transfac_pro__M04817	ZBTB33 (directAnnotation).
RBM47	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."