Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PUM1

Summary for PUM1

Gene information	Gene symbol	PUM1
	Ensembl ID	ENSG00000134644
	Entrez ID	9698
	Gene name	pumilio RNA binding family member 1
	Synonyms	KIAA0099\|PUMH1
	Gene type	protein_coding
	UniProtAcc	NA

Top

Dataset with differentially expressed gene: PUM1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE186960	Panc1 cell line	Cell line	Pancreatic cancer	Pancreatic ductal adenocarcinoma (PDAC)	Chemotherapy	gemcitabine	NA	Malignant cells	0.495719	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	0.329962	1.22e-41
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	-0.414509	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	Malignant cells	-0.269251	0.00e+00

Top

Expression of PUM1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PUM1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PUM1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PUM1	hsa-miR-142-3p	83.778	NM_001020658
PUM1	hsa-miR-765	83.7294	NM_001020658
PUM1	hsa-miR-1252-3p	83.4916	NM_001020658
PUM1	hsa-miR-760	83.4736	NM_001020658
PUM1	hsa-miR-6882-5p	82.9584	NM_001020658
PUM1	hsa-miR-1303	82.923	NM_001020658
PUM1	hsa-miR-8063	82.4963	NM_001020658
PUM1	hsa-miR-519e-5p	82.2667	NM_001020658
PUM1	hsa-miR-515-5p	82.2667	NM_001020658
PUM1	hsa-miR-2682-5p	81.8954	NM_001020658
PUM1	hsa-miR-4528	81.779	NM_001020658
PUM1	hsa-miR-4725-3p	81.2806	NM_001020658
PUM1	hsa-miR-6780b-5p	81.2806	NM_001020658
PUM1	hsa-miR-493-5p	81.1322	NM_001020658
PUM1	hsa-miR-4262	81.0927	NM_001020658
PUM1	hsa-miR-3672	80.7691	NM_001020658
PUM1	hsa-miR-6864-3p	80.7691	NM_001020658
PUM1	hsa-miR-9983-3p	80.6289	NM_001020658
PUM1	hsa-miR-567	80.6224	NM_001020658

Page: 1 2

Top

Motifs and transcription factors (TFs) regulating PUM1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PUM1	transfac_pro__M07436	WT1 (directAnnotation).
PUM1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PUM1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PUM1	transfac_pro__M02089	E2F3 (directAnnotation).
PUM1	kznf__ZNF90_Imbeault2017_OM_RCADE	ZNF90 (directAnnotation).
PUM1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PUM1	transfac_pro__M00803	E2F1; E2F3; E2F4; TFDP1 (directAnnotation).
PUM1	transfac_pro__M08819	KLF2 (directAnnotation).
PUM1	transfac_pro__M01175	ZBTB7B (directAnnotation).
PUM1	transfac_pro__M01118	WT1 (directAnnotation).
PUM1	swissregulon__hs__KLF6	KLF6 (directAnnotation).
PUM1	transfac_pro__M01303	SP1 (directAnnotation).
PUM1	transfac_pro__M00716	ZBTB14 (directAnnotation).
PUM1	metacluster_133.2	CPSF4; CPSF4; E2F4; FOXO3; KLF13; KLF15; KLF17; KLF5; MAZ; MAZ; MAZ; MZF1; PATZ1; PATZ1; PATZ1; PATZ1; PLAG1; PRDM9; SP4; VEZF1; WT1; ZBTB17; ZBTB7A; ZBTB7A; ZBTB7B; ZNF148; ZNF148; ZNF148; ZNF148; ZNF180; ZNF180; ZNF202; ZNF219; ZNF219; ZNF263; ZNF263; ZNF28; ZNF281; ZNF281; ZNF281; ZNF281; ZNF281; ZNF383; ZNF398; ZNF398; ZNF444; ZNF444; ZNF467; ZNF543; ZNF543; ZNF641; ZNF692; ZNF737; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF740; ZNF880; ZNF880 (directAnnotation). MAZ; PLAG1; PLAGL1; SP1; SP5; SP5; ZBTB17; ZNF281; ZNF281; ZNF281; ZNF641; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PUM1	transfac_pro__M07397	ZNF148 (directAnnotation).
PUM1	transfac_pro__M12686	ZBTB10 (directAnnotation).
PUM1	transfac_pro__M00807	EGR1; EGR2; EGR3 (directAnnotation).
PUM1	transfac_pro__M01104	OVOL2 (directAnnotation).
PUM1	transfac_pro__M00986	CHURC1 (directAnnotation).
PUM1	metacluster_144.8	ZNF30; ZNF30 (directAnnotation).
PUM1	transfac_pro__M04918	EGR1 (directAnnotation).
PUM1	metacluster_7.13	ZFX (directAnnotation).
PUM1	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PUM1	tfdimers__MD00154	MZF1; SREBF1 (directAnnotation).
PUM1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PUM1	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PUM1	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PUM1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PUM1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PUM1	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).
PUM1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PUM1	kznf__ZFP57_Imbeault2017_RP_ChIP-seq	ZFP57 (directAnnotation).
PUM1	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PUM1	jaspar__MA1721.1	ZNF93 (directAnnotation).
PUM1	metacluster_151.2	ZNF23 (directAnnotation).
PUM1	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PUM1	kznf__ZNF548_Imbeault2017_RP_RCADE	ZNF548 (directAnnotation).
PUM1	transfac_pro__M01199	TRIM28 (directAnnotation).
PUM1	metacluster_133.1	ZNF304; ZNF304; ZSCAN22 (directAnnotation).
PUM1	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PUM1	taipale_tf_pairs__ETV5_HES7_CCGGAANNNNNNCACGTG_CAP	ETV5; HES7 (directAnnotation).
PUM1	transfac_pro__M01253	CNOT3 (directAnnotation).
PUM1	flyfactorsurvey__Mad_FlyReg_FBgn0011648	SMAD9 (inferredBy_Orthology).
PUM1	dbtfbs__ZNF407_representative_N1	ZNF407 (directAnnotation).
PUM1	metacluster_144.5	ZNF610; ZNF610; ZNF610 (directAnnotation).
PUM1	taipale_cyt_meth__ZBTB37_NYACCGCRNNYACCGYR_eDBD_meth_repr	ZBTB37 (directAnnotation).
PUM1	taipale_tf_pairs__TFAP2C_E2F8_NNTCCCGCNNNCCNNNGGC_CAP_repr	E2F8; TFAP2C (directAnnotation).
PUM1	cisbp__M00968	MTF2 (directAnnotation).
PUM1	jaspar__MA0748.2	YY2 (directAnnotation).
PUM1	metacluster_160.20	JUND; PRDM15 (directAnnotation).

Page: 1 2

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."