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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTPRJ

Summary for PTPRJ

Gene information	Gene symbol	PTPRJ
	Ensembl ID	ENSG00000149177
	Entrez ID	5795
	Gene name	protein tyrosine phosphatase receptor type J
	Synonyms	CD148\|DEP1\|HPTPeta
	Gene type	protein_coding
	UniProtAcc	NA

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Dataset with differentially expressed gene: PTPRJ

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE164551	patients	Bone marrow aspirate	Multiple myeloma	Refractory multiple myeloma (MM)	Immunotherapy	CAR-T	NA	CD8+ T cells	0.280164	1.98e-05
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	NK cells	-0.27471	1.32e-39

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Expression of PTPRJ in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTPRJ

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTPRJ

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTPRJ	hsa-miR-19b-1-5p	87.5204	NM_002843
PTPRJ	hsa-miR-19a-5p	87.5204	NM_002843
PTPRJ	hsa-miR-19b-2-5p	87.5204	NM_002843
PTPRJ	hsa-miR-365a-3p	87.4722	NM_002843
PTPRJ	hsa-miR-365b-3p	87.4722	NM_002843
PTPRJ	hsa-miR-3919	87.4412	NM_001098503
PTPRJ	hsa-miR-211-5p	87.3166	NM_002843
PTPRJ	hsa-miR-204-5p	87.3166	NM_002843
PTPRJ	hsa-miR-548an	87.2955	NM_002843
PTPRJ	hsa-miR-3085-3p	87.1356	NM_002843
PTPRJ	hsa-miR-3064-5p	87.1356	NM_002843
PTPRJ	hsa-miR-6504-5p	87.1356	NM_002843
PTPRJ	hsa-miR-4507	87.1064	NM_002843
PTPRJ	hsa-miR-3940-5p	87.1064	NM_002843
PTPRJ	hsa-miR-1257	85.5523	NM_002843
PTPRJ	hsa-miR-3614-3p	85.3007	NM_001098503
PTPRJ	hsa-miR-5692a	84.955	NM_002843
PTPRJ	hsa-miR-9500	84.9064	NM_002843
PTPRJ	hsa-miR-5680	84.8078	NM_002843
PTPRJ	hsa-miR-4323	84.3048	NM_002843
PTPRJ	hsa-miR-153-5p	84.2302	NM_002843
PTPRJ	hsa-miR-4668-5p	84.1832	NM_002843
PTPRJ	hsa-miR-155-5p	83.888	NM_002843
PTPRJ	hsa-miR-329-3p	83.5959	NM_002843
PTPRJ	hsa-miR-362-3p	83.5959	NM_002843
PTPRJ	hsa-miR-4307	83.3462	NM_001098503
PTPRJ	hsa-miR-221-5p	82.2468	NM_002843
PTPRJ	hsa-miR-8073	82.2468	NM_002843
PTPRJ	hsa-miR-10399-5p	81.9791	NM_002843
PTPRJ	hsa-miR-6504-3p	81.9791	NM_002843
PTPRJ	hsa-miR-5584-5p	81.9004	NM_002843
PTPRJ	hsa-miR-6832-3p	81.6059	NM_002843
PTPRJ	hsa-miR-6749-3p	81.3401	NM_002843
PTPRJ	hsa-miR-548az-5p	81.0466	NM_002843
PTPRJ	hsa-miR-548t-5p	81.0466	NM_002843
PTPRJ	hsa-miR-7974	80.9528	NM_001098503
PTPRJ	hsa-miR-8485	80.8361	NM_002843
PTPRJ	hsa-miR-6501-5p	80.5616	NM_002843
PTPRJ	hsa-miR-1304-5p	80.4998	NM_002843

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Motifs and transcription factors (TFs) regulating PTPRJ

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTPRJ	taipale_tf_pairs__ERF_FOXI1_RSCGGATGTTKWN_CAP_repr	ERF; FOXI1 (directAnnotation).
PTPRJ	transfac_pro__M04861	SIX5 (directAnnotation).
PTPRJ	transfac_pro__M04826	EP300 (directAnnotation).
PTPRJ	metacluster_172.23	ZBTB32; ZBTB32 (directAnnotation).
PTPRJ	hdpi__FLI1	FLI1 (directAnnotation).
PTPRJ	metacluster_7.13	ZFX (directAnnotation).
PTPRJ	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PTPRJ	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PTPRJ	metacluster_182.10	ZFX (directAnnotation).
PTPRJ	cisbp__M00788	ZFY (inferredBy_Orthology).
PTPRJ	metacluster_138.2	ELF1; ELF2; ELF4; ELK1; ELK1; ELK1; ELK1; ELK3; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ELK4; ERF; ERG; ERG; ERG; ERG; ETS1; ETS1; ETS2; ETS2; ETV1; ETV1; ETV1; ETV2; ETV3; ETV4; ETV5; ETV5; FEV; FLI1; FLI1; GABPA; GABPA; KMT2B; SPDEF; SPDEF; SPDEF; ZBTB11; ZNF518A; ZNF580 (directAnnotation). ELF1; ELF2; ELF4; ELK1; ELK1; ELK3; ELK4; ERG; ETS1; ETS2; ETV1; ETV2; ETV3; ETV4; ETV5; FEV; FLI1; FLI1; GABPA; SPDEF; SPDEF (inferredBy_Orthology).
PTPRJ	kznf__ZNF100_Imbeault2017_RP_RCADE	ZNF100 (directAnnotation).
PTPRJ	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PTPRJ	metacluster_191.5	SPDEF (inferredBy_Orthology).
PTPRJ	metacluster_126.3	LIN28B; LIN28B (directAnnotation).
PTPRJ	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PTPRJ	metacluster_151.1	KAT7; PML; SMAD5; TAF1; ZFP37; ZGPAT; ZNF519; ZNF519; ZNF571; ZNF770; ZNF770; ZNF770; ZSCAN22; ZSCAN22 (directAnnotation).
PTPRJ	dbtfbs__ZSCAN30_HEK293_ENCSR768VNZ_merged_N1	ZSCAN30 (directAnnotation).
PTPRJ	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PTPRJ	transfac_pro__M01199	TRIM28 (directAnnotation).
PTPRJ	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PTPRJ	hdpi__ELF2	ELF2 (directAnnotation).
PTPRJ	kznf__ZNF571_Imbeault2017_OM_RCADE	ZNF571 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."