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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RASSF8

Summary for RASSF8

Gene information	Gene symbol	RASSF8
	Ensembl ID	ENSG00000123094
	Entrez ID	11228
	Gene name	Ras association domain family member 8
	Synonyms	C12orf2\|HoJ-1
	Gene type	protein_coding
	UniProtAcc	Q8NHQ8

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Dataset with differentially expressed gene: RASSF8

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.821418	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.652636	0.00e+00

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Expression of RASSF8 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RASSF8

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RASSF8	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RASSF8

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RASSF8	hsa-miR-6878-5p	89.5998	NM_001164747
RASSF8	hsa-miR-4775	89.2059	NM_007211
RASSF8	hsa-miR-144-3p	89.0855	NM_007211
RASSF8	hsa-miR-146a-3p	88.1042	NM_001164747
RASSF8	hsa-miR-629-5p	88.0577	NM_007211
RASSF8	hsa-miR-4277	87.9981	NM_001164747
RASSF8	hsa-miR-4753-5p	87.8522	NM_001164746
RASSF8	hsa-miR-3085-3p	87.597	NM_001164746
RASSF8	hsa-miR-3064-5p	87.597	NM_001164746
RASSF8	hsa-miR-6504-5p	87.597	NM_001164746
RASSF8	hsa-miR-516b-5p	87.5659	NM_001164747
RASSF8	hsa-miR-383-5p	87.3702	NM_001164747
RASSF8	hsa-miR-9-3p	87.0663	NM_001164746
RASSF8	hsa-miR-4262	86.8427	NM_001164746
RASSF8	hsa-miR-1287-5p	86.8254	NM_001164746
RASSF8	hsa-miR-6839-3p	86.6979	NM_007211
RASSF8	hsa-miR-6071	86.5979	NM_001164747
RASSF8	hsa-miR-6740-3p	86.569	NM_007211
RASSF8	hsa-miR-5011-5p	86.3336	NM_001164747
RASSF8	hsa-miR-513a-3p	86.3314	NM_001164747
RASSF8	hsa-miR-513c-3p	86.3314	NM_001164747
RASSF8	hsa-miR-3135b	86.1352	NM_001164746
RASSF8	hsa-miR-506-3p	85.7473	NM_001164746
RASSF8	hsa-miR-124-3p	85.7473	NM_001164746
RASSF8	hsa-miR-3978	85.636	NM_001164747
RASSF8	hsa-miR-606	85.3667	NM_001164747
RASSF8	hsa-miR-29b-1-5p	85.3155	NM_001164746
RASSF8	hsa-miR-551b-5p	85.1565	NM_001164747
RASSF8	hsa-miR-4698	85.1444	NM_001164747
RASSF8	hsa-miR-3606-3p	85.1264	NM_001164747
RASSF8	hsa-miR-559	84.9075	NM_001164746
RASSF8	hsa-miR-548bb-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548as-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548i	84.8777	NM_001164746
RASSF8	hsa-miR-548h-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548ae-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548b-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548o-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548y	84.8777	NM_001164746
RASSF8	hsa-miR-548aq-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548d-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548am-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548a-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548w	84.8777	NM_001164746
RASSF8	hsa-miR-548ad-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548c-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548ab	84.8777	NM_001164746
RASSF8	hsa-miR-548ap-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548au-5p	84.8777	NM_001164746
RASSF8	hsa-miR-548ar-5p	84.8777	NM_001164746

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Motifs and transcription factors (TFs) regulating RASSF8

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RASSF8	metacluster_135.11	NR2C2 (directAnnotation).
RASSF8	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RASSF8	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RASSF8	metacluster_7.13	ZFX (directAnnotation).
RASSF8	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RASSF8	cisbp__M00968	MTF2 (directAnnotation).
RASSF8	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RASSF8	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RASSF8	cisbp__M00341	PAX6 (directAnnotation).
RASSF8	metacluster_198.3	ZFP64 (directAnnotation).
RASSF8	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RASSF8	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RASSF8	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RASSF8	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RASSF8	cisbp__M00788	ZFY (inferredBy_Orthology).
RASSF8	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RASSF8	metacluster_175.1	ZNF283 (directAnnotation).
RASSF8	hdpi__ZNF304	ZNF304 (directAnnotation).
RASSF8	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RASSF8	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RASSF8	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RASSF8	transfac_pro__M01199	TRIM28 (directAnnotation).
RASSF8	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RASSF8	metacluster_151.2	ZNF23 (directAnnotation).
RASSF8	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RASSF8	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RASSF8	transfac_pro__M03806	ZBTB7C (directAnnotation).
RASSF8	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RASSF8	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RASSF8	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
RASSF8	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RASSF8	cisbp__M00249	WT1 (directAnnotation).
RASSF8	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RASSF8	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RASSF8	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RASSF8	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RASSF8	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RASSF8	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."