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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB14

Summary for RAB14

Gene information	Gene symbol	RAB14
	Ensembl ID	ENSG00000119396
	Entrez ID	51552
	Gene name	RAB14, member RAS oncogene family
	Synonyms	FBP\|RAB-14
	Gene type	protein_coding
	UniProtAcc	P61106

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Dataset with differentially expressed gene: RAB14

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD4+ T cells	-0.321093	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	CD8+ T cells	-0.33809	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.282221	5.49e-38
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.404807	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.318247	0.00e+00

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Expression of RAB14 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB14

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Gene symbol	Mechanism
RAB14	Unusual Activation of Pro-survival Pathway

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MicroRNAs (miRNA) regulating RAB14

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB14	hsa-miR-138-2-3p	86.2393	NM_016322
RAB14	hsa-miR-10527-5p	86.0404	NM_016322
RAB14	hsa-let-7f-1-3p	85.9391	NM_016322
RAB14	hsa-let-7a-3p	85.9391	NM_016322
RAB14	hsa-let-7b-3p	85.9391	NM_016322
RAB14	hsa-miR-490-3p	85.3926	NM_016322
RAB14	hsa-miR-649	85.3926	NM_016322
RAB14	hsa-miR-4519	85.2587	NM_016322
RAB14	hsa-miR-498-3p	85.0317	NM_016322
RAB14	hsa-miR-4652-3p	84.4122	NM_016322
RAB14	hsa-miR-4316	83.9416	NM_016322
RAB14	hsa-miR-652-5p	83.2387	NM_016322
RAB14	hsa-let-7a-2-3p	83.2237	NM_016322
RAB14	hsa-let-7g-3p	83.2237	NM_016322
RAB14	hsa-miR-6818-5p	83.1314	NM_016322
RAB14	hsa-miR-1324	83.0268	NM_016322
RAB14	hsa-miR-4704-3p	82.8382	NM_016322
RAB14	hsa-miR-3182	82.7559	NM_016322
RAB14	hsa-miR-19a-3p	82.7186	NM_016322
RAB14	hsa-miR-19b-3p	82.7186	NM_016322
RAB14	hsa-miR-6794-5p	82.6461	NM_016322
RAB14	hsa-miR-4716-3p	82.6461	NM_016322
RAB14	hsa-miR-1253	82.4082	NM_016322
RAB14	hsa-miR-224-3p	82.0665	NM_016322
RAB14	hsa-miR-522-3p	82.0665	NM_016322
RAB14	hsa-miR-223-5p	82.0457	NM_016322
RAB14	hsa-miR-3163	82.0324	NM_016322
RAB14	hsa-miR-4482-5p	81.9078	NM_016322
RAB14	hsa-miR-3130-5p	81.9078	NM_016322
RAB14	hsa-let-7f-2-3p	81.2656	NM_016322
RAB14	hsa-miR-1185-1-3p	81.1549	NM_016322
RAB14	hsa-miR-1185-2-3p	81.1549	NM_016322
RAB14	hsa-miR-1293	81.1515	NM_016322
RAB14	hsa-miR-211-5p	81.1485	NM_016322
RAB14	hsa-miR-204-5p	81.1485	NM_016322
RAB14	hsa-miR-216b-3p	81.0445	NM_016322
RAB14	hsa-miR-148b-3p	80.9128	NM_016322
RAB14	hsa-miR-148a-3p	80.9128	NM_016322
RAB14	hsa-miR-152-3p	80.9128	NM_016322
RAB14	hsa-miR-1827	80.818	NM_016322
RAB14	hsa-miR-302b-5p	80.6099	NM_016322
RAB14	hsa-miR-302d-5p	80.6099	NM_016322
RAB14	hsa-miR-1246	80.2729	NM_016322
RAB14	hsa-miR-4659b-3p	80.2078	NM_016322
RAB14	hsa-miR-4659a-3p	80.2078	NM_016322
RAB14	hsa-miR-513a-5p	80.0614	NM_016322

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Motifs and transcription factors (TFs) regulating RAB14

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB14	hocomoco__TYY2_HUMAN.H11MO.0.D	YY2 (directAnnotation).
RAB14	metacluster_141.6	MZF1; TAF1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZFP42; ZNF597 (directAnnotation). TAF1; TAF1L (inferredBy_Orthology).
RAB14	transfac_pro__M02913	SP140 (inferredBy_Orthology).
RAB14	jaspar__MA0185.1	DEAF1 (inferredBy_Orthology).
RAB14	jaspar__MA0748.2	YY2 (directAnnotation).
RAB14	transfac_pro__M01090	SMAD9 (inferredBy_Orthology).
RAB14	transfac_pro__M01088	DEAF1 (inferredBy_Orthology).
RAB14	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
RAB14	cisbp__M00788	ZFY (inferredBy_Orthology).
RAB14	transfac_pro__M00430	E2F1 (directAnnotation).
RAB14	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
RAB14	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
RAB14	transfac_pro__M04893	TAF1 (directAnnotation).
RAB14	homer__NANTGCSGCA_Zfp57	ZFP57 (directAnnotation).
RAB14	transfac_pro__M01199	TRIM28 (directAnnotation).
RAB14	metacluster_7.13	ZFX (directAnnotation).
RAB14	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
RAB14	transfac_pro__M02865	GMEB1 (inferredBy_Orthology).
RAB14	transfac_pro__M08894	OVOL1; OVOL2 (directAnnotation).
RAB14	hdpi__HIP2	UBE2K (directAnnotation).
RAB14	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
RAB14	hdpi__TIMELESS	TIMELESS (directAnnotation).
RAB14	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RAB14	idmmpmm__Mad	SMAD9 (inferredBy_Orthology).
RAB14	metacluster_191.5	SPDEF (inferredBy_Orthology).
RAB14	taipale_tf_pairs__E2F1_ELK1_SGCGCNNNNNNNNNNCGGAAGN_CAP_repr	E2F1; ELK1 (directAnnotation).
RAB14	transfac_pro__M00938	E2F1 (directAnnotation).
RAB14	transfac_pro__M01238	DEAF1 (inferredBy_Orthology).
RAB14	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
RAB14	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
RAB14	hdpi__RARA	RARA (directAnnotation).
RAB14	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
RAB14	hdpi__ELF2	ELF2 (directAnnotation).
RAB14	taipale_tf_pairs__TFAP2C_DLX3_NSCCNNNRGGCANNNNNNTAATKR_CAP_repr	DLX3; TFAP2C (directAnnotation).
RAB14	taipale_tf_pairs__ERF_PITX1_NSCGGANNNNNNGGMTTA_CAP	ERF; PITX1 (directAnnotation).
RAB14	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
RAB14	jaspar__MA1583.1	ZFP57 (directAnnotation).
RAB14	cisbp__M00968	MTF2 (directAnnotation).
RAB14	transfac_pro__M02898	SMAD3 (directAnnotation).
RAB14	metacluster_61.1	DEAF1; DEAF1 (directAnnotation).
RAB14	hdpi__HTATIP2	HTATIP2 (directAnnotation).
RAB14	jaspar__MA1721.1	ZNF93 (directAnnotation).
RAB14	transfac_pro__M04916	TAF1 (directAnnotation).
RAB14	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
RAB14	jaspar__MA1122.1	TFDP1 (directAnnotation).
RAB14	metacluster_19.6	GMEB1 (directAnnotation). GMEB1 (inferredBy_Orthology).
RAB14	transfac_pro__M07310	SP5 (directAnnotation).
RAB14	cisbp__M01863	ZNF711 (inferredBy_Orthology).
RAB14	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
RAB14	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."