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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: RAB10

Summary for RAB10

Gene information	Gene symbol	RAB10
	Ensembl ID	ENSG00000084733
	Entrez ID	10890
	Gene name	RAB10, member RAS oncogene family
	Synonyms	NA
	Gene type	protein_coding
	UniProtAcc	P61026

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Dataset with differentially expressed gene: RAB10

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.487623	0.00e+00
GSE153697	patients	Bone marrow aspirate	Acute lymphoblastic leukemia	Relapsed B-cell acute lymphoblastic leukemia (B-ALL)	Immunotherapy	anti-CD19 CAR-T	NA	Malignant cells	0.35021	1.56e-22
GSE169246_PacAteBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Immunotherapy	atezolizumab + paclitaxel	post	Mono/Macro	-0.26944	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.353419	0.00e+00
GSE175716	PDX	Tumor tissue	Liver cancer	Advanced hepatocellular carcinoma	Targeted therapy	sorafenib	NA	Malignant cells	-0.413727	9.07e-40

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Expression of RAB10 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to RAB10

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating RAB10

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
RAB10	hsa-miR-2355-3p	87.854	NM_016131
RAB10	hsa-miR-3133	87.7646	NM_016131
RAB10	hsa-miR-2115-5p	87.6137	NM_016131
RAB10	hsa-miR-196a-1-3p	87.4113	NM_016131
RAB10	hsa-miR-6815-5p	87.346	NM_016131
RAB10	hsa-miR-6865-5p	87.346	NM_016131
RAB10	hsa-miR-600	87.2398	NM_016131
RAB10	hsa-miR-6508-5p	87.153	NM_016131
RAB10	hsa-miR-1236-3p	87.1246	NM_016131
RAB10	hsa-miR-4282	86.4742	NM_016131
RAB10	hsa-miR-519d-3p	86.4558	NM_016131
RAB10	hsa-miR-106a-5p	86.4558	NM_016131
RAB10	hsa-miR-20a-5p	86.4558	NM_016131
RAB10	hsa-miR-106b-5p	86.4558	NM_016131
RAB10	hsa-miR-20b-5p	86.4558	NM_016131
RAB10	hsa-miR-17-5p	86.4558	NM_016131
RAB10	hsa-miR-93-5p	86.4558	NM_016131
RAB10	hsa-miR-300	86.33	NM_016131
RAB10	hsa-miR-676-3p	86.1698	NM_016131
RAB10	hsa-miR-1976	86.0275	NM_016131
RAB10	hsa-miR-12133	85.9224	NM_016131
RAB10	hsa-miR-1271-5p	85.9224	NM_016131
RAB10	hsa-miR-7159-3p	85.2732	NM_016131
RAB10	hsa-miR-4717-5p	84.9906	NM_016131
RAB10	hsa-miR-624-5p	84.9262	NM_016131
RAB10	hsa-miR-329-5p	84.7322	NM_016131
RAB10	hsa-miR-8067	84.2697	NM_016131
RAB10	hsa-miR-3677-5p	84.0612	NM_016131
RAB10	hsa-miR-6509-3p	83.9351	NM_016131
RAB10	hsa-miR-1273h-3p	83.7081	NM_016131
RAB10	hsa-miR-7844-5p	83.5134	NM_016131
RAB10	hsa-miR-1284	83.4527	NM_016131
RAB10	hsa-miR-205-3p	83.3409	NM_016131
RAB10	hsa-miR-451b	82.8893	NM_016131
RAB10	hsa-miR-4520-3p	82.859	NM_016131
RAB10	hsa-miR-3161	82.7413	NM_016131
RAB10	hsa-miR-4516	82.5644	NM_016131
RAB10	hsa-miR-6715a-3p	82.3472	NM_016131
RAB10	hsa-miR-622	82.1852	NM_016131
RAB10	hsa-miR-3678-3p	81.6916	NM_016131
RAB10	hsa-miR-1301-3p	81.2614	NM_016131
RAB10	hsa-miR-5047	81.2614	NM_016131
RAB10	hsa-miR-381-3p	80.965	NM_016131
RAB10	hsa-miR-3160-3p	80.791	NM_016131
RAB10	hsa-miR-583	80.7894	NM_016131
RAB10	hsa-miR-3923	80.724	NM_016131
RAB10	hsa-miR-369-3p	80.0835	NM_016131
RAB10	hsa-miR-493-5p	80.0213	NM_016131

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Motifs and transcription factors (TFs) regulating RAB10

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
RAB10	metacluster_34.4	ETS1; ETS1; ETS1; HCFC1; SIX5; SIX5; SIX5; SIX5; SMARCC2; SMARCC2; THAP11; THAP11; ZNF143; ZNF143; ZNF143; ZNF143 (directAnnotation). TBX2; THAP11; THAP11; ZNF143 (inferredBy_Orthology).
RAB10	metacluster_55.3	E2F6; EGR1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; NRF1; ZBTB2; ZSCAN10 (directAnnotation). NFE2L1; NRF1; NRF1; NRF1 (inferredBy_Orthology).
RAB10	transfac_pro__M04950	EGR1 (directAnnotation).
RAB10	transfac_pro__M00652	NRF1 (directAnnotation).
RAB10	swissregulon__hs__ELF2	ELF2 (directAnnotation).
RAB10	taipale_tf_pairs__HOXD12_ELK3_NTTTAYNNCCGGAARNN_CAP_repr	ELK3; HOXD12 (directAnnotation).
RAB10	transfac_pro__M06331	ZNF343 (directAnnotation).
RAB10	hdpi__ZNF304	ZNF304 (directAnnotation).
RAB10	transfac_pro__M00915	TFAP2A; TFAP2B; TFAP2C (directAnnotation).
RAB10	metacluster_19.1	GMEB2; GMEB2; GMEB2 (directAnnotation).
RAB10	kznf__ZNF777_Imbeault2017_RP_ChIP-seq	ZNF777 (directAnnotation).
RAB10	dbtfbs__GMEB2_HepG2_ENCSR745VSQ_merged_N1	GMEB2 (directAnnotation).
RAB10	transfac_pro__M06484	ZNF683 (directAnnotation).
RAB10	metacluster_155.34	PRDM4 (directAnnotation).
RAB10	transfac_pro__M05993	ZNF711 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."