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	Gene summary
	Datasets with differential expression of this gene
	Expression of this gene in the resistant group across all datasets and cell types
	Significant ligand-receptor pairs related to this gene (This gene does not contain this module)
	Known drug resistance mechanisms of this gene (This gene does not contain this module)
	MicroRNAs (miRNAs) regulating this gene
	Motifs and transcription factors (TFs) regulating this gene
	Acts as a transcription factor (This gene does not contain this module)
	Acts as a drug target< (This gene does not contain this module)

Gene: PSIP1

Summary for PSIP1

Gene information	Gene symbol	PSIP1
	Ensembl ID	ENSG00000164985
	Entrez ID	11168
	Gene name	PC4 and SFRS1 interacting protein 1
	Synonyms	DFS70\|LEDGF\|p52\|p75\|PSIP2
	Gene type	protein_coding
	UniProtAcc	O75475

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Dataset with differentially expressed gene: PSIP1

Differentially expression genes between the resistant and sensitive groups. A positive avg_log2FC represents significantly high expression in the resistant group, while a negative avg_log2FC represents significantly low expression in the resistant group.

Dataset	Source	Tissue	Cancer type level1	Cancer type level2	Drug type	Regimen	Timepoint	Cell type	avg_log2FC	p_val_adj
GSE138267	CDX	Tumor tissue	Lung cancer	Small cell lung cancer (SCLC)	Chemotherapy	NA	NA	Malignant cells	0.487809	0.00e+00
GSE163836	FCIBC02 cell line	Cell line	Breast cancer	Inflammatory breast cancer	Chemotherapy	paclitaxel	NA	Malignant cells	-0.438476	0.00e+00
GSE169246_PacBlood	patients	Peripheral blood mononuclear cells	Breast cancer	Advanced triple-negative breast cancer (TNBC)	Chemotherapy	paclitaxel	pre	CD4+ T cells	0.32958	0.00e+00
GSE189460	patients	Bone marrow aspirate	Multiple myeloma	Multiple myeloma (MM)	Targeted therapy	bortezomib + melphalan + prednisolone	pre	Malignant cells	0.459502	0.00e+00
GSE158457	PDX cells	Cell line	Acute lymphoblastic leukemia	T-cell acute lymphoblastic leukemia (ALL)	Targeted therapy	dasatinib	NA	Malignant cells	-0.269556	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Erythrocytes	-0.436786	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	post	Malignant cells	0.34129	0.00e+00
GSE199333	patients	Bone marrow aspirate	Acute myeloid leukemia	Primary FLT3-ITD-mutated acute myeloid leukemia (AML)	Targeted therapy	gilteritinib	pre	B cells	-0.553367	3.92e-02
GSE111014	patients	Peripheral blood mononuclear cells	Chronic lymphocytic leukemia	Chronic lymphocytic leukemia (CLL)	Targeted therapy	ibrutinib	pre	CD4+ T cells	-0.344676	9.92e-04
GSE131984_Pal	SUM159 cell line	Cell line	Breast cancer	Triple-negative breast cancer (TNBC)	Targeted therapy	palbociclib	NA	Malignant cells	-0.332298	3.29e-12
GSE108397	451Lu cell line	Cell line	Melanoma	Melanoma	Targeted therapy	PLX-4720	NA	Malignant cells	0.296888	2.69e-42
GSE115251	Kelly cell line	Cell line	Neuroblastoma	Neuroblastoma	Targeted therapy	TAE684	NA	Malignant cells	-0.574585	0.00e+00

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Expression of PSIP1 in the resistant group across all datasets and cell types

Red dots represent significantly high expression in the resistant group, while blue dots represent significantly low expression in the resistant group. White dots represent that there is no significant difference in the expression of this gene between the resistant and sensitive groups. Blank represents that this cell type is not present in this dataset. (If the image exists, the user can click on it to enlarge it in a new window.)

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Significant ligand-receptor pairs related to PSIP1

This table shows the significant ligand-receptor pairs related to this gene across all datasets, timepoints and conditions. (Complete files can be downloaded from the download section.)

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Known drug resistance mechanisms of this gene

This table shows the known drug resistance mechanisms of this gene. Clicking on this gene will link to another database that displays more drug resistance-related information.

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MicroRNAs (miRNA) regulating PSIP1

This table shows the miRNAs with a score of more than 80 regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	miRNA	Score	GeneBank accession
PSIP1	hsa-miR-6816-3p	86.9706	NM_001128217
PSIP1	hsa-miR-340-5p	86.576	NM_001128217
PSIP1	hsa-miR-4672	86.5592	NM_001128217
PSIP1	hsa-miR-4724-3p	86.496	NM_001128217
PSIP1	hsa-miR-381-3p	86.1644	NM_001128217
PSIP1	hsa-miR-300	86.1644	NM_001128217
PSIP1	hsa-miR-30d-3p	86.1284	NM_001128217
PSIP1	hsa-miR-30a-3p	86.1284	NM_001128217
PSIP1	hsa-miR-30e-3p	86.1284	NM_001128217
PSIP1	hsa-miR-548ac	85.9319	NM_001128217
PSIP1	hsa-miR-548bb-3p	85.9319	NM_001128217
PSIP1	hsa-miR-548z	85.9319	NM_001128217
PSIP1	hsa-miR-548d-3p	85.9319	NM_001128217
PSIP1	hsa-miR-548h-3p	85.9319	NM_001128217
PSIP1	hsa-miR-3163	85.8075	NM_001128217
PSIP1	hsa-miR-33a-3p	85.7051	NM_001128217
PSIP1	hsa-miR-548ar-3p	85.7016	NM_001128217
PSIP1	hsa-miR-455-3p	85.4107	NM_021144
PSIP1	hsa-miR-135a-5p	85.2851	NM_001128217
PSIP1	hsa-miR-135b-5p	85.2851	NM_001128217
PSIP1	hsa-miR-4666a-3p	84.5229	NM_001317898
PSIP1	hsa-miR-1231	84.1447	NM_001128217
PSIP1	hsa-miR-155-5p	83.7675	NM_021144
PSIP1	hsa-miR-4477a	83.4402	NM_021144
PSIP1	hsa-miR-302c-5p	82.801	NM_001128217
PSIP1	hsa-miR-5002-5p	82.6254	NM_001128217
PSIP1	hsa-miR-376a-2-5p	82.5009	NM_001317898
PSIP1	hsa-miR-548a-3p	82.3532	NM_001128217
PSIP1	hsa-miR-548bc	82.3532	NM_001128217
PSIP1	hsa-miR-548az-3p	82.3532	NM_001128217
PSIP1	hsa-miR-548e-3p	82.3532	NM_001128217
PSIP1	hsa-miR-548f-3p	82.3532	NM_001128217
PSIP1	hsa-miR-4469	81.0657	NM_001128217
PSIP1	hsa-miR-337-3p	80.8131	NM_001128217
PSIP1	hsa-miR-410-3p	80.7239	NM_001128217
PSIP1	hsa-miR-524-5p	80.0335	NM_001128217
PSIP1	hsa-miR-520d-5p	80.0335	NM_001128217

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Motifs and transcription factors (TFs) regulating PSIP1

This table shows the Motifs and transcription factors (TFs) regulating this gene. (Complete files can be downloaded from the download section.)

Gene symbol	motif	TF_highConf
PSIP1	hdpi__ETV4	ETV4 (directAnnotation).
PSIP1	taipale_tf_pairs__ELK1_TEF_NSCGGAWNTTACGTAAN_CAP	ELK1; TEF (directAnnotation).
PSIP1	taipale_tf_pairs__HOXB2_ELK3_RSCGGAAGTMRTTA_CAP	ELK3; HOXB2 (directAnnotation).
PSIP1	taipale_tf_pairs__ERF_HES7_NCCGGAANNNNNNCACGYGNN_CAP_repr	ERF; HES7 (directAnnotation).
PSIP1	metacluster_19.7	GMEB1; GMEB2 (inferredBy_Orthology).
PSIP1	taipale_tf_pairs__GCM1_SPDEF_RTGNKGGCGGAWG_CAP_repr	GCM1; SPDEF (directAnnotation).
PSIP1	transfac_pro__M01219	SP1 (directAnnotation). SP3 (inferredBy_Orthology).
PSIP1	transfac_pro__M07397	ZNF148 (directAnnotation).
PSIP1	metacluster_131.7	EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; EGR3; EGR3; EGR3; EGR3; EGR4; EGR4; WT1 (directAnnotation). EGR1; EGR1; EGR1; EGR1; EGR1; EGR2; EGR2; EGR2; EGR2; EGR2; EGR3; EGR3; WT1; ZBTB43; ZBTB43; ZBTB43; ZBTB43; ZBTB5; ZBTB5; ZBTB5; ZBTB5; ZBTB7A; ZBTB7A; ZBTB7A; ZBTB7A; ZNF367; ZNF367; ZNF367; ZNF367; ZNF740; ZNF740; ZNF740; ZNF740 (inferredBy_Orthology).
PSIP1	metacluster_131.4	EGR2; EGR2; ZFHX2; ZNF141 (directAnnotation).
PSIP1	taipale_cyt_meth__ZNF281_NCCCCTCCCCCN_eDBD_meth	ZNF281 (directAnnotation).
PSIP1	metacluster_15.2	E2F1; E2F1; E2F1; E2F1; E2F1; E2F3; E2F4; E2F4; E2F4; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F6; E2F7; TFDP1; TFDP2; ZNF566; ZNF566; ZNF574 (directAnnotation). E2F3; E2F3; E2F4 (inferredBy_Orthology).
PSIP1	metacluster_7.13	ZFX (directAnnotation).
PSIP1	metacluster_3.11	SP1; SP1; SP2; SP3; SP3; SP4 (directAnnotation).
PSIP1	homer__GGGGGGGG_Maz	MAZ (directAnnotation).
PSIP1	transfac_pro__M01175	ZBTB7B (directAnnotation).
PSIP1	taipale_cyt_meth__ZNF460_NRMCGCCCCCCGN_eDBD_meth	ZNF460 (directAnnotation).
PSIP1	tfdimers__MD00151	CHURC1 (directAnnotation).
PSIP1	metacluster_3.7	SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP1; SP2; SP2; SP2; SP2; SP3; SP3; SP3; SP4; SP4; SP4; SP4; SP4; SP4; SP5 (directAnnotation).
PSIP1	metacluster_15.1	E2F4; E2F4; E2F4; E2F4; E2F7; ZFP69B (directAnnotation). E2F4 (inferredBy_Orthology).
PSIP1	transfac_pro__M01303	SP1 (directAnnotation).
PSIP1	metacluster_141.5	NR3C1; THAP1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY1; YY2; YY2; ZNF597 (directAnnotation). YY1; YY1; YY1; YY2; ZFP42 (inferredBy_Orthology).
PSIP1	swissregulon__hs__CHD1	CHD1 (directAnnotation).
PSIP1	transfac_pro__M02090	E2F4 (directAnnotation).
PSIP1	transfac_pro__M01714	KLF15 (directAnnotation).
PSIP1	jaspar__MA1122.1	TFDP1 (directAnnotation).
PSIP1	hocomoco__PROX1_HUMAN.H11MO.0.D	PROX1 (directAnnotation).
PSIP1	transfac_pro__M02089	E2F3 (directAnnotation).
PSIP1	metacluster_3.14	WT1; WT1 (directAnnotation).
PSIP1	metacluster_3.4	SP1; SP2; SP2; SP3 (directAnnotation).
PSIP1	hocomoco__EGR4_HUMAN.H11MO.0.D	EGR4 (directAnnotation).
PSIP1	metacluster_3.5	KLF14; KLF15; KLF15; KLF16 (directAnnotation).
PSIP1	cisbp__M07938	E2F1 (directAnnotation).
PSIP1	kznf__ZNF202_Imbeault2017_OM_MEME	ZNF202 (directAnnotation).
PSIP1	homer__GGCGGGAARN_E2F6	E2F6 (directAnnotation).
PSIP1	transfac_pro__M07436	WT1 (directAnnotation).
PSIP1	transfac_pro__M02281	SP1 (directAnnotation).
PSIP1	taipale_tf_pairs__GCM1_ELF1_GTGCGGGCGGAAGTN_CAP_repr	ELF1; GCM1 (directAnnotation).
PSIP1	kznf__ZNF730_Imbeault2017_RP_RCADE	ZNF730 (directAnnotation).
PSIP1	transfac_pro__M02898	SMAD3 (directAnnotation).
PSIP1	transfac_public__M00491	PATZ1 (directAnnotation).
PSIP1	transfac_pro__M07461	KLF1; KLF10; KLF11; KLF12; KLF13; KLF15; KLF16; KLF17; KLF2; KLF3; KLF4; KLF5; KLF6; KLF7; KLF8; KLF9 (directAnnotation).
PSIP1	jaspar__MA1708.1	ETV7 (directAnnotation).
PSIP1	taipale_tf_pairs__FOXO1_ETV4_RCCGGAWGTKKN_CAP	ETV4; FOXO1 (directAnnotation).
PSIP1	taipale_tf_pairs__ETV2_RFX5_NNNTTCCGSNNNNGCAACNN_CAP_repr	ETV2; RFX5 (directAnnotation).
PSIP1	taipale_tf_pairs__GCM1_ETV4_RTGCGGGCGGAAGTR_CAP	ETV4; GCM1 (directAnnotation).
PSIP1	taipale_tf_pairs__ELK1_FOXI1_WGTTKMCGGAWRTN_CAP	ELK1; FOXI1 (directAnnotation).
PSIP1	jaspar__MA0748.2	YY2 (directAnnotation).
PSIP1	taipale_cyt_meth__ZNF385D_NCGTCGCGACGN_eDBD_meth	ZNF385D (directAnnotation).
PSIP1	dbtfbs__GMEB1_K562_ENCSR928KOR_merged_N1	GMEB1 (directAnnotation).

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Acts as a transcription factor

This table shows that this differential gene acts as a transcription factor.

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Acts as a drug target

This table shows that this differential gene acts as a drug target.

1	"Sun X, Zhang Y, Li H, Zhou Y, Shi S, Chen Z, He X, Zhang H, Li F, Yin J, Mou M, Wang Y, Qiu Y, Zhu F. DRESIS: the first comprehensive landscape of drug resistance information. Nucleic Acids Res. 2023 Jan 6;51(D1):D1263-D1275. doi: 10.1093/nar/gkac812. PMID: 36243960; PMCID: PMC9825618."
2	"Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M. DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037. PMID: 29126136; PMCID: PMC5753335."