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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RALGPS2

Summary for RALGPS2

Gene information	Gene symbol	RALGPS2
	Ensembl ID	ENSG00000116191
	Entrez ID	55103
	Gene name	Ral GEF with PH domain and SH3 binding motif 2
	Synonyms	FLJ10244\|FLJ25604\|KIAA0351
	Gene type	protein_coding
	UniProtAcc	Q86X27

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Dataset with differentially expressed gene: RALGPS2

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.399729	7.01e-45
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	B cells	0.693935	2.91e-30
GSE207422_Sin	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	sintilimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	B cells	-0.491995	4.15e-06
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.566302	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	B cells	1.32455	4.26e-03
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	post	Malignant cells	0.278198	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.455589	0.00e+00

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Expression of RALGPS2 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RALGPS2

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RALGPS2

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RALGPS2	hsa-miR-4473	85.0679	NM_152663
RALGPS2	hsa-miR-122b-5p	84.8148	NM_152663
RALGPS2	hsa-miR-4699-3p	84.6388	NM_152663
RALGPS2	hsa-miR-183-3p	84.535	NM_152663
RALGPS2	hsa-miR-330-5p	84.3049	NM_152663
RALGPS2	hsa-miR-30d-3p	84.0724	NM_152663
RALGPS2	hsa-miR-30a-3p	84.0724	NM_152663
RALGPS2	hsa-miR-30e-3p	84.0724	NM_152663
RALGPS2	hsa-miR-182-5p	83.9185	NM_152663
RALGPS2	hsa-miR-448	83.791	NM_152663
RALGPS2	hsa-miR-4303	83.7691	NM_152663
RALGPS2	hsa-miR-6513-5p	83.344	NM_152663
RALGPS2	hsa-miR-3613-3p	83.2115	NM_152663
RALGPS2	hsa-miR-4652-3p	82.9963	NM_152663
RALGPS2	hsa-miR-548c-3p	82.8977	NM_152663
RALGPS2	hsa-miR-326	82.8072	NM_152663
RALGPS2	hsa-miR-141-3p	82.4537	NM_152663
RALGPS2	hsa-miR-539-5p	82.3432	NM_152663
RALGPS2	hsa-miR-101-3p	82.3384	NM_152663
RALGPS2	hsa-miR-506-3p	82.3297	NM_152663
RALGPS2	hsa-miR-124-3p	82.3297	NM_152663
RALGPS2	hsa-miR-374b-5p	82.169	NM_152663
RALGPS2	hsa-miR-551b-5p	81.467	NM_152663
RALGPS2	hsa-miR-200a-3p	81.2487	NM_152663
RALGPS2	hsa-miR-3680-3p	81.0093	NM_152663
RALGPS2	hsa-miR-186-5p	80.0667	NM_152663

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Motifs and transcription factors (TFs) regulating RALGPS2

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RALGPS2	transfac_pro__M06322	ZNF181 (directAnnotation).
RALGPS2	swissregulon__mm__Nkx2-3	NKX2-3 (inferredBy_Orthology).
RALGPS2	taipale_tf_pairs__MEIS1_ELF1_NTGCCGGAAGTN_CAP_repr	ELF1; MEIS1 (directAnnotation).
RALGPS2	taipale_tf_pairs__ETV5_FOXI1_TGTTGNCGGAWRN_CAP	ETV5; FOXI1 (directAnnotation).
RALGPS2	metacluster_16.7	SOX10; SOX11; SOX14; SOX14; SOX15; SOX18; SOX2; SOX2; SOX21; SOX21; SOX21; SOX7; SOX7; SOX7; SOX8; SOX8; SOX9; SRY (directAnnotation). SOX1; SOX1; SOX10; SOX21; SOX3 (inferredBy_Orthology).
RALGPS2	taipale_tf_pairs__GCM1_ELK1_RTGCGGGCGGAAGTN_CAP_2	ELK1; GCM1 (directAnnotation).
RALGPS2	tfdimers__MD00145	ELF1; ELF2; ELK1; ELK4; ERF; ERG; ETS1; ETS2; ETV7; FLI1; TCF7L2 (directAnnotation).
RALGPS2	metacluster_135.11	NR2C2 (directAnnotation).
RALGPS2	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RALGPS2	tfdimers__MD00038	TFAP2C (directAnnotation).
RALGPS2	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RALGPS2	metacluster_7.13	ZFX (directAnnotation).
RALGPS2	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RALGPS2	cisbp__M00968	MTF2 (directAnnotation).
RALGPS2	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RALGPS2	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RALGPS2	cisbp__M00341	PAX6 (directAnnotation).
RALGPS2	metacluster_198.3	ZFP64 (directAnnotation).
RALGPS2	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RALGPS2	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RALGPS2	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RALGPS2	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RALGPS2	cisbp__M00788	ZFY (inferredBy_Orthology).
RALGPS2	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RALGPS2	metacluster_175.1	ZNF283 (directAnnotation).
RALGPS2	hdpi__ZNF304	ZNF304 (directAnnotation).
RALGPS2	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RALGPS2	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RALGPS2	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RALGPS2	transfac_pro__M01199	TRIM28 (directAnnotation).
RALGPS2	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RALGPS2	metacluster_151.2	ZNF23 (directAnnotation).
RALGPS2	transfac_public__M00189	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RALGPS2	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RALGPS2	transfac_pro__M03806	ZBTB7C (directAnnotation).
RALGPS2	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RALGPS2	jaspar__MA1708.1	ETV7 (directAnnotation).
RALGPS2	taipale_tf_pairs__TEAD4_ELK1_RMATWCCGGAWRN_CAP_repr	ELK1; TEAD4 (directAnnotation).
RALGPS2	metacluster_166.4	BCLAF1; EHF; ELF1; ELF1; ELF1; ELF1; ELF1; ELF1; ELF2; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK1; ELK3; ELK3; ELK3; ELK3; ELK4; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS1; ETS1; ETS1; ETV1; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV4; ETV4; ETV4; ETV4; ETV5; ETV7; FEV; FEV; FLI1; FLI1; FLI1; FLI1; GABPA; GABPA; GABPA; GABPA; GABPA; GABPA; GABPB1; GATAD1; PHF20; ZBTB25; ZBTB40 (directAnnotation). EHF; ELF1; ELF1; ELF3; ELF5; ELK3; ELK4; ERG; ETS1; ETV1; ETV2; ETV4; FLI1; GABPA; GABPA (inferredBy_Orthology).
RALGPS2	transfac_pro__M06267	ZNF805 (directAnnotation).
RALGPS2	taipale_tf_pairs__FOXO1_ELK3_RCCGGAWGTKKW_CAP	ELK3; FOXO1 (directAnnotation).
RALGPS2	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
RALGPS2	transfac_pro__M05636	ZNF134; ZNF154; ZNF256; ZNF304; ZNF418; ZNF419; ZNF480; ZNF548; ZNF549; ZNF552; ZNF561; ZNF562; ZNF584; ZNF586; ZNF587B; ZNF610; ZNF772; ZNF773; ZNF792; ZNF793; ZNF837 (inferredBy_Orthology).
RALGPS2	taipale_tf_pairs__ETV2_DRGX_RSCGGAWRYATTA_CAP_repr	DRGX; ETV2 (directAnnotation).
RALGPS2	transfac_pro__M06334	ZNF782 (directAnnotation).
RALGPS2	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
RALGPS2	taipale__MYBL2_DBD_AACCGTTAACGGNN	MYBL2 (directAnnotation).
RALGPS2	hdpi__NRL	NRL (directAnnotation).
RALGPS2	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RALGPS2	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."