Home

Download

Statistics

Landscape

Help

Contact

	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTPRG

Summary for PTPRG

Gene information	Gene symbol	PTPRG
	Ensembl ID	ENSG00000144724
	Entrez ID	5793
	Gene name	protein tyrosine phosphatase receptor type G
	Synonyms	PTPG\|RPTPG
	Gene type	protein_coding
	UniProtAcc	P23470

Top

Dataset with differentially expressed gene: PTPRG

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.272335	2.55e-31
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.322294	0.00e+00

Top

Expression of PTPRG in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

Top

Significant ligand-receptor pairs related to PTPRG

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

Top

Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

Top

MicroRNAs (miRNA) regulating PTPRG

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTPRG	hsa-miR-519e-3p	92.7133	NM_002841
PTPRG	hsa-miR-515-3p	92.7133	NM_002841
PTPRG	hsa-miR-4302	92.3726	NM_002841
PTPRG	hsa-miR-6768-3p	92.2226	NM_002841
PTPRG	hsa-miR-6779-3p	92.1365	NM_002841
PTPRG	hsa-miR-1323	92.1152	NM_002841
PTPRG	hsa-miR-196b-5p	91.1236	NM_002841
PTPRG	hsa-miR-196a-5p	91.1236	NM_002841
PTPRG	hsa-miR-641	91.0545	NM_002841
PTPRG	hsa-miR-3617-5p	91.0545	NM_002841
PTPRG	hsa-miR-1-3p	90.8623	NM_002841
PTPRG	hsa-miR-206	90.8623	NM_002841
PTPRG	hsa-miR-4670-3p	90.611	NM_002841
PTPRG	hsa-miR-6777-3p	90.5876	NM_002841
PTPRG	hsa-miR-1208	90.2166	NM_002841
PTPRG	hsa-miR-520d-5p	90.2153	NM_002841
PTPRG	hsa-miR-7158-3p	89.8672	NM_002841
PTPRG	hsa-miR-449c-5p	89.7607	NM_002841
PTPRG	hsa-miR-34b-5p	89.7607	NM_002841
PTPRG	hsa-miR-548o-3p	89.7028	NM_002841
PTPRG	hsa-miR-33b-3p	88.6031	NM_002841
PTPRG	hsa-miR-4703-5p	88.2709	NM_002841
PTPRG	hsa-miR-3942-5p	88.2709	NM_002841
PTPRG	hsa-miR-613	88.2139	NM_002841
PTPRG	hsa-miR-181b-2-3p	88.0507	NM_002841
PTPRG	hsa-miR-181b-3p	88.0507	NM_002841
PTPRG	hsa-miR-653-3p	87.8494	NM_002841
PTPRG	hsa-miR-2682-5p	87.2998	NM_002841
PTPRG	hsa-miR-6894-3p	86.111	NM_002841
PTPRG	hsa-miR-6854-3p	85.973	NM_002841
PTPRG	hsa-miR-3128	85.8782	NM_002841
PTPRG	hsa-miR-4671-3p	85.6209	NM_002841
PTPRG	hsa-miR-580-5p	85.576	NM_002841
PTPRG	hsa-miR-524-5p	85.0794	NM_002841
PTPRG	hsa-miR-374a-3p	85.0077	NM_002841
PTPRG	hsa-miR-4264	84.4807	NM_002841
PTPRG	hsa-miR-4420	84.3375	NM_002841
PTPRG	hsa-miR-562	84.1835	NM_002841
PTPRG	hsa-miR-605-3p	83.8224	NM_002841
PTPRG	hsa-miR-153-5p	83.5854	NM_002841
PTPRG	hsa-miR-5582-3p	83.2859	NM_002841
PTPRG	hsa-miR-215-3p	83.0288	NM_002841
PTPRG	hsa-miR-1233-5p	82.6313	NM_002841
PTPRG	hsa-miR-6778-5p	82.6313	NM_002841
PTPRG	hsa-miR-3613-3p	82.5757	NM_002841
PTPRG	hsa-miR-4469	82.5344	NM_002841
PTPRG	hsa-miR-1294	82.3201	NM_002841
PTPRG	hsa-miR-9986	82.3201	NM_002841
PTPRG	hsa-miR-642a-3p	81.9709	NM_002841
PTPRG	hsa-miR-642b-3p	81.9709	NM_002841

Page: 1 2 3

Top

Motifs and transcription factors (TFs) regulating PTPRG

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTPRG	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PTPRG	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PTPRG	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).

Page: 1

Top

Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

Top

Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."