Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB21

Summary for RAB21

Gene information	Gene symbol	RAB21
	Ensembl ID	ENSG00000080371
	Entrez ID	23011
	Gene name	RAB21, member RAS oncogene family
	Synonyms	KIAA0118
	Gene type	protein_coding
	UniProtAcc	Q9UL25

Top

Dataset with differentially expressed gene: RAB21

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.39934	1.91e-37
GSE168668	LNCaP cell line	Cell line	Prostate cancer	Prostate cancer	Targeted therapy	enzalutamide	NA	Malignant cells	0.321314	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.280759	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.461363	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.326114	1.20e-21
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	0.267538	0.00e+00

Top

Expression of RAB21 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to RAB21

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating RAB21

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB21	hsa-miR-34a-5p	86.7503	NM_014999
RAB21	hsa-miR-449a	86.7503	NM_014999
RAB21	hsa-miR-4719	86.332	NM_014999
RAB21	hsa-miR-6732-3p	86.2837	NM_014999
RAB21	hsa-miR-5700	86.2055	NM_014999
RAB21	hsa-miR-6780a-5p	86.1673	NM_014999
RAB21	hsa-miR-1226-5p	85.8547	NM_014999
RAB21	hsa-miR-103a-2-5p	85.439	NM_014999
RAB21	hsa-miR-103a-1-5p	85.439	NM_014999
RAB21	hsa-miR-4282	85.2204	NM_014999
RAB21	hsa-miR-379-3p	85.1304	NM_014999
RAB21	hsa-miR-411-3p	85.1304	NM_014999
RAB21	hsa-miR-4465	85.0004	NM_014999
RAB21	hsa-miR-19b-3p	84.5796	NM_014999
RAB21	hsa-miR-19a-3p	84.5796	NM_014999
RAB21	hsa-miR-32-3p	84.5512	NM_014999
RAB21	hsa-miR-1273h-5p	84.3988	NM_014999
RAB21	hsa-miR-30b-3p	84.3988	NM_014999
RAB21	hsa-miR-3689b-3p	84.3988	NM_014999
RAB21	hsa-miR-6779-5p	84.3988	NM_014999
RAB21	hsa-miR-3689a-3p	84.3988	NM_014999
RAB21	hsa-miR-3689c	84.3988	NM_014999
RAB21	hsa-miR-3658	84.0752	NM_014999
RAB21	hsa-miR-15a-3p	83.9984	NM_014999
RAB21	hsa-miR-127-5p	83.9566	NM_014999
RAB21	hsa-miR-3616-3p	83.3717	NM_014999
RAB21	hsa-miR-626	83.3045	NM_014999
RAB21	hsa-miR-6876-3p	83.3045	NM_014999
RAB21	hsa-miR-3074-3p	83.2069	NM_014999
RAB21	hsa-miR-4477a	82.9894	NM_014999
RAB21	hsa-miR-6820-3p	82.79	NM_014999
RAB21	hsa-miR-3164	82.79	NM_014999
RAB21	hsa-miR-3180-5p	82.7304	NM_014999
RAB21	hsa-miR-500a-3p	81.7551	NM_014999
RAB21	hsa-miR-5587-5p	81.7509	NM_014999
RAB21	hsa-miR-4457	81.6244	NM_014999
RAB21	hsa-miR-4676-3p	81.5059	NM_014999
RAB21	hsa-miR-452-5p	81.5059	NM_014999
RAB21	hsa-miR-892c-3p	81.5059	NM_014999
RAB21	hsa-miR-6499-3p	81.3737	NM_014999
RAB21	hsa-miR-10523-5p	81.2126	NM_014999
RAB21	hsa-miR-539-3p	80.1285	NM_014999
RAB21	hsa-miR-485-3p	80.1285	NM_014999

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating RAB21

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB21	taipale_tf_pairs__E2F1_HES7_RRCRCGYGYNNNNSGCGCSN_CAP_repr	E2F1; HES7 (directAnnotation).
RAB21	kznf__ZNF25_Imbeault2017_OM_MEME	ZNF25 (directAnnotation).
RAB21	taipale_tf_pairs__ETV5_HES7_NNCACGTGNNNNCCGGAANN_CAP	ETV5; HES7 (directAnnotation).
RAB21	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAB21	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
RAB21	metacluster_195.2	EGR2; KLF10; KLF10; KLF11; KLF11; KLF11; KLF13; KLF13; KLF13; KLF13; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF15; KLF15; KLF16; KLF3; KLF8; KLF9; KLF9; KLF9; SP1; SP1; SP1; SP3; SP3; SP4; SP8; SP8; SP8; SP9; SP9 (directAnnotation). EGR1; KLF1; KLF12; KLF13; KLF14; KLF14; KLF14; KLF14; KLF14; KLF14; KLF16; KLF17; KLF17; KLF17; KLF17; KLF18; KLF18; KLF18; KLF18; KLF18; KLF18; KLF2; KLF2; KLF2; KLF3; KLF4; KLF5; KLF5; KLF5; KLF6; KLF7; KLF7; KLF8; KLF9; SP1; SP3; SP4; SP4; SP5; SP5; SP5; SP6; SP7; SP8; SP9 (inferredBy_Orthology).
RAB21	metacluster_67.2	ZNF501 (directAnnotation). ACAA1; E2F2; E2F2; E2F3; E2F3; FOXN4 (inferredBy_Orthology).
RAB21	metacluster_3.14	WT1; WT1 (directAnnotation).
RAB21	metacluster_135.11	NR2C2 (directAnnotation).
RAB21	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
RAB21	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
RAB21	metacluster_7.13	ZFX (directAnnotation).
RAB21	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB21	cisbp__M00968	MTF2 (directAnnotation).
RAB21	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB21	metacluster_160.20	JUND; PRDM15 (directAnnotation).
RAB21	cisbp__M00341	PAX6 (directAnnotation).
RAB21	metacluster_198.3	ZFP64 (directAnnotation).
RAB21	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
RAB21	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB21	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB21	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB21	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB21	kznf__ZNF213_Schmitges2016_RCADE	ZNF213 (directAnnotation).
RAB21	metacluster_175.1	ZNF283 (directAnnotation).
RAB21	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB21	transfac_pro__M02844	BCL6B (inferredBy_Orthology).
RAB21	metacluster_125.2	TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; ZNF611; ZNF611 (directAnnotation). TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2A; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2B; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2C; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2D; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E; TFAP2E (inferredBy_Orthology).
RAB21	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
RAB21	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB21	kznf__ZNF682_Isakova2017_SMiLE-seq	ZNF682 (directAnnotation).
RAB21	metacluster_151.2	ZNF23 (directAnnotation).
RAB21	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
RAB21	transfac_pro__M03806	ZBTB7C (directAnnotation).
RAB21	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB21	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
RAB21	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).
RAB21	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
RAB21	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RAB21	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
RAB21	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
RAB21	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB21	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
RAB21	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RAB21	jaspar__MA0748.2	YY2 (directAnnotation).
RAB21	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RAB21	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RAB21	jaspar__MA0604.1	ATF1 (inferredBy_Orthology).
RAB21	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RAB21	transfac_pro__M00430	E2F1 (directAnnotation).

Page: 1 2 3

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."