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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PURB

Summary for PURB

Gene information	Gene symbol	PURB
	Ensembl ID	ENSG00000146676
	Entrez ID	5814
	Gene name	purine rich element binding protein B
	Synonyms	PURBETA
	Gene type	protein_coding
	UniProtAcc	Q96QR8

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Dataset with differentially expressed gene: PURB

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE131984_JQ1Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	JQ1 + palbociclib	NA	Malignant cells	0.504527	1.36e-39

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Expression of PURB in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PURB

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PURB

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PURB	hsa-miR-450b-5p	88.2664	NM_033224
PURB	hsa-miR-590-3p	87.3709	NM_033224
PURB	hsa-miR-7845-5p	87.0828	NM_033224
PURB	hsa-miR-8068	86.9723	NM_033224
PURB	hsa-miR-2052	86.719	NM_033224
PURB	hsa-miR-12124	86.4386	NM_033224
PURB	hsa-miR-3689d	86.1065	NM_033224
PURB	hsa-miR-6851-5p	86.1065	NM_033224
PURB	hsa-miR-539-5p	85.8275	NM_033224
PURB	hsa-miR-5585-5p	85.5592	NM_033224
PURB	hsa-miR-4262	85.2453	NM_033224
PURB	hsa-miR-624-5p	84.8629	NM_033224
PURB	hsa-miR-103a-3p	84.4191	NM_033224
PURB	hsa-miR-107	84.4191	NM_033224
PURB	hsa-miR-504-3p	84.1018	NM_033224
PURB	hsa-miR-548aw	84.0367	NM_033224
PURB	hsa-miR-653-5p	84.0276	NM_033224
PURB	hsa-miR-9-3p	83.7781	NM_033224
PURB	hsa-miR-891b	83.6812	NM_033224
PURB	hsa-miR-19b-2-5p	83.4174	NM_033224
PURB	hsa-miR-19b-1-5p	83.4174	NM_033224
PURB	hsa-miR-19a-5p	83.4174	NM_033224
PURB	hsa-miR-493-5p	83.4146	NM_033224
PURB	hsa-miR-545-3p	82.8734	NM_033224
PURB	hsa-miR-1294	82.8271	NM_033224
PURB	hsa-miR-9986	82.8271	NM_033224
PURB	hsa-miR-1283	82.4114	NM_033224
PURB	hsa-miR-5581-3p	82.1242	NM_033224
PURB	hsa-miR-2117	82.1167	NM_033224
PURB	hsa-miR-144-3p	81.9465	NM_033224
PURB	hsa-miR-548l	81.8736	NM_033224
PURB	hsa-miR-520e-5p	81.7331	NM_033224
PURB	hsa-miR-153-5p	80.9916	NM_033224
PURB	hsa-miR-3646	80.6742	NM_033224
PURB	hsa-miR-6529-5p	80.3992	NM_033224
PURB	hsa-miR-5692a	80.3708	NM_033224
PURB	hsa-miR-370-5p	80.2883	NM_033224
PURB	hsa-miR-149-5p	80.0008	NM_033224

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Motifs and transcription factors (TFs) regulating PURB

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PURB	hdpi__NFIX	NFIX (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."