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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PTGFRN

Summary for PTGFRN

Gene information	Gene symbol	PTGFRN
	Ensembl ID	ENSG00000134247
	Entrez ID	5738
	Gene name	prostaglandin F2 receptor inhibitor
	Synonyms	CD315\|CD9P-1\|EWI-F\|FLJ11001\|FPRP\|KIAA1436\|SMAP-6
	Gene type	protein_coding
	UniProtAcc	Q9P2B2

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Dataset with differentially expressed gene: PTGFRN

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE140440	DU145 and PC cell lines	Cell line	Prostate cancer	Prostate cancer	Chemotherapy	docetaxel	NA	Malignant cells	2.94297	2.08e-13
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	0.291387	3.28e-19
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	-0.427251	0.00e+00
GSE164897_VemTra	A375 cell line	Cell line	Melanoma	B+E2:E57RAFV600E-mutant melanoma	Targeted therapy	vemurafenib + trametinib	NA	Malignant cells	0.427894	0.00e+00

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Expression of PTGFRN in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PTGFRN

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PTGFRN

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PTGFRN	hsa-miR-548ay-5p	88.5491	NM_020440
PTGFRN	hsa-miR-548am-5p	88.5491	NM_020440
PTGFRN	hsa-miR-548as-5p	88.5491	NM_020440
PTGFRN	hsa-miR-548bb-5p	88.5491	NM_020440
PTGFRN	hsa-miR-298	88.2998	NM_020440
PTGFRN	hsa-miR-4735-3p	88.281	NM_020440
PTGFRN	hsa-miR-3167	88.108	NM_020440
PTGFRN	hsa-miR-6772-3p	88.049	NM_020440
PTGFRN	hsa-miR-7855-5p	87.8659	NM_020440
PTGFRN	hsa-miR-10527-5p	87.181	NM_020440
PTGFRN	hsa-miR-4254	87.1675	NM_020440
PTGFRN	hsa-miR-92a-2-5p	86.6118	NM_020440
PTGFRN	hsa-miR-562	86.2734	NM_020440
PTGFRN	hsa-miR-1227-3p	86.1949	NM_020440
PTGFRN	hsa-miR-5002-5p	86.1252	NM_020440
PTGFRN	hsa-miR-4710	85.7075	NM_020440
PTGFRN	hsa-miR-4687-3p	85.6987	NM_020440
PTGFRN	hsa-miR-4801	85.3192	NM_020440
PTGFRN	hsa-miR-6810-3p	85.2873	NM_020440
PTGFRN	hsa-miR-6847-5p	85.0899	NM_020440
PTGFRN	hsa-miR-345-3p	84.9618	NM_020440
PTGFRN	hsa-miR-6801-3p	84.8446	NM_020440
PTGFRN	hsa-miR-4660	84.4486	NM_020440
PTGFRN	hsa-miR-133a-5p	84.3751	NM_020440
PTGFRN	hsa-miR-6875-3p	83.7691	NM_020440
PTGFRN	hsa-miR-4251	83.7157	NM_020440
PTGFRN	hsa-miR-1304-3p	83.3658	NM_020440
PTGFRN	hsa-miR-570-3p	82.8634	NM_020440
PTGFRN	hsa-miR-6771-3p	82.6856	NM_020440
PTGFRN	hsa-miR-6852-3p	82.4419	NM_020440
PTGFRN	hsa-miR-320a-3p	82.3607	NM_020440
PTGFRN	hsa-miR-4429	82.3607	NM_020440
PTGFRN	hsa-miR-320b	82.3607	NM_020440
PTGFRN	hsa-miR-320d	82.3607	NM_020440
PTGFRN	hsa-miR-320c	82.3607	NM_020440
PTGFRN	hsa-miR-6780a-3p	82.3144	NM_020440
PTGFRN	hsa-miR-3974	81.6489	NM_020440
PTGFRN	hsa-miR-6881-3p	80.7595	NM_020440
PTGFRN	hsa-miR-153-5p	80.0903	NM_020440

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Motifs and transcription factors (TFs) regulating PTGFRN

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PTGFRN	metacluster_7.13	ZFX (directAnnotation).
PTGFRN	cisbp__M01863	ZNF711 (inferredBy_Orthology).
PTGFRN	metacluster_151.2	ZNF23 (directAnnotation).
PTGFRN	metacluster_155.23	BCL11B; ZNF711; ZNF711 (directAnnotation). ZFY (inferredBy_Orthology).
PTGFRN	kznf__ZNF783_Imbeault2017_OM_MEME	ZNF783 (directAnnotation).
PTGFRN	metacluster_144.3	ZNF704; ZNF704 (directAnnotation).
PTGFRN	hdpi__ETV4	ETV4 (directAnnotation).
PTGFRN	metacluster_135.10	MBD2; MBD2; MECP2; MECP2 (directAnnotation).
PTGFRN	kznf__ZBTB14_Schmitges2016_RCADE	ZBTB14 (directAnnotation).
PTGFRN	taipale_cyt_meth__E2F2_NCGCGCGCGCM_eDBD_meth	E2F2 (directAnnotation).
PTGFRN	transfac_pro__M00716	ZBTB14 (directAnnotation).
PTGFRN	kznf__ZNF441_Imbeault2017_RP_RCADE	ZNF441 (directAnnotation).
PTGFRN	hocomoco__PATZ1_HUMAN.H11MO.1.C	PATZ1 (directAnnotation).
PTGFRN	transfac_pro__M06135	ZNF28 (directAnnotation).
PTGFRN	taipale_tf_pairs__ETV5_HOXA2_RSCGGWAATKR_CAP	ETV5; HOXA2 (directAnnotation).
PTGFRN	cisbp__M02645	ETS1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."