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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAP2C

Summary for RAP2C

Gene information	Gene symbol	RAP2C
	Ensembl ID	ENSG00000123728
	Entrez ID	57826
	Gene name	RAP2C, member of RAS oncogene family
	Synonyms	DKFZp313B211
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: RAP2C

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pac	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + paclitaxel	NA	Malignant cells	-0.254715	1.36e-10
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	-0.262069	1.01e-16

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Expression of RAP2C in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAP2C

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAP2C

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAP2C	hsa-miR-106a-5p	92.3686	NM_001271186
RAP2C	hsa-miR-20b-5p	92.3686	NM_001271186
RAP2C	hsa-miR-93-5p	92.3686	NM_001271186
RAP2C	hsa-miR-519d-3p	92.3686	NM_001271186
RAP2C	hsa-miR-4772-3p	92.0259	NM_001271186
RAP2C	hsa-miR-3662	92.019	NM_001271186
RAP2C	hsa-miR-10397-3p	91.4516	NM_001271186
RAP2C	hsa-miR-3910	91.0372	NM_001271186
RAP2C	hsa-miR-4682	90.8603	NM_001271186
RAP2C	hsa-miR-600	90.6288	NM_001271186
RAP2C	hsa-miR-519b-3p	90.5365	NM_001271186
RAP2C	hsa-miR-519c-3p	90.5365	NM_001271186
RAP2C	hsa-miR-519a-3p	90.5365	NM_001271186
RAP2C	hsa-miR-331-5p	90.2486	NM_001271186
RAP2C	hsa-miR-144-3p	89.9071	NM_001271186
RAP2C	hsa-miR-4738-3p	89.7388	NM_001271186
RAP2C	hsa-miR-3059-5p	89.4897	NM_001271186
RAP2C	hsa-miR-4672	88.991	NM_001271186
RAP2C	hsa-miR-6818-3p	88.8969	NM_001271186
RAP2C	hsa-miR-548c-3p	88.8581	NM_001271186
RAP2C	hsa-miR-3169	88.7569	NM_001271186
RAP2C	hsa-miR-6780a-3p	88.6742	NM_001271186
RAP2C	hsa-miR-7158-5p	88.2843	NM_001271186
RAP2C	hsa-miR-200a-3p	88.136	NM_001271186
RAP2C	hsa-miR-141-3p	88.136	NM_001271186
RAP2C	hsa-miR-4528	88.0688	NM_001271186
RAP2C	hsa-miR-137-3p	87.3279	NM_001271186
RAP2C	hsa-miR-217-5p	87.0634	NM_001271186
RAP2C	hsa-miR-3148	87.0435	NM_001271186
RAP2C	hsa-miR-7856-5p	86.9672	NM_001271186
RAP2C	hsa-miR-3184-3p	86.9569	NM_001271186
RAP2C	hsa-miR-12120	86.851	NM_001271186
RAP2C	hsa-miR-544a	86.7709	NM_001271186
RAP2C	hsa-miR-3613-3p	86.4428	NM_001271186
RAP2C	hsa-miR-24-3p	86.3464	NM_001271186
RAP2C	hsa-miR-548at-5p	86.0685	NM_001271186
RAP2C	hsa-miR-1256	85.8914	NM_001271186
RAP2C	hsa-miR-105-5p	85.8812	NM_001271186
RAP2C	hsa-miR-7853-5p	85.8812	NM_001271186
RAP2C	hsa-miR-4452	85.3893	NM_001271186
RAP2C	hsa-miR-4686	85.2802	NM_001271186
RAP2C	hsa-miR-133a-3p	85.2097	NM_001271186
RAP2C	hsa-miR-133b	85.2097	NM_001271186
RAP2C	hsa-miR-7160-5p	85.0979	NM_001271186
RAP2C	hsa-miR-3671	85.035	NM_001271186
RAP2C	hsa-miR-4666a-3p	84.9508	NM_001271186
RAP2C	hsa-miR-4493	84.8619	NM_001271186
RAP2C	hsa-miR-590-3p	84.7944	NM_001271186
RAP2C	hsa-miR-7153-3p	84.5551	NM_001271186
RAP2C	hsa-miR-12136	84.4634	NM_001271186

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Motifs and transcription factors (TFs) regulating RAP2C

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAP2C	taipale_tf_pairs__ETS2_RCCGGAAGTG_HT	ETS2 (directAnnotation).
RAP2C	metacluster_191.3	EHF; ELF1; ELF1; ELF1; ELF4; ELK1; ELK3; ELK3; ELK4; ELK4; ERF; ETS1; ETS2; ETV3; ETV4; ETV5; FEV; FEV; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; SPDEF; ZNF200 (directAnnotation). ELK1; ELK1; ELK3; ELK3; ELK4; ELK4; ETV1; ETV1; ETV4; ETV4; ETV4; ETV5; GABPA; GABPA (inferredBy_Orthology).
RAP2C	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RAP2C	metacluster_191.2	ELK4; NR2C2; NR2C2; NR2C2; NR2C2 (directAnnotation). GABPA (inferredBy_Orthology).
RAP2C	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
RAP2C	jaspar__MA1483.2	ELF2 (directAnnotation).
RAP2C	metacluster_166.2	ELK4; ETS1; ETS1; ETV1; ETV3; ETV4; ETV5; ETV7 (directAnnotation). GABPA (inferredBy_Orthology).
RAP2C	transfac_pro__M04826	EP300 (directAnnotation).
RAP2C	taipale_tf_pairs__ELK1_HOXA1_RCCGGAAGTAATTA_HT	ELK1; HOXA1 (directAnnotation).
RAP2C	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RAP2C	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RAP2C	taipale_tf_pairs__ELK1_EOMES_TNRCACCGGAAGN_CAP	ELK1; EOMES (directAnnotation).
RAP2C	hdpi__ETV4	ETV4 (directAnnotation).
RAP2C	cisbp__M02645	ETS1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV5_EVX1_RSCGGWAATKR_CAP	ETV5; EVX1 (directAnnotation).
RAP2C	taipale_tf_pairs__ELK1_TBX21_TNRCACCGGAAGNN_CAP_repr	ELK1; TBX21 (directAnnotation).
RAP2C	cisbp__M08198	ELF1 (directAnnotation).
RAP2C	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
RAP2C	jaspar__MA1708.1	ETV7 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV2_FOXO6_RCCGGATGTTKWN_CAP	ETV2; FOXO6 (directAnnotation).
RAP2C	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RAP2C	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RAP2C	hdpi__TP73	TP73 (directAnnotation).
RAP2C	hdpi__ELF2	ELF2 (directAnnotation).
RAP2C	swissregulon__hs__ELK1	ELK1 (directAnnotation).
RAP2C	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
RAP2C	metacluster_183.4	ETS1 (inferredBy_Orthology).
RAP2C	transfac_pro__M01298	MECP2 (directAnnotation).
RAP2C	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
RAP2C	metacluster_35.5	ELF1; ELF2; ELF3; ELF3; ELK1; ELK4; ERF; ERG; ETS1; ETS1; ETS2; ETV7; ETV7; FLI1; FLI1 (directAnnotation).
RAP2C	hdpi__FLI1	FLI1 (directAnnotation).
RAP2C	taipale_tf_pairs__HOXB2_ETV4_ACCGGAAATGAN_CAP	ETV4; HOXB2 (directAnnotation).
RAP2C	transfac_pro__M04862	NRF1 (directAnnotation).
RAP2C	transfac_pro__M00492	STAT1 (directAnnotation).
RAP2C	transfac_pro__M04848	TAF1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."