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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: QSER1

Summary for QSER1

Gene information	Gene symbol	QSER1
	Ensembl ID	ENSG00000060749
	Entrez ID	79832
	Gene name	glutamine and serine rich 1
	Synonyms	FLJ21924
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: QSER1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.297586	4.82e-17

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Expression of QSER1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to QSER1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating QSER1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
QSER1	hsa-miR-7108-5p	83.5088	NM_001076786
QSER1	hsa-miR-216b-3p	83.4085	NM_001076786
QSER1	hsa-miR-4261	83.3804	NM_001076786
QSER1	hsa-miR-6755-5p	83.3205	NM_001076786
QSER1	hsa-miR-6841-5p	83.3205	NM_001076786
QSER1	hsa-miR-7856-5p	83.241	NM_001076786
QSER1	hsa-miR-4470	83.2014	NM_001076786
QSER1	hsa-miR-548e-5p	82.4319	NM_001076786
QSER1	hsa-miR-5701	81.8654	NM_001076786
QSER1	hsa-miR-4262	81.7443	NM_001076786
QSER1	hsa-miR-371a-5p	81.4499	NM_001076786
QSER1	hsa-miR-6830-3p	81.2724	NM_001076786
QSER1	hsa-miR-181c-5p	80.7993	NM_001076786
QSER1	hsa-miR-181d-5p	80.7993	NM_001076786
QSER1	hsa-miR-181a-5p	80.7993	NM_001076786
QSER1	hsa-miR-181b-5p	80.7993	NM_001076786
QSER1	hsa-miR-570-3p	80.4971	NM_001076786
QSER1	hsa-miR-372-5p	80.1683	NM_001076786
QSER1	hsa-miR-3662	80.0316	NM_001076786

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Motifs and transcription factors (TFs) regulating QSER1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
QSER1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
QSER1	metacluster_7.5	PLAGL1; PLAGL1 (directAnnotation).
QSER1	metacluster_7.13	ZFX (directAnnotation).
QSER1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
QSER1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
QSER1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
QSER1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
QSER1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
QSER1	cisbp__M00249	WT1 (directAnnotation).
QSER1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
QSER1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
QSER1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
QSER1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
QSER1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
QSER1	taipale_cyt_meth__KLF12_NGCCGACGCCCW_FL_meth_repr	KLF12 (directAnnotation).
QSER1	transfac_pro__M05432	ZSCAN18 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."