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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAPH1

Summary for RAPH1

Gene information	Gene symbol	RAPH1
	Ensembl ID	ENSG00000173166
	Entrez ID	65059
	Gene name	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1
	Synonyms	ALS2CR18\|ALS2CR9\|KIAA1681
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAPH1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1	NA	Malignant cells	0.321562	7.43e-24
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.588511	0.00e+00

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Expression of RAPH1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAPH1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAPH1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAPH1	hsa-miR-545-5p	90.2313	NM_213589
RAPH1	hsa-miR-10399-5p	90.0979	NM_213589
RAPH1	hsa-miR-4724-3p	89.6869	NM_213589
RAPH1	hsa-miR-6833-3p	89.6388	NM_213589
RAPH1	hsa-miR-6504-3p	89.5416	NM_213589
RAPH1	hsa-miR-6834-5p	89.3735	NM_213589
RAPH1	hsa-miR-3163	89.1763	NM_213589
RAPH1	hsa-miR-6731-3p	89.1598	NM_213589
RAPH1	hsa-miR-3140-5p	88.808	NM_213589
RAPH1	hsa-miR-1250-3p	88.6591	NM_213589
RAPH1	hsa-miR-4427	88.4197	NM_213589
RAPH1	hsa-miR-3942-3p	88.3138	NM_213589
RAPH1	hsa-miR-4786-3p	88.0686	NM_213589
RAPH1	hsa-miR-6817-3p	87.8503	NM_213589
RAPH1	hsa-miR-4520-3p	87.3587	NM_213589
RAPH1	hsa-miR-133a-3p	87.0976	NM_213589
RAPH1	hsa-miR-133b	87.0976	NM_213589
RAPH1	hsa-miR-323a-3p	86.9432	NM_213589
RAPH1	hsa-miR-4789-5p	86.5386	NM_213589
RAPH1	hsa-miR-6809-3p	85.7838	NM_213589
RAPH1	hsa-miR-936	85.7625	NM_213589
RAPH1	hsa-miR-541-5p	85.7311	NM_213589
RAPH1	hsa-miR-3121-3p	85.6941	NM_213589
RAPH1	hsa-miR-4768-5p	85.6319	NM_213589
RAPH1	hsa-let-7b-3p	85.5402	NM_213589
RAPH1	hsa-let-7f-1-3p	85.5402	NM_213589
RAPH1	hsa-miR-98-3p	85.5402	NM_213589
RAPH1	hsa-let-7a-3p	85.5402	NM_213589
RAPH1	hsa-miR-539-5p	85.4113	NM_213589
RAPH1	hsa-miR-4441	85.0961	NM_213589
RAPH1	hsa-miR-3663-3p	84.6842	NM_213589
RAPH1	hsa-miR-3609	84.5774	NM_213589
RAPH1	hsa-miR-510-3p	84.5299	NM_213589
RAPH1	hsa-miR-381-3p	84.5237	NM_213589
RAPH1	hsa-miR-300	84.5237	NM_213589
RAPH1	hsa-miR-548ah-5p	84.4174	NM_213589
RAPH1	hsa-miR-558	84.2056	NM_213589
RAPH1	hsa-miR-5680	83.7388	NM_213589
RAPH1	hsa-miR-3161	83.6042	NM_213589
RAPH1	hsa-miR-4727-5p	83.3679	NM_213589
RAPH1	hsa-miR-548ar-3p	83.0498	NM_213589
RAPH1	hsa-miR-513a-3p	82.4572	NM_213589
RAPH1	hsa-miR-513c-3p	82.4572	NM_213589
RAPH1	hsa-miR-4270	82.3326	NM_213589
RAPH1	hsa-miR-4266	82.2633	NM_213589
RAPH1	hsa-miR-3613-3p	82.0675	NM_213589
RAPH1	hsa-miR-6873-3p	82.0355	NM_213589
RAPH1	hsa-miR-4789-3p	82.0133	NM_213589
RAPH1	hsa-miR-491-3p	81.5964	NM_213589
RAPH1	hsa-miR-493-5p	81.5929	NM_213589

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Motifs and transcription factors (TFs) regulating RAPH1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAPH1	jaspar__MA0079.5	SP1 (directAnnotation).
RAPH1	kznf__KLF1_Barrera2016.2_PBM	KLF1 (directAnnotation).
RAPH1	transfac_pro__M01253	CNOT3 (directAnnotation).
RAPH1	transfac_pro__M04817	ZBTB33 (directAnnotation).
RAPH1	cisbp__M07938	E2F1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."