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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB30

Summary for RAB30

Gene information	Gene symbol	RAB30
	Ensembl ID	ENSG00000137502
	Entrez ID	27314
	Gene name	RAB30, member RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	Q15771

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Dataset with differentially expressed gene: RAB30

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE169246_PacTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	post	Plasma cells	-0.325649	1.99e-03
GSE169246_PacAteTissue	patients	Tumor tissue	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	B cells	-0.311091	7.65e-03
GSE207422_Tor	patients	Tumor tissue	Lung cancer	EGFR/ALK mutation negative non-small cell lung cancer (NSCLC)	Immunotherapy	toripalimab + carboplatin + (docetaxel or pemetrexed or emcitabine)	post	Plasma cells	0.499225	2.88e-06
GSE161801_IMiD	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Targeted therapy	pomalidomide + dexamethasone OR lenalidomide + dexamethasone	pre	Malignant cells	0.621553	0.00e+00

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Expression of RAB30 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB30

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB30

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB30	hsa-miR-3143	86.5318	NM_001286059
RAB30	hsa-miR-410-3p	86.5311	NM_001286060
RAB30	hsa-miR-3148	86.5296	NM_001286060
RAB30	hsa-miR-4441	85.8444	NM_001286060
RAB30	hsa-miR-15a-5p	85.3808	NM_001286059
RAB30	hsa-miR-4527	85.1911	NM_001286059
RAB30	hsa-miR-888-5p	85.1156	NM_001286060
RAB30	hsa-miR-4728-5p	85.1031	NM_001286060
RAB30	hsa-miR-4803	84.4876	NM_001286059
RAB30	hsa-miR-8063	84.4055	NM_001286060
RAB30	hsa-miR-6848-3p	84.2973	NM_001286059
RAB30	hsa-miR-6843-3p	84.2973	NM_001286059
RAB30	hsa-miR-195-5p	84.2572	NM_001286059
RAB30	hsa-miR-15b-5p	84.2572	NM_001286059
RAB30	hsa-miR-16-5p	84.2572	NM_001286059
RAB30	hsa-miR-1305	84.0749	NM_001286060
RAB30	hsa-miR-3155a	84.0732	NM_001286060
RAB30	hsa-miR-484	84.0732	NM_001286060
RAB30	hsa-miR-3155b	84.0732	NM_001286060
RAB30	hsa-miR-454-3p	83.9991	NM_001286059
RAB30	hsa-miR-6838-5p	83.9002	NM_001286059
RAB30	hsa-miR-5093	83.7892	NM_001286060
RAB30	hsa-miR-6797-5p	83.4815	NM_001286059
RAB30	hsa-miR-1249-5p	83.4815	NM_001286059
RAB30	hsa-miR-6885-3p	83.3735	NM_001286060
RAB30	hsa-miR-130b-3p	82.9422	NM_001286059
RAB30	hsa-miR-3666	82.9422	NM_001286059
RAB30	hsa-miR-6124	82.6184	NM_001286060
RAB30	hsa-miR-4295	82.5471	NM_001286059
RAB30	hsa-miR-7856-5p	82.3689	NM_001286059
RAB30	hsa-miR-6083	82.2401	NM_001286060
RAB30	hsa-miR-6785-5p	81.8949	NM_001286060
RAB30	hsa-miR-409-3p	81.8736	NM_001286060
RAB30	hsa-miR-4306	81.8386	NM_001286060
RAB30	hsa-miR-590-3p	81.828	NM_001286059
RAB30	hsa-miR-190a-3p	81.3837	NM_001286060
RAB30	hsa-miR-205-3p	81.1152	NM_001286059
RAB30	hsa-miR-20a-5p	80.7211	NM_001286059
RAB30	hsa-miR-106b-5p	80.7211	NM_001286059
RAB30	hsa-miR-627-3p	80.6058	NM_001286060
RAB30	hsa-miR-17-5p	80.592	NM_001286059
RAB30	hsa-miR-106a-5p	80.592	NM_001286059
RAB30	hsa-miR-20b-5p	80.592	NM_001286059
RAB30	hsa-miR-519d-3p	80.592	NM_001286059
RAB30	hsa-miR-93-5p	80.592	NM_001286059
RAB30	hsa-miR-3646	80.5812	NM_001286059
RAB30	hsa-miR-424-5p	80.4792	NM_001286059
RAB30	hsa-miR-497-5p	80.4792	NM_001286059
RAB30	hsa-miR-3529-3p	80.1587	NM_001286060
RAB30	hsa-miR-9851-5p	80.0886	NM_001286060

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Motifs and transcription factors (TFs) regulating RAB30

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB30	transfac_public__M00039	CREB1 (directAnnotation).
RAB30	jaspar__MA0039.4	KLF4 (directAnnotation).
RAB30	transfac_pro__M04746	E2F1 (directAnnotation).
RAB30	metacluster_163.1	KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF1; KLF10; KLF10; KLF12; KLF12; KLF12; KLF13; KLF16; KLF17; KLF2; KLF3; KLF3; KLF3; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF5; KLF6; KLF6; KLF6; KLF7; KLF9; KLF9; SALL4; SP1; ZNF148; ZNF148; ZNF526 (directAnnotation). EGR4; KLF1; KLF1; KLF12; KLF12; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF3; KLF4; KLF4; KLF4; KLF4; KLF4; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF8; KLF9; SP4; SP5; SP5; SP6; SP7; SP8; SP9; ZNF526 (inferredBy_Orthology).
RAB30	tfdimers__MD00457	SREBF1; SREBF2; ZNF354C (directAnnotation).
RAB30	metacluster_34.3	EGR1; ETS1; SETDB1; SIX5; SIX5; ZNF143; ZNF76 (directAnnotation).
RAB30	transfac_pro__M04595	SALL2 (directAnnotation).
RAB30	jaspar__MA1117.1	RELB (directAnnotation).
RAB30	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB30	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB30	jaspar__MA1122.1	TFDP1 (directAnnotation).
RAB30	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
RAB30	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB30	transfac_pro__M02090	E2F4 (directAnnotation).
RAB30	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB30	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
RAB30	transfac_pro__M01303	SP1 (directAnnotation).
RAB30	kznf__ZNF846_Imbeault2017_RP_ChIP-seq	ZNF846 (directAnnotation).
RAB30	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
RAB30	metacluster_163.2	ZNF682 (directAnnotation).
RAB30	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
RAB30	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
RAB30	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RAB30	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB30	transfac_pro__M01150	DMRTA2 (directAnnotation).
RAB30	metacluster_141.4	GLIS2 (directAnnotation).
RAB30	taipale_tf_pairs__ETV2_SOX15_RSCGGAANNNNNNNYWTTGT_CAP_repr	ETV2; SOX15 (directAnnotation).
RAB30	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
RAB30	metacluster_127.3	FOXO1; FOXO3; FOXO4 (directAnnotation).
RAB30	transfac_pro__M06513	ZFP90 (directAnnotation).
RAB30	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
RAB30	transfac_pro__M07447	CARF (directAnnotation).
RAB30	transfac_pro__M02022	MAFK (directAnnotation).
RAB30	metacluster_161.1	HOXA9 (directAnnotation).
RAB30	transfac_pro__M06966	E4F1 (inferredBy_Orthology).
RAB30	transfac_pro__M05519	FEZF2 (inferredBy_Orthology).
RAB30	transfac_pro__M06259	ZNF91 (directAnnotation).
RAB30	transfac_pro__M06180	ZNF445 (directAnnotation).
RAB30	metacluster_160.2	FEZF1; FEZF2 (directAnnotation).
RAB30	transfac_pro__M06115	ZNF28 (directAnnotation).
RAB30	metacluster_140.1	BCL11B; BCL11B (directAnnotation).
RAB30	metacluster_7.7	SP2 (directAnnotation). KLF16 (inferredBy_Orthology).
RAB30	transfac_pro__M05939	ZNF471 (directAnnotation).
RAB30	tfdimers__MD00195	CDX2; FOXG1; FOXO1 (directAnnotation).
RAB30	jaspar__MA1951.1	FOS (directAnnotation).
RAB30	metacluster_180.3	ATF2; ATF2; ATF2; ATF2; ATF3; ATF3; ATF4; ATF4; ATF6; ATF6B; ATF7; ATF7; BACH2; BATF3; BATF3; CREB1; CREB1; CREB3; FOSL1; FOSL2; JDP2; JUN; JUN; JUN; JUND; JUND; XBP1; ZBTB21 (directAnnotation). JDP2; JDP2; JUND (inferredBy_Orthology).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."