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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target

Gene: RARB

Summary for RARB

Gene information	Gene symbol	RARB
	Ensembl ID	ENSG00000077092
	Entrez ID	5915
	Gene name	retinoic acid receptor beta
	Synonyms	HAP\|NR1B2\|RAR-beta\|RARbeta\|RRB2
	Gene type	protein_coding
	UniProtAcc	P10826

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Dataset with differentially expressed gene: RARB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	5.34181	7.99e-07

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Expression of RARB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RARB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RARB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RARB	hsa-miR-3182	84.2196	NM_000965
RARB	hsa-miR-526b-5p	84.2184	NM_001290266
RARB	hsa-miR-4776-3p	84.1733	NM_000965
RARB	hsa-miR-6859-5p	83.9144	NM_001290266
RARB	hsa-miR-3916	83.9144	NM_001290266
RARB	hsa-miR-3125	83.9144	NM_001290266
RARB	hsa-miR-6868-5p	83.8612	NM_000965
RARB	hsa-miR-5011-5p	83.5086	NM_001290266
RARB	hsa-miR-133b	82.1877	NM_000965
RARB	hsa-miR-133a-3p	82.1877	NM_000965
RARB	hsa-miR-1183	82.0284	NM_000965
RARB	hsa-miR-2110	80.7953	NM_000965
RARB	hsa-miR-497-3p	80.0091	NM_001290266

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Motifs and transcription factors (TFs) regulating RARB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RARB	kznf__ZNF594_Schmitges2016_RCADE	ZNF594 (directAnnotation).
RARB	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RARB	hocomoco__KLF13_HUMAN.H11MO.0.D	KLF13 (directAnnotation).
RARB	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
RARB	transfac_pro__M04617	ZBTB7A (directAnnotation).
RARB	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
RARB	kznf__ZNF529_Imbeault2017_RP_ChIP-seq	ZNF529 (directAnnotation).
RARB	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RARB	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
RARB	transfac_pro__M07387	ZBTB7A (directAnnotation).
RARB	transfac_pro__M07436	WT1 (directAnnotation).
RARB	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RARB	transfac_pro__M00716	ZBTB14 (directAnnotation).
RARB	swissregulon__hs__CHD1	CHD1 (directAnnotation).
RARB	hdpi__HIP2	UBE2K (directAnnotation).
RARB	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
RARB	metacluster_170.2	KLF1; KLF10; KLF10; KLF11; KLF11; KLF11; KLF12; KLF12; KLF14; KLF15; KLF17; KLF2; KLF5; KLF7; KLF7; KLF8; MAZ; MAZ; PATZ1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP2; SP4; SP4; SP5; SP6; SP7; SP8; SP9; ZNF281 (directAnnotation). E2F1; E2F4; KLF10; KLF13; KLF14; KLF17; KLF2; KLF7; SP1; SP1; SP3; SP4; SP5; SP6; SP7 (inferredBy_Orthology).
RARB	transfac_pro__M04893	TAF1 (directAnnotation).
RARB	transfac_pro__M03876	ZBTB33 (directAnnotation).
RARB	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
RARB	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RARB	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
RARB	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RARB	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

Target name	Drug name	Drug ID	Drug type
RARB	"Acitretin"	DB00459	small molecule
RARB	"Adapalene"	DB00210	small molecule
RARB	"Alitretinoin"	DB00523	small molecule
RARB	"Arotinoid acid"	DB02877	small molecule
RARB	"Etretinate"	DB00926	small molecule
RARB	"LGD-1550"	DB05785	small molecule
RARB	"Tamibarotene"	DB04942	small molecule
RARB	"Tazarotene"	DB00799	small molecule
RARB	"Tretinoin"	DB00755	small molecule
RARB	"Trifarotene"	DB12808	small molecule

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1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."